NIMH Chemical Synthesis and Drug Supply Program


The NIMH is eager to be apprised of publications resulting from use of the Chemical Synthesis and Drug Supply Program (CSDSP)compounds it has supplied. In light of budgetary restrictions, The CSDSP frequently needs to justify its existence. If you find its service useful, please keep the CSDSP informed of your published results (see contacts).

In addition, please indicate in the Materials & Methods section of your publication that the compounds were obtained from the NIMH Chemical Synthesis and Drug Supply Program. If you are aware of key references about CSDSP compounds, please contact the CSDSP and the references will be added to the compound information page.

NIMH CSDSP referencing publications:

Ng, K., Pollock, M., Escobedo, A., Bachman, B., Miyazaki, N., Bartlett, E.L. and Sangha, S., Suppressing fear in the presence of a safety cue requires infralimbic cortical signaling to central amygdala, Neuropsychopharmacology, 49(2), pp.359-367 (2024).

Cheung, T.H., Ding, Y., Zhuang, X. and Kang, U.J., Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment, Proceedings of the National Academy of Sciences, 120(12), p.e2213093120 (2023).

Xie, X., Chen, R., Wang, X., Smith, L. and Wang, J., Activity-dependent labeling and manipulation of fentanyl-recruited striatal ensembles using ArcTRAP approach, STAR protocols, 4(3), p.102369 (2023).

Bertran-Gonzalez, J., Dinale, C. and Matamales, M., Restoring the youthful state of striatal plasticity in aged mice re-enables cognitive control of action, Current Biology, 33(10), pp.1997-2007 (2023).

Koster, K.P., Flores-Barrera, E., de la Villarmois, E.A., Caballero, A., Tseng, K.Y. and Yoshii, A., Loss of Depalmitoylation Disrupts Homeostatic Plasticity of AMPARs in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis, Journal of Neuroscience, 6 December 2023, 43 (49) 8317-8335.

Lawson, K. A., Ruiz, C. M., & Mahler, S. V., A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition, Psychopharmacology, 240(10), 2101-2110 (2023).

Cope, E.C., Wang, S.H., Waters, R.C., Gore, I.R., Vasquez, B., Laham, B.J. and Gould, E., Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice, Nature communications, 14(1), p.1750 (2023).

Gangal, H., Xie, X., Huang, Z., Cheng, Y., Wang, X., Lu, J., Zhuang, X., Essoh, A., Huang, Y., Chen, R. and Smith, L.N., Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons, Nature Communications, 14(1), p.3886 (2023).

Abe, C., Katayama, C., Bazek, M., Nakamura, Y., Ohbayashi, K., Horii, K., Fujimoto, C., Tanida, M., Iwasaki, Y., Inoue, T. and Nin, F., Repeated activation of C1 neurons in medulla oblongata decreases anti-inflammatory effect via the hypofunction of the adrenal gland adrenergic response, Brain, Behavior, and Immunity, 111, pp.138-150 (2023).

Zanos, P., Brown, K.A., Georgiou, P., Yuan, P., Zarate, C.A., Thompson, S.M. and Gould, T.D., NMDA receptor activation-dependent antidepressant-relevant behavioral and synaptic actions of ketamine, Journal of Neuroscience, 43(6), pp.1038-1050 (2023).

Abe, C., Katayama, C., Bazek, M., Ohbayashi, K., Horii, K., Tanida, M., Nin, F. and Iwasaki, Y., Hepatic glycogenolysis and hypometabolism induced by chemogenetic stimulation of C1 neurons, The Journal of Physiology, 601(12), pp.2293-2306 (2023).

Fratta, S., Biniecka, P., Moreno-Vargas, A.J., Carmona, A.T., Nahimana, A., Duchosal, M.A., Piacente, F., Bruzzone, S., Caffa, I., Nencioni, A. and Robina, I., Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer, European Journal of Medicinal Chemistry, 250, p.115170 (2023).

Lewis, V., Bonniwell, E.M., Lanham, J.K., Ghaffari, A., Sheshbaradaran, H., Cao, A.B., Calkins, M.M., Bautista-Carro, M.A., Arsenault, E., Telfer, A. and Taghavi-Abkuh, F.F., A non-hallucinogenic LSD analog with therapeutic potential for mood disorders, Cell reports, 42(3) (2023).

Wang, W., Xie, X., Zhuang, X., Huang, Y., Tan, T., Gangal, H., Huang, Z., Purvines, W., Wang, X., Stefanov, A. and Chen, R., Striatal ?-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect, Cell reports 42(2) (2023).


Verpeut, J.L., Bergeler, S., Kislin, M., William Townes, F., Klibaite, U., Dhanerawala, Z.M., Hoag, A., Janarthanan, S., Jung, C., Lee, J. and Pisano, T.J., Cerebellar contributions to a brainwide network for flexible behavior in mice, Communications Biology, 6(1), p.605 (2023).

Li, Y.D., Luo, Y.J., Xie, L., Tart, D.S., Sheehy, R.N., Zhang, L., Coleman, L.G., Chen, X. and Song, J., Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease, Cell stem cell, 30(4), pp.415-432 (2023).

Li, Y.D., Luo, Y.J., Chen, Z.K., Quintanilla, L., Cherasse, Y., Zhang, L., Lazarus, M., Huang, Z.L. and Song, J., Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior, Nature neuroscience, 25(5), pp.630-645 (2022).

Bolton, J.L., Short, A.K., Othy, S., Kooiker, C.L., Shao, M., Gunn, B.G., Beck, J., Bai, X., Law, S.M., Savage, J.C. and Lambert, J.J., Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses, Cell reports, 38, 13 (2022).

Sciolino, N.R., Hsiang, M., Mazzone, C.M., Wilson, L.R., Plummer, N.W., Amin, J., Smith, K.G., McGee, C.A., Fry, S.A., Yang, C.X. and Powell, J.M., Natural locus coeruleus dynamics during feeding, Science advances, 8, 33 (2022): p.eabn9134.

Tickerhoof, M., She Loves Me, He Loves Me Not: Regulation of Social Conflict-Induced Changes in Social Behavior and Attachment by the Amygdala and Extended Amygdala, University of Kansas ProQuest Dissert. Pub., 2022.29208557.

