NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (RS)-1-Amino-5-phosphonoindan-1-carboxylic Acid
NIMH Code: A-803
Alternative Name:
Abbreviation: (RS)-APICA
Indications: Rigid MPPG analog; selective group II metabotropic glutamate receptor antagonist
Package Sizes:
References: E. Viard and H. N. Sapru, Cardiovascular responses to activation of metabotropic glutamate receptors in the nTS of the rat, Brain Res., 952, 308-321 (2002); D. Ma, H. Tian, H. Sun, A. P. Kozikowshi, S. Pshenichkin and J. T. Wroblewski, Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists, Bioorg. Med. Chem. Lett., 7, 1195-1198 (1997).
Molecular Formula: C10H12NO5P
HBA: 6
HBD: 4
RotB: 2
PubChemID: 4694355
AlogP: -2.4794362
TPSA: 130.66
Last Updated 2008-11-10 03:12 PM
Structure of A-803
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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