NIMH Chemical Synthesis and Drug Supply Program

WHAT IS AVAILABLE:

Synthesis of ligands for CNS receptors, radiolabeled compounds for autoradiography and neuroimaging, biochemical markers, drug analogs and metabolites, and reference standards.
GLP and GMP synthesis of promising compounds for toxicology and safety studies, especially compounds for PET neuroimaging.
Compounds currently available in stock are listed in the NIMH Repository , available on-line at the web site http://nimh-repository.rti.org.

WHO IS ELIGIBLE: Investigators involved in basic or clinical research relevant to mental health. To learn more about current research areas, please visit the NIMH Research Web Areas at http://www.nimh.gov/research/nimhwebs.cfm. NIMH Repository compounds are pro-vided free to qualified academic investigators.

HOW TO SUBMIT REQUESTS: Requests for repository compounds and for the synthesis of compounds, together with supporting information, should be submitted on the NIMH Order Form located at the repository web site http://nimh-repository.rti.org. Alternatively, requests may be mailed to Jamie Driscoll (NIMH) or Ken Rehder (RTI International) ( please see contact information).

Investigators interested in obtaining radiolabeled compounds but uncertain about what type of label or specific activity would work best for them may obtain help by contacting Jamie Driscoll (NIMH) or Anita Lewin (RTI International) (see contact information).

REQUESTS SHOULD INCLUDE:

A brief summary of the significance of the compound to the investigator’s research and an indication of the importance of the research to neuroscience.
A description of the protocols to be employed with the compounds, and detailed justification on the amounts required. For in vivo assay, please include information on projected dose levels, number of animals, etc., so that the calculations support the requested amount.
Current IACUC or IRB assurances, if appropriate.
Primary source of financial support for the proposed research.
For radiolabeled compounds, a copy of the institution’s current NRC license showing the authorized amount of the specific isotope and the license expiration date.
For synthesis requests, please include information on prior sources of the compound or related compounds, if available. Literature citations relevant to the synthesis of the target compound or related compounds are essential to the evaluation of the request. Please note that requests for GLP or GMP synthesis will require additional information and another level of review. Please contact Jamie Driscoll at NIMH.

PAYMENT: A payment may be required from nonacademic requestors. Terms are net 30 days from the date of invoice.