NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: P-908
Compound Name: 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine (C21) Dihydrochloride New!
Alternative Name: DREADD Compound 21 Dihydrochloride
Abbreviation: C21 2HCl
PubChemID: 11818276 (base)
CAS: 56296-18-5 (base)
Molecular Formula: C17H20Cl2N4
Biological Activity: DREADD ligand
References: 1. Thompson, K. J.; Khajehali, E.; Bradley, S. J.; Navarrete, J. S.; Huang, X. P.; Slocum, S.; Jin, J.; Liu, J.; Xiong, Y.; Olsen, R. H. J.; Diberto, J. F.; Boyt, K. M.; Pina, M. M.; Pati, D.; Molloy, C.; Bundgaard, C.; Sexton, P. M.; Kash, T. L.; Krashes, M. J.; Christopoulos, A.; Roth, B. L.; Tobin, A. B. ACS Pharmacol. Transl. Sci. 2018, 1, 61-72. 2. Jendryka, M.; Palchaudhuri, M.; Ursu, D.; van der Veen, B.; Liss, B.; Katzel, D.; Nissen, W.; Pekcec, A., Sci. Rep. 2019, 9, 4522.
Comments: Water soluble
Last Updated 2021-05-28 11:42 AM
Structure of P-908
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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