McGovern, D.J., Ly, A., Ecton, K.L., Huynh, D.T., Prévost, E.D., Gonzalez, S.C., McNulty, C.J., Rau, A.R., Hentges, S.T., Daigle, T.L. and Tasic, B., Ventral tegmental area glutamate neurons mediate nonassociative consequences of stress, Molecular Psychiatry, pp.1-12 (2022).

Nawreen, N., Prefrontal Cortex in Stress Related Disorders: Characterizing the Role of Inhibitory Gabaergic Parvalbumin Interneurons in Stress Related Illnesses, University of Cincinnati ProQuest Dissert. Pub., 2022.29730341

Monday, H.R., Kharod, S.C., Yoon, Y.J., Singer, R.H. and Castillo, P.E., Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals, Neuron, 110(16), pp.2588-2606 (2022).

Delevich, K., Hoshal, B., Zhang, Y., Vedula, S., Collins, A.G. and Wilbrecht, L., Activation But Not Inhibition of the Indirect Pathway Disrupts Choice Suppression in a Freely Moving, Multiple Choice Foraging Task, Cell Reports, 40, 111129 (2022).


Ogbeide-Latario, O.E., Ferrari, L.L., Gompf, H.S., Anaclet, C., Two novel mouse models of slow-wave-sleep enhancement in aging and Alzheimer’s disease, Sleep Advances, 3(1), p.zpac022 (2022).

L. L. Ferrari, O. E. Ogbeide-Latario, H. S. Gompf, C. Anaclet, Validation of DREADD agonists and administration route in a murine model of sleep enhancement, Journal of Neuroscience Methods, 380, 109679 (2022).

Ghanem, M.S., Caffa, I., Del Rio, A., Franco, J., Parenti, M.D., Monacelli, F., Cea, M., Khalifa, A., Nahimana, A., Duchosal, M.A. and Ravera, S., Identification of NAPRT inhibitors with anti-cancer properties by in silico drug discovery, Pharmaceuticals, 15(7), p.848 (2022).

Franco, J., Piacente, F., Walter, M., Fratta, S., Ghanem, M., Benzi, A., Caffa, I., Kurkin, A.V., Altieri, A., Herr, P. and Martínez-Bailén, M., Structure-based identification and biological characterization of new NAPRT inhibitors, Pharmaceuticals, 15(7), p.855 (2022).

Piantadosi, S.C., Manning, E.E., Chamberlain, B.L., Hyde, J., LaPalombara, Z., Bannon, N.M., Pierson, J.L., Namboodiri, V.M. and Ahmari, S.E., Hyperactivity of indirect pathway-projecting spiny projection neurons drives compulsive behavior, bioRxiv, pp.2022-02 (2022).

W.T. Doucette, E.B. Smedley, M. Ruiz-Jaquez, J.Y. Khokhar, K.S. Smith, Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet, Brain Research, 1784, p.147886 (2022).

K.A. Amaya, K.S. Smith, Spatially restricted inhibition of cholinergic interneurons in the dorsolateral striatum encourages behavioral exploration, European Journal of Neuroscience, 53(8), pp.2567-2579 (2021).

W.S. Kim, J. Liu, Q. Li, S. Hong, K. Qi, R. Cherukuri, B.-J. Yoon, J. Moscarello, Y. Choe, S. Maren, S. Il Park, AI-driven high-throughput automation of behavioral analysis and dual-channel wireless optogenetics for multiplexing brain dynamics, bioRxiv, 09.23.461279 (2021);

R.L. Ressler, T.D. Goode, S. Kim, K.R. Ramanathan, S. Maren, Covert capture and attenuation of a hippocampus-dependent fear memory, Nat Neurosci. 24(5):677-684 (2021).

Saucisse N, Mazier W, Simon V, Binder E, Catania C, Bellocchio L, Romanov RA, Léon S, Matias I, Zizzari P, Quarta C., Functional heterogeneity of POMC neurons relies on mTORC1 signaling, Cell Reports, 2021 Oct 12;37(2):109800.

Manning EE, Geramita MA, Piantadosi SC, Pierson JL, Ahmari SE., Distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine, Biological Psychiatry, 2021 Nov 27.

Wu T, Zhu J, Strickland A, Ko KW, Sasaki Y, Dingwall CB, Yamada Y, Figley MD, Mao X, Neiner A, Bloom AJ., Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss, Cell reports, 2021 Oct 19;37(3):109872.

Manning EE, Geramita MA, Piantadosi SC, Ahmari SE., Independent and distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine, bioRxiv, 2021 Jan 1.

Yates JR, Horchar MJ, Ellis AL, Kappesser JL, Mbambu P, Sutphin TG, Dehner DS, Igwe HO, Wright MR., Differential effects of glutamate N-methyl-d-aspartate receptor antagonists on risky choice as assessed in the risky decision task, Psychopharmacology, 2021 Jan;238(1):133-48.

Wang Y, Guo R, Chen B, Rahman T, Cai L, Li Y, Dong Y, Tseng GC, Fang J, Seney ML, Huang YH., Cocaine-induced neural adaptations in the lateral hypothalamic melanin-concentrating hormone neurons and the role in regulating rapid eye movement sleep after withdrawal, Molecular psychiatry, 2021 Jul;26(7):3152-68.

Hupalo S, Spencer RC, Berridge CW., Prefrontal corticotropin-releasing factor neurons impair sustained attention via distal transmitter release, European Journal of Neuroscience, 2021 Jul 1;54(1):4182-96.

Satanove DJ, Rahman S, Chan TM, Ren S, Clarke P., Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects, Psychopharmacology, 2021 Feb;238(2):475-86.

Laham BJ, Diethorn EJ, Gould E., Newborn mice form lasting CA2-dependent memories of their mothers, Cell reports, 2021 Jan 26;34(4):108668.

Delevich K, Hall CD, Wilbrecht L., Prepubertal ovariectomy alters dorsomedial striatum indirect pathway neuron excitability and explore/exploit balance in female mice, bioRxiv. 2021 Jan 1.

Duin AA, Aman L, Schmidt B, Redish AD., Certainty and uncertainty of the future changes planning and sunk costs, Behavioral Neuroscience, 2021 Jun 24.

Koczor CA, Saville KM, Andrews JF, Clark J, Fang Q, Li J, Al-Rahahleh RQ, Ibrahim M, McClellan S, Makarov MV, Migaud ME., Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis, Cell reports, 2021 Nov 2;37(5):109917.

