NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: SR 144528
NIMH Code: S-801
Alternative Name: N-[(1S)-Endo-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)pyrazole-3-carboxamide
Indications: CB2 cannabinoid receptor antagonist
Package Sizes:
References: D. A. Scott, C. E. Wright and J. A. Angus, Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat, Pain, 109, 124-131 (2004); A. G. Nackley, A. Makriyannis and A. G. Hohmann, Selective activation of cannabinoid CB2 receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation, Neuroscience, 119, 747-757 (2003); G. Griffin, E. J. Wray, Q. Tao, S. D. McAllister, W. K. Rorrer, M. Aung, B. R. Martin and M. E. Abood, Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system, Eur. J. Pharmacol., 377, 117-125 (1999).
CAS: 192703-06-3
Molecular Formula: C29H34ClN3O
HBA: 3
HBD: 1
RotB: 5
PubChemID: 3081355
AlogP: 7.1267
TPSA: 46.92
Activity: CB2 cannabinoid receptor antagonist
Last Updated 2008-11-11 03:01 PM
Structure of S-801
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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