WHAT IS AVAILABLE:
- Custom synthesis of ligands for CNS receptors, radiolabeled compounds
and reference standards for autoradiography and neuroimaging, biochemical
markers, drug analogs and metabolites.
- Medicinal chemistry and optimization services to convert promising
compounds into suitable biological probes or to optimize small molecules
for in vivo applications.
- GMP synthesis of promising compounds for toxicology and safety
studies, especially compounds for PET neuroimaging.
- Compounds currently available are listed in the Compounds Catalog.
WHO IS ELIGIBLE:
Investigators involved in basic or clinical research relevant to mental
health. To learn more about current research areas, please visit the NIMH
Research Priorities page at
NIMH CSDSP compounds are provided free to qualified academic investigators.
HOW TO SUBMIT REQUESTS:
Requests for compounds and for the synthesis of compounds (including
radiolabeled compounds), together with supporting information, should be
submitted on the Order Form. Alternatively, questions or requests
may be emailed to Ken Rehder (RTI International) or Jamie Driscoll (NIMH)
REQUESTS SHOULD INCLUDE:
- A brief description of the intended use and importance of the compound
to the investigator's research, mental health, and neuroscience.
- A description of the protocols to be used with the compounds,
including detailed justification on the amounts required. For in vivo
studies, please include information on projected doses per animal, the
number of animals used, duration of the study, number of experiments,
etc., so that the calculations support the requested amount.
- Current IACUC or IRB assurances, if appropriate.
- Primary source of funding for the proposed research. For NIH supported
research, include the NIH grant number
- For radiolabeled compounds, a copy of the institution's current NRC
license showing the authorized amount of the specific isotope and the
license expiration date.
- For synthesis requests, please include information on prior sources of
the compound or related compounds, if available. Literature citations
relevant to the synthesis of the target compound or related compounds are
essential to the evaluation of the request. Please note that requests for
GMP synthesis will require additional information and another level of