J.P. Bauer, S.L. Rader, M.E. Joffe, W. Kwon, J. Quay, L. Seanez, C. Zhou, P.J. Conn, A.S. Lewis, Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus, bioRxiv, pp.2020-12 (2021).

Lituma, P.J., Kwon, H.B., Alviña, K., Luján, R. and Castillo, P.E., Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses, Elife, 10, p.e66612 (2021).

Schmidt, B. and Redish, A.D., Disrupting the medial prefrontal cortex with designer receptors exclusively activated by designer drug alters hippocampal sharp?wave ripples and their associated cognitive processes, Hippocampus, 31(10), pp.1051-1067 (2021).

Emmons, R., Sadok, T., Rovero, N.G., Belnap, M.A., Henderson, H.J., Quan, A.J., Del Toro, N.J. and Halladay, L.R., Chemogenetic manipulation of the bed nucleus of the stria terminalis counteracts social behavioral deficits induced by early life stress in C57BL/6J mice, Journal of Neuroscience Research, 99(1), pp.90-109 (2021).

Figley, M.D., Gu, W., Nanson, J.D., Shi, Y., Sasaki, Y., Cunnea, K., Malde, A.K., Jia, X., Luo, Z., Saikot, F.K. and Mosaiab, T., SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration, Neuron, 109(7), pp.1118-1136 (2021).

Lituma, P.J., Mechanisms of Information Transfer and Storage in the Mammalian Hippocampus. Albert Einstein College of Med. ProQuest Dissert. Pub. 2021.28720978.

Ogbeide-Latario, O., The Role of Slow-Wave-Sleep in Hippocampus-Dependent Memory in Aging and Alzheimer's Disease (Doctoral dissertation), eScholarship@UMassChan (2021)

Francesconi, W., Berton, F., Olivera-Pasilio, V. and Dabrowska, J., Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala, Neuropharmacology, 192, p.108601 (2021).

Fournier, D.I., The Contributions of the Retrosplenial Cortex to Learning and Behavior, Dartmouth College ProQuest Dissert. Pub., 2021.28153748.

Wang, M., Gallo, N.B., Tai, Y., Li, B. and Van Aelst, L., Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex, Neuron, 109(10), pp.1636-1656 (2021).

Shaik, T.B., Malik, M.S., Routhu, S.R., Seddigi, Z.S., Althagafi, I.I. and Kamal, A., Evaluation of anticancer and anti-mitotic properties of quinazoline and quinazolino-benzothiadiazine derivatives, Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 20(5), pp.599-611 (2020).

Trujillo-Pisanty, I., Conover, K., Solis, P., Palacios, D. and Shizgal, P., Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward, PLoS One, 15(6), p.e0226722 (2020).

Levinstein, M.R., Diversity of Lateral Habenula Neuron Roles in Negative Valence Events, University of Washington ProQuest Dissert. Pub., 2020.28262240

Yoo, J.I., Daugherty, P.S. and O’Malley, M.A., Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR, Nature communications, 11(1), p.690 (2020).

Wang, Y., Bouabid, S., Darvas, M. and Zhou, F.M., The antiparkinson drug ropinirole inhibits movement in a Parkinson's disease mouse model with residual dopamine neurons, Experimental Neurology, 333, p.113427 (2020).

Li, Y., Bao, H., Luo, Y., Yoan, C., Sullivan, H.A., Quintanilla, L., Wickersham, I., Lazarus, M., Shih, Y.Y.I. and Song, J., Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release, elife, 9, p.e53129 (2020).

Asrican, B., Wooten, J., Li, Y.D., Quintanilla, L., Zhang, F., Wander, C., Bao, H., Yeh, C.Y., Luo, Y.J., Olsen, R. and Lim, S.A., Neuropeptides modulate local astrocytes to regulate adult hippocampal neural stem cells, Neuron, 108(2), pp.349-366 (2020).

Li, Y., Bao, H., Luo, Y., Yoan, C., Sullivan, H.A., Quintanilla, L., Wickersham, I., Lazarus, M., Shih, Y.Y.I. and Song, J., Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release, elife, 9, p.e53129 (2020).

Pandey, S. and Barson, J.R., Heightened exploratory behavior following chronic excessive ethanol drinking: Mediation by neurotensin receptor type 2 in the anterior paraventricular thalamus, Alcoholism: Clinical and Experimental Research, 44(9), pp.1747-1759 (2020).

Tran, F.H., Spears, S.L., Ahn, K.J., Eisch, A.J. and Yun, S., Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or Compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREADD-expressing mice? Neuroscience letters, 739, p.135432 (2020).

Jagtap, P.K.A., Kubelka, T., Soni, K., Will, C.L., Garg, D., Sippel, C., Kapp, T.G., Potukuchi, H.K., Schorpp, K., Hadian, K. and Kessler, H., Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly, Nature Communications, 11(1), p.5621 (2020).

Plaza-Briceño, W., Estay, S.F., de la Fuente-Ortega, E., Gutiérrez, C., Sánchez, G., Hidalgo, C., Chávez, A.E. and Haeger, P.A., N-Methyl-d-Aspartate receptor modulation by nicotinamide adenine dinucleotide phosphate oxidase type 2 drives synaptic plasticity and spatial memory impairments in rats exposed pre-and postnatally to ethanol, Antioxidants & Redox Signaling, 32(9), pp.602-617 (2020).

Monday, H.R., Bourdenx, M., Jordan, B.A. and Castillo, P.E., CB1-receptor-mediated inhibitory LTD triggers presynaptic remodeling via protein synthesis and ubiquitination, Elife, 9, p.e54812 (2020).

Fitzpatrick, J.M., Minogue, E., Curham, L., Tyrrell, H., Gavigan, P., Hind, W. and Downer, E.J., MyD88-dependent and-independent signalling via TLR3 and TLR4 are differentially modulated by ?9-tetrahydrocannabinol and cannabidiol in human macrophages, Journal of neuroimmunology, 343, p.577217 (2020).

Halberstadt, A.L., Chatha, M., Klein, A.K., Wallach, J. and Brandt, S.D., Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species, Neuropharmacology, 167, p.107933 (2020).

Tétreault, P., Besserer-Offroy, É., Brouillette, R.L., René, A., Murza, A., Fanelli, R., Kirby, K., Parent, A.J., Dubuc, I., Beaudet, N. and Côté, J., Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog, European Journal of Pharmacology, 882, p.173174 (2020).

