NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: [3H]-(S)-(-)-N-0437
NIMH Code: N-804
Alternative Name: [3H]-(-)-2-(N-[2,3(n)3H]Propyl-N-(2-thiofuranyl)-2’-ethylamino)-5-hydroxy-1,2,3,4-tetrahydronaphthalene Hydrochloride
Abbreviation:
Indications: dopamine receptor agonist
Package Sizes:
References: J. Maj, M. Dziedzicka-Wasylewska, R. Rogoz, Z. Rogoz and G. Skuza, Antidepressant drugs given repeatedly change the binding of the dopamine D2 receptor agonist, [3H]N-0437, to dopamine D2 receptors in the rat brain, Eur. J. Pharmacol., 304, 49-54 (1996); J. V. der Weide, J. B. De Vries, P. G. Tepper and A. S. Horn, The effects of kainic acid and 6-hydroxydopamine lesions, metal ions and GTP on in vitro binding of the D-2 dopamine agonist, [3H]N-0437, to striatal membranes, Eur. J. Pharmacol., 143, 101-107 (1987); J. V. der Weide, J. B. De Vries, P. G. Tepper and A. S. Horn, In vitro binding of the very potent and selective D-2 dopamine agonist, [3H]N-0437, to calf caudate membranes, Eur. J. Pharmacol., 134, 211-219 (1987).
CAS: 92206-54-7
Molecular Formula: C19H24T2ClNOS
HBA: 3
HBD: 1
RotB: 6
PubChemID: 6917969
AlogP: 4.0569305
TPSA: 51.71
Activity:
Comments: Originally prepared in May 1999.
Last Updated 2008-11-11 02:54 PM
Structure of N-804
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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