NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Structure of A-803
Compound Name: (RS)-1-Amino-5-phosphonoindan-1-carboxylic Acid
NIMH Code: A-803
Alternative Name:
Abbreviation: (RS)-APICA
Indications: Rigid MPPG analog; selective group II metabotropic glutamate receptor antagonist
Package Sizes:
References: E. Viard and H. N. Sapru, Cardiovascular responses to activation of metabotropic glutamate receptors in the nTS of the rat, Brain Res., 952, 308-321 (2002); D. Ma, H. Tian, H. Sun, A. P. Kozikowshi, S. Pshenichkin and J. T. Wroblewski, Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists, Bioorg. Med. Chem. Lett., 7, 1195-1198 (1997).
CAS:
Molecular Formula: C10H12NO5P
HBA: 6
HBD: 4
RotB: 2
PubChemID: 4694355
AlogP: -2.4794362
TPSA: 130.66
Activity:
Comments:
Last Updated 2008-11-10 03:12 PM