Trana, F.H., Stella, L.S., Ahna, K.J., Eischa, A.J. and Yuna, S., Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREAD expressing mice? bioRxiv preprint doi:

Dubois, C.J., Fawcett-Patel, J., Katzman, P.A. and Liu, S.J., Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation, Nature Communications, 11(1), p.6407 (2020).

L.A. Bradfield, B.K. Leung, S. Boldt, S. Liang, B.W. Balleine, Goal-directed actions transiently depend on dorsal hippocampus, Nature Neuroscience, 23(10), pp.1194-1197 (2020).

S. Gasparini, J.M. Resch, A.M. Gore, L. Peltekian, J.C. Geerling, Pre-locus coeruleus neurons in rat and mouse, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Dec 9. doi: 10.1152/ajpregu.00261.2020.

S. Liu, M. Ye, G.M. Pao, S.M. Song, J. Jhang, S. Han, Identification of a novel breathing circuit that controls pain and anxiety, BioRxiv. 2020 Jan 1.

W. Francesconi, F. Berton, V. Olivera-Pasilio, J. Dabrowska, Oxytocin selectively excites interneurons and inhibits output neurons of the bed nucleus of the stria terminalis (BNST), bioRxiv. (2020).

K.R. Coffey, R.G. Marx, E.K. Vo, S.G. Nair, J. F. Neumaier, Chemogenetic inhibition of lateral habenula projections to the dorsal raphe nucleus reduces passive coping and perseverative reward seeking in rats, Neuropsychopharmacology, 45(7), 1115–1124 (2020),

J.M. Moscarello, Prefrontal cortex projections to the nucleus reuniens suppress freezing following two-way signaled avoidance training, Learning & Memory, 27(3), pp.119-123 (2020).

L.Y. Brown, G.M. Alexander, J. Cushman, S.M. Dudek, Hippocampal CA2 organizes CA1 slow and fast ? oscillations during novel social and object interaction, Eneuro, 2020, 7(2).

C. Abe, Y. Yamaoka, Y. Maejima, T. Mikami, S. Yokota, A. Yamanaka, H. Morita, VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice, Communications Biology, 3, 227 (2020).

N. Nawreen, R. Morano, P. Mahbod, E.M. Cotella, K. Dalal, M. Fitzgerald, S. Martelle, B.A. Packard, R.D. Moloney, J.P. Herman, Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABA-ergic Parvalbumin-positive Interneurons Attenuates Chronic Stress Adaptions in Male Mice, eNeuro, 7(5), ENEURO.0423-19.2020.

T.F. Giustino, K.R. Ramanathan, M.S. Totty, O.W. Miles, S. Maren, Locus coeruleus norepinephrine drives stress-induced increases in basolateral amygdala firing and impairs extinction learning, Journal of Neuroscience, 40(4), 907-916 (2020).

K.A. Amaya, J.J. Stott, K.S. Smith, Sign-tracking behavior is sensitive to outcome devaluation in a devaluation context-dependent manner: implications for analyzing habitual behavior, Learning & Memory, 27(4), 136-149 (2020).

E.B. Smedley, A. DiLeo, K.S. Smith, Circuit directionality for motivation: lateral accumbens-pallidum, but not pallidum-accumbens, connections regulate motivational attraction to reward cues, Neurobiology of Learning and Memory, 162, pp.23-35(2019).

T.F. Giustino, P.J. Fitzgerald, R.L. Ressler, S. Maren, Locus coeruleus toggles reciprocal prefrontal firing to reinstate fear, Proceedings of the National Academy of Sciences, 116(17), 8570-8575 (2019).

A.F. Scheyer, M. Borsoi, J. Wager-Miller, A-L. Pelissier-Alicot, M.N. Murphy, K. Mackie, O.J.J. Manzoni, Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors, Biological Psychiatry, 2019-09, DOI: 10.1016/j.biopsych.2019.08.023.

B. Chamberlain, Investigating the role of striatal spiny projection neurons in compulsive behaviors, Undergraduate Thesis, University of Pittsburgh (2019).

S. Crowel, An Examination of Affective Blunting in Rodents, All NMU Master's Theses, 598 (2019).

B. Schmidt, A.A. Duin, A.D. Redish, Disrupting the medial prefrontal cortex alters hippocampal sequences during deliberative decision making, Journal of Neurophysiology, 121(6), 1981-2000 (2019).

N.R. Sciolino, C.M. Mazzone, N.W. Plummer, I. Evsyukova, J. Amin, K.G. Smith, C.A. McGee, S.A. Fry, C.X. Yang, J.M. Powell, M.R. Bruchas, A role for the locus coeruleus in the modulation of feeding, bioRxiv, 12.18.881599 (2019).

E.T.N.M.A. Erickson, L.L. Ferrari, H.S. Gompf, C. Anaclet, Differential role of pontomedullary glutamatergic neuronal populations in sleep-wake control, Frontiers in Neuroscience,. 13, 755 (2019).

E.E. Manning, A.Y. Wang, L.M. Saikali, A. Winner, S.E. Ahmari, Disruption of prepulse inhibition is associated with severity of compulsive behavior and nucleus accumbens dopamine system changes in Sapap3 knockout mice, bioRxiv, 694935 (2019).

P.D. Skelton, J. Poquerusse, J.R. Salinaro, M. Li, B.W. Luikart, Activity-dependent dendritic elaboration requires Pten, Neurobiology of Disease, 104703 (2019).

A.T. Slominski, T.K. Kim, K. Kleszczynski, I. Semak, Z. Janjetovic, T. Sweatman, C. Skobowiat, J.D. Steketee, Z. Lin, A. Postlethwaite, W. Li, Characterization of Serotonin and N-acetylserotonin Systems in the Human Epidermis and Skin Cells, Journal of Pineal Research, 2019.

K. Delevich, B. Hoshal, A.G. Collins, L. Wilbrecht, Choice suppression through opponent but not independent function of the striatal indirect pathway, bioRxiv, 675850 (2019).

M.B. Pomrenze, S.M. Giovanetti, R. Maiya, A.G. Gordon, L.J. Kreeger, R.O. Messing, Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning, Cell Reports, 29(1), 13-21 (2019).

A.L. Halberstadt, J.V. van der Zee, M. Chatha, M.A. Geyer, S.B. Powell, Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen, Psychopharmacology, 236(2): 821-830 (2019).

A.M. Van Dyke, T.C. Francis, H. Chen, A.M. Bailey, S.M. Thompson, Chronic fluoxetine treatment in vivo enhances excitatory synaptic transmission in the hippocampus, Neuropharmacology, 150, 38-45 (2019).

J.M. Kott, S.M. Mooney-Leber, S. Brummelte, Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression, Behavioural Brain Research, 366, 1-12 (2019).

S. Schiavi, A. Manduca, M. Segatto, P. Campolongo, V. Pallottini, L.J.M.J. Vanderschuren, V. Trezza, Unidirectional opioid-cannabinoid cross-tolerance in the modulation of social play behavior in rats, Psychopharmacology, doi: 10.1007/s00213-019-05226-y (2019).

E.A. Choi, P. Jean-Richard-dit-Bressel, C.W.G. Clifford, G.P. McNally, Paraventricular thalamus controls behavior during motivational conflict, Journal of Neuroscience, doi: 10.1523/JNEUROSCI.2480-18.2019 (2019).

M.B. Pomrenze, J. Tovar-Diaz, A. Blasio, R. Maiya, S.M. Giovanetti, K. Lei, H. Morikawa, F.W. Hopf, and R.O. Messing, A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety, J. Neuroscience, 6 February 2019, 39 (6) 1030-1043; DOI: 10.1523/JNEUROSCI.2143-18.2018 (2019).

G. de Guglielmo, M. Kallupi, M.B. Pomrenze, E. Crawford, S. Simpson, P. Schweitzer, G.F. Koob, R.O. Messing, O. George, Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 18 Mar 2019, 10(1):1238. DOI: 10.1038/s41467-019-09183-0 (2019).

B. Halbout, A.T. Marshall, A. Azimi, M. Liljeholm, S.V. Mahler, K.M. Wassum, S.B., Ostlund, Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats, Elife, 8, p.e43551 (2019).

G.M. Alexander, N.V. Riddick, K.E. McCann, D. Lustberg, S.S. Moy, S.M. Dudek, Modulation of CA2 neuronal activity increases behavioral responses to fear conditioning in female mice, Neurobiology of Learning and Memory, 163, p.107044 (2019).

D. Martinon, P. Lis, A.N. Roman, P. Tornesi, S.V. Applebey, G. Buechner, V. Olivera, J. Dabrowska, Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear, Translational Psychiatry, 9(1), pp.1-13 (2019).

D.I. Fournier, T.P. Todd, D.J. Bucci, Permanent damage or temporary silencing of retrosplenial cortex impairs the expression of a negative patterning discrimination, Neurobiology of Learning and Memory, 163, p.107033 (2019).

Haam, J., Zhou, J., Cui, G. and Yakel, J.L., Septal cholinergic neurons gate hippocampal output to entorhinal cortex via oriens lacunosum moleculare interneurons, Proceedings of the National Academy of Sciences, 115(8), pp.E1886-E1895 (2018).

C.A. Bouchet, M.A. Miner, E.C. Loetz, A.J. Rosberg, H.S. Hake, C.E. Farmer, M. Ostrovskyy, N. Gray, B.N. Greenwood, Activation of nigrostriatal dopamine neurons during fear extinction prevents the renewal of fear, Neuropsychopharmacology, 43(3), pp.665-672 (2018).

J. Taura, E.G. Nolen, G. Cabré, J. Hernando, L. Squarcialupi, M. López-Cano, K.A. Jacobson, V. Fernández-Dueñas, F. Ciruela, Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist, Journal of Controlled Release, 283, 135-142 (2018).

C. Anacker, V.M. Luna, G.S. Stevens, A. Millette, R. Shores, J.C. Jimenez, B. Chen, R. Hen, Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus, Nature, 559(7712), pp.98-102 (2018).

G. Hart, L.A. Bradfield, S.Y. Fok, B. Chieng, B.W. Balleine, The bilateral prefronto-striatal pathway is necessary for learning new goal-directed actions, Current Biology, 28(14), pp.2218-2229 (2018).

G.M. Alexander, L.Y. Brown, S. Farris, D. Lustberg, C. Pantazis, B. Gloss, N.W. Plummer, P. Jensen, S.M. Dudek, CA2 neuronal activity controls hippocampal low gamma and ripple oscillations, Elife, 7, p.e38052 (2018).

D. Neuhofer, O. Lassalle, O.J. Manzoni, Muscarinic M1 receptor modulation of synaptic plasticity in nucleus accumbens of wild-type and fragile X mice, ACS chemical neuroscience, 9(9), pp.2233-2240 (2018).

E.M. McGlinchey & G. Aston-Jones, Dorsal hippocampus drives context-induced cocaine seeking via inputs to lateral septum, Neuropsychopharmacology, 43, 987–1000 (2018).

L. Boekhoudt, E.C. Wijbrans, J.H.K. Man, M.C.M. Luijendijk, J.W. de Jong, G. van der Plasse, L.J.M.J. Vanderschuren, R.A.H. Adan, Enhancing excitability of dopamine neurons promotes motivational behaviour through increased action initiation, Eur. Neuropsychopharm. 28, 1, 171-184 (2018).

J.P.H. Verharen, J.W. de Jong, T.J.M. Roelofs, C.F.M. Huffels, R. van Zessen, M.C.M. Luijendijk, R. Hamelink, I. Willuhn, H.E.M. den Ouden, G. van der Plasse, R.A.H. Adan, L.J.M.J. Vanderschuren, A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states, Nature Communications, 9, 731 (2018).

R. Marek, J. Jin, T.D. Goode, T.F. Giustino, Q. Wang, G.M. Acca, R. Holehonnur, J.E. Ploski, P.J. Fitzgerald, T. Lynagh, J.W. Lynch, S. Maren, P. Sah, Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear, Nature Neuroscience, 21, 384–392 (2018).

E.F. Gallo, J. Meszaros, J.D. Sherman, M.O. Chohan, E. Teboul, C.S. Choi, H. Moore, J.A. Javitch, C. Kellendonk, Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum, Nature Communications, Mar 14;9(1):1086 (2018), doi: 10.1038/s41467-018-03272-2.

Y. Cheng, The role of dopamine D1 and D2 receptor-expressing striatal neurons in the corticostriatal circuitry of alcohol use disorder, Doctoral dissertation, Texas A & M University (2018).

K.R. Ramanathan, J. Jin, T.F. Giustino, M.R. Payne, S. Maren, Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction, Nature communications, 9, 4527 (2018).

T.A. LeGates, M.D. Kvarta, J.R. Tooley, T.C. Francis, M.K. Lobo, M.C. Creed, S.M. Thompson, Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses, Nature, 564, 258 (2018).

J. Zhang, C. Chen, Alleviation of neuropathology by inhibition of monoacylglycerol lipase in APP transgenic mice lacking CB2 receptors, Molecular Neurobiology, 55:4802-4810 (2018).

*P.M. Grace, X. Wang, K.A. Strand, M.V. Baratta, Y. Zhang, E.L. Galer, H. Yin, S.F. Maier, L.R. Watkins, DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats. Experimental Neurology, 304, 125–131, doi:10.1016/j.expneurol.2018.03.005 (2018).

*S.D. Dolzani, M.V. Baratta, J.M. Moss, N.L. Leslie, S.G. Tilden, A.T. Sørensen, L.R. Watkins, Y. Lin, S.F. Maier, Inhibition of a descending prefrontal circuit prevents ketamine-induced stress resilience in females, eNeuro, 5(1), ENEURO.0025-18.2018, doi:10.1523/ENEURO.0025-18.2018

D. Avesar, E.K. Stephens, A.T. Gulledge, Serotonergic regulation of corticoamygdalar neurons in the mouse prelimbic cortex, Frontiers in Neural Circuits, 12:63 (2018), doi: 10.3389/fncir.2018.00063.

E.K. Stephens, A.L. Baker, A.T. Gulledge, Mechanisms underlying serotonergic excitation of callosal projection neurons in the mouse medial prefrontal cortex, Frontiers in Neural Circuits, 12:2, doi:10.3389/fncir.2018.00002 (2018).

A. Bara, A. Manduca, A. Bernabeu, M. Borsoi, M. Serviado, O. Lassalle, M. Murphy, J. Wager-Miller, K. Mackie, A-L. Pelissier-Alicot, V. Trezza, O.J. Manzoni Sex-dependent effects of in utero cannabinoid exposure on cortical function, eLife, 2018-09-11, DOI: 10.7554/eLife.36234.

S.E. Chang, T.P. Todd, K.S. Smith, Paradoxical accentuation of motivation following accumbens-pallidum disconnection, Neurobiology of learning and memory, 149, pp.39-45 (2018).

C. Anaclet, K. Griffith, P.M. Fuller, Activation of the GABAergic Parafacial Zone Maintains Sleep and Counteracts the Wake-Promoting Action of the Psychostimulants Armodafinil and Caffeine, Neuropsychopharmacology, Jan;43(2):415-425 (2018).

C. Anaclet, R. De Luca, A. Venner, O. Malyshevskaya, M. Lazarus, E. Arrigoni, P.M. Fuller, Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control, J. Neurosci. May 30;38(22):5168-5181 (2018).

D.F. Manvich, K.A. Webster, S.L. Foster, M.S. Farrell, J.C Ritchie, J.H. Porter, D. Weinshenker, The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice, Scientific Reports, 8(1), 1-10 (2018).

M. Borsoi, A. Manduca, A. Bara, O. Lassalle, A.L. Pelissier-Alicot, O.J. Manzoni, Sex differences in the behavioral and synaptic consequences of a single exposure to cannabinoid at puberty and adulthood, bioRxiv, p.415067 (2018).

Badura, A., Verpeut, J.L., Metzger, J.W., Pereira, T.D., Pisano, T.J., Deverett, B., Bakshinskaya, D.E. and Wang, S.S., Normal cognitive and social development require posterior cerebellar activity, Elife, 7, p.e36401 (2018).

J.L. Carlin, S. Jain, R. Duroux, R.R. Suresh, C. Xiao, J.A. Auchampach, K.A. Jacobson, O. Gavrilova, M.L. Reitman, Activation of adenosine A2A or A2B receptors causes hypothermia in mice, Neuropharmacology, (2018).

J.M. Kott, S.M. Mooney-Leber, J. Li, S. Brummelte, Elevated stress hormone levels and antidepressant treatment starting before pregnancy affect maternal care and litter characteristics in an animal model of depression, Behavioural. Brain Res., 348, 101-114 (2018).

C. Dumon, D. Diabira, I. Chudotvorova, F. Bader, G.S. Sahin, J. Zhang, C. Porcher, G. Wayman, I. Medina, J-L. Gaiarsa, The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice, eLife , 7, e36726 (2018).

P. Ratano, C. Petrella, F. Forti, P.P. Passeri, M. Morena, M. Palmery, V. Trezza, C. Severini, P. Campolongo, Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation, Neuropharmacology, 138, 210-218 (2018).

M. Wickert, K.L. Hildick, G.L. Baillie, R. Jelinek, A. Aparisi Rey, K. Monory, M. Schneider, R. Ross, J. Henley, B. Lutz, The F238L point mutation in the cannabinoid type-1 receptor enhances basal endocytosis via lipid rafts, Frontiers in Molecular Neuroscience, 11, 230 (2018).

J.I. Yoo, M.A. O’Malley, Tuning vector stability and integration frequency elevates functional GPCR production and homogeneity in saccharomyces cerevisiae, ACS Synth. Biol., 7 (7), 1763–1772 (2018).

N.A. Upright, S.W. Brookshire, W. Schnebelen, C.G. Damatac, P.R. Hof, P.G.F. Browning, P.L. Croxson, P.H. Rudebeck, M.G. Baxter, Behavioral effect of chemogenetic inhibition is directly related to receptor transduction levels in rhesus monkeys, J. Neuroscience, 6 August 2018, 1422-18 (2018).

E.T. Baltz, E.A. Yalcinbas, R. Renteria, C.M. Gremel, Orbital frontal cortex updates state-induced value change for decision-making, eLife, 7, e35988 (2018).

C-Y. Yeh, B. Asrican, J. Moss, L.J. Quintanilla, T. He, X. Mao, F. Cassé, E. Gebara, H. Bao , W. Lu, N. Toni, Mossy cells control adult neural stem cell quiescence and maintenance through a dynamic balance between direct and indirect pathways, Neuron (2018).

G.A. Kane, Behavioral and neural mechanisms of patch foraging, ProQuest Dissertations Publishing, Princeton University 10814299 (2018).

K.N. Swonger, A.S. Robinson, Using fluorescence anisotropy for ligand binding kinetics of membrane proteins, Current Protocols in Protein Science, 93(1), p.e63 (2018).

K.B. Karunakaran, S. Chaparala, M.K. Ganapathiraju, Potentially repurposable drugs for schizophrenia identified from its interactome, bioRxiv, 442640 (2018).

Y. Zhang, F. Liu, H. Xiao, X. Yao, G. Li, S.R. Choi, K. Ploessl, Z. Zha, L. Zhu, H.F. Kung, [18F] Diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain, Nuclear Medicine and Biology, 66, 1-9 (2018).

J. Cummings, C. Reiber, P. Kumar, The price of progress: Funding and financing Alzheimer's disease drug development, Alzheimer's & Dementia: Translational Research & Clinical Interventions, 4, 330-343 (2018).

A.L. Halberstadt, J.V. van der Zee, M. Chatha, M.A. Geyer, S.B. Powell, Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen, Psychopharmacology, 1-10 (2018).

P.M. McNeely, A.N. Naranjo, K. Forsten-Williams, A.S. Robinson, A2AR Binding Kinetics in the Ligand Depletion Regime, SLAS DISCOVERY: Advancing Life Sciences R&D, 22(2), 166–175 (2017).

E.K. Kirschmann, D.M. McCalley, C.M. Edwards, M.M. Torregrossa, Consequences of adolescent exposure to the cannabinoid receptor agonist WIN55,212-2 on working memory in female rats, Front. Behav. Neurosci., 11, 137, doi: 10.3389/fnbeh.2017.00137 (2017).

G.A. Kane, E.M. Vazey, R.C. Wilson, A. Shenhav, N.D. Daw, G. Aston-Jones, J.D. Cohen, Increased locus coeruleus tonic activity causes disengagement from a patch-foraging task, Cognitive, Affective, & Behavioral Neuroscience, 17, 6, 1073–1083 (2017),

E. Goubert, Y. Mircheva, F.M. Lasorsa, C. Melon, E. Profilo, J. Sutera, H. Becq, F. Palmieri, L. Palmieri, L. Aniksztejn, F. Molinari, Inhibition of the mitochondrial glutamate carrier SLC25A22 in astrocytes leads to intracellular glutamate accumulation, Front. Cell. Neurosci., 11, 149 (2017).

D.S. Goldstein, Y. Jinsmaa, P. Sullivan, Y. Sharabi, N-Acetylcysteine prevents the increase in spontaneous oxidation of dopamine during monoamine oxidase inhibition in PC12 cells, Neurochemical Research, 42/11, 3289–3295 (2017).

L.M. Carey, R.J. Rice, A.J. Prus, The neurotensin NTS1 receptor agonist PD149163 produces antidepressant?like effects in the forced swim test: further support for neurotensin as a novel pharmacologic strategy for antidepressant drugs, Drug Dev. Res., 78/5, 196-202 (2017).

T.J. Donahue, T.M. Hillhouse, K.A. Webster, R. Young, E.O. De Oliveira, J.H. Porter, Discriminative stimulus properties of the atypical antipsychotic amisulpride: comparison to its isomers and to other benzamide derivatives, antipsychotic, antidepressant, and antianxiety drugs in C57BL/6 mice, Psychopharmacology, 234, 23–24, 3507–3520 (2017).

T.J. Roelofs, J.P. Verharen, G.A. van Tilborg, L. Boekhoudt, A. van der Toorn, J.W. de Jong, M.C. Luijendijk, W.M. Otte, R.A. Adan, and R.M. Dijkhuizen, A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats: a proof-of-concept study on the mesocorticolimbic system, NeuroImage. 156, 109-118 (2017).

H.R. Modi, K. Ma, L. Chang, M. Chen, S.I. Rapoport, Valnoctamide, which reduces rat brain arachidonic acid turnover, is a potential non-teratogenic valproate substitute to treat bipolar disorder, Psychiatry Research, 254, 279-283 (2017).

Z. Chen, R. Liu, S.H. Yang, G.H. Dillon, R. Huang, Methylene blue inhibits GABA A receptors by interaction with GABA binding site, Neuropharmacology, 119, 100-110 (2017).

P. Ratano, M. Palmery, V. Trezza, P. Campolongo, Cannabinoid modulation of memory consolidation in rats: beyond the role of cannabinoid receptor subtype 1, Frontiers in Pharmacology, 8, 200 (2017).

P.S. Backlund, H.F. Urbanski, M.A. Doll, D.W. Hein, M. Bozinoski, C.E. Mason, S.L. Coon, D.C. Klein, Daily rhythm in plasma N-acetyltryptamine, Journal of Biological Rhythms, p.0748730417700458 (2017).

L. Boekhoudt, T.J.M. Roelofs, J.W. de Jong, A.E. de Leeuw, M.C.M. Luijendijk, I.G. Wolterink-Donselaar, G. van der Plasse, R.A.H. Adan, Does activation of midbrain dopamine neurons promote or reduce feeding? International Journal of Obesity, 41, 1131–1140 (2017).

F. Piacente, I., Caffa, S. Ravera, G. Sociali, M. Passalacqua, V.G. Vellone, P. Becherini, D., Reverberi, F. Monacelli, A. Ballestrero, P. Odetti, Nicotinic acid phosphoribosyltransferase regulates can cer cell metabolism, susceptibility to NAMPT inhibitors and DNA repair, Cancer Research, 3079. (2017).

W.C. Buchta, S.V. Mahler, B. Harlan, G.S. Aston?Jones, A.C Riegel, Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex, Physiological Reports, 5(6), e13198, DOI: 10.14814/phy2.13198 (2017).

L. Boekhoudt, E.S. Voets, J.P. Flores-Dourojeanni, M.C. Luijendijk, L.J. Vanderschuren, R.A. Adan, Chemogenetic activation of midbrain dopamine neurons affects attention, but not impulsivity, in the five-choice serial reaction time task in rats, Neuropsychopharmacology, 42(6), 1315-1325 (2017).

A.S. Undieh, Measurement of brain CDP-diacylglycerol synthase 1 enzyme and uses thereof, U.S. Patent 9,593,360 (2017).

K. Ye, Heterocyclic flavone derivatives, compositions, and methods related thereto, U.S. Patent 9,593,125 (2017).

A. Manduca, A. Bara, T. Larrieu, O. Lassalle, C. Joffre, S. Layé, O.J. Manzoni, Amplification of mGlu5-endocannabinoid signaling rescues behavioral and synaptic deficits in a mouse model of adolescent and adult dietary polyunsaturated fatty acid imbalance, Journal of Neuroscience, 37(29), pp.6851-6868 (2017).

Y. Cheng, C.C.Y. Huang, M. Tengfei, X. Wei, X. Wang, J. Lu, J. Wang, Distinct Synaptic Strengthening of the Striatal Direct and Indirect Pathways Drives Alcohol Consumption, Biol. Psychiatry, 81(11):918-929 (2017), doi:10.1016/j.biopsych.2016.05.016.

J.R. Yates, B.T. Gunkel, K.K. Rogers, M.N. Hughes, N.A. Prior, Effects of N-methyl-D-aspartate receptor ligands to sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure, Psychopharmacology, 234, 461-473 (2017).

P. Ratano, M. Palmery, V. Trezza, P. Campolongo, Cannabinoid modulation of memory consolidation in rats: beyond the role of cannabinoid receptor subtype 1, Frontiers in Pharmacology. Apr 12;8:200 (2017).

M. Matamales, Z. Skrbis, M.R. Bailey, P.D. Balsam, B.W. Balleine, J. Götz, J. Bertran-Gonzalez, A corticostriatal deficit promotes temporal distortion of automatic action in ageing, eLife, 6, doi: 10.7554/eLife.29908 (2017).

C.A. Campos, A.J. Bowen, S. Han, B.E. Wisse, R.D. Palmiter, M.W. Schwartz, Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus, Nature Neuroscience, 20, 934–942 (2017).

K.A. Herr, Sex differences in serotonergic and dopaminergic mediation of LSD discrimination in rats, Scholarworks Dissertations, Western Michigan University (2017).

J. Meszaros, Optical characterization of dopamine release in the globus pallidus and striatum, ProQuest Dissertations Publishing, Columbia University, 10637415 (2017).

R. J. Henry, D. M. Kerr, L. E. Flannery, M. Killilea, E.M. Hughes, L. Corcoran, D.P. Finn, M. Roche, Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1. Brain, Behavior, and Immunity, 62, 318-331 (2017).

G.M. Alexander, L.Y. Brown, S. Farris, D. Lustberg, C. Pantazis, B. Gloss, N.W. Plummer, N.V. Riddick, S.S. Moy, P. Jensen, S.M. Dudek, CA2 Neuronal activity controls hippocampal oscillations and social behavior, bioRxiv, 2017, 190504.

F.F. Steele III, S.C. Whitehouse, J.S. Aday, A.J. Prus, Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like effects in the 22-kHz ultrasonic vocalization model in rats, Brain Research, 1658, pp.31-35 (2017).

D.M. Kerr, A. Gilmartin, M. Roche, Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid, Pharmacological Research, 113, 228-235 (2016).

*P.M. Grace, K.A.Strand, E.L. Galer, D.J. Urban, X. Wang, M.V. Baratta, T.J. Fabisiak, N.D. Anderson, K. Cheng, L.I. Greene, D. Berkelhammer, Y. Zhang, A.L. Ellis, H.H. Yin, S. Campeau, K.C .Rice, B.L. Roth, S.F. Maier, L.R. Watkins, Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation, Proceedings of the National Academy of Sciences of the United States of America, 113(24), E3441–E345, doi:10.1073/pnas.1602070113 (2016).

N.J. Marchant, L.R. Whitaker, J.M. Bossert, B.K. Harvey, B.T. Hope, K. Kaganovsky, S. Adhikary, T.E. Prisinzano, E. Vardy, B.L. Roth, Y. Shaham, Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats, Neuropsychopharmacology, 41(2), 402–409 (2016),

K.S. Smith, D.J. Bucci, B.W. Luikart, S.V. Mahler, DREADDS: Use and application in behavioral neuroscience, Behavioral Neuroscience, 130(2), p.137 (2016).

M. Malik, C. Rangel-Barajas, R.H. Mach, R.R. Luedtke, The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice, Pharmacol. Biochem. & Behav. 148, 136-144 (2016).

D.S. Goldstein, Y. Jinsmaa, P. Sullivan, C. Holmes, I.J. Kopin, Y. Sharabi, 3, 4-Dihydroxyphenylethanol (Hydroxytyrosol) mitigates the increase in spontaneous oxidation of dopamine during monoamine oxidase inhibition in PC12 cells, Neurochemical Research, 41(9), 2173-2178 (2016).

M. Spoelder, A.M. Baars, M.D. Rotte, L.J. Vanderschuren, H.M. Lesscher, Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats, Psychopharmacology, 233(14), 2715-2725 (2016).

M.E. Denno, E. Privman, R.P. Borman, D.C. Wolin, B.J. Venton, Quantification of histamine and carcinine in Drosophila melanogaster tissues, ACS Chemical Neuroscience, 7(3), 407-414 (2016).

M. Cea, A. Cagnetta, C. Acharya, P. Acharya, Y.T., Tai, C. Yang, D. Lovera, D. Soncini, M. Miglino, G. Fraternali-Orcioni, L. Mastracci, Dual NAMPT and BTK targeting leads to synergistic killing of Waldenström macroglobulinemia cells regardless of MYD88 and CXCR4 somatic mutation status, Clinical Cancer Research, 22(24), 6099-6109 (2016).

A. Manduca, O. Lassalle, M. Sepers, P. Campolongo, V. Cuomo, G. Marsicano, B. Kieffer, L.J.J. Vanderschuren, V. Trezza, O.J. Manzoni, Interacting cannabinoid and opioid receptors in the nucleus accumbens core control adolescent social play, Frontiers in Behavioral Neuroscience, 10 (2016).

B.A. Davis, A. Nagarajan, L.R. Forrest, S.K. Singh, Mechanism of paroxetine (Paxil) inhibition of the serotonin transporter. Scientific Reports, 6: 23789 (2016).

J.B. Thomas, M. Vivancos, A.M. Giddings, R.W. Wiethe, K.R. Warner, A. Murza, É. Besserer-Offroy, J.M. Longpre, S.P. Runyon, A.M. Decker, B.P. Gilmour, Identification of 2-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1 H-pyrazol-3-yl] carbonyl} amino) tricyclo [3.3. 1.13, 7] decane-2-carboxylic acid (NTRC-844) as a selective antagonist for the rat neurotensin receptor type 2, ACS Chemical Neuroscience, 7(9), 1225-1231 (2016).

G. Sociali, L. Raffaghello, M. Magnone, F. Zamporