NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: C-807
Compound Name: Clozapine
Alternative Name: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine; 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Abbreviation: HF-1854, Leponex, Clozaril
PubChemID: 135398737
CAS: 5786-21-0
Molecular Formula: C18H19ClN4
Biological Activity: Selective dopamine D4 receptor antagonist, atypical antipsychotic used to treat schizophrenia
References: Raja, M., Current Drug Saf.,2011, 6, 164–184. Siskind, D.; McCartney, L.; Goldschlager, R.; Kisely, S. Br. J. Psych., 2016, 209, 385–392.
Last Updated 2021-02-17 02:44 PM
Structure of C-807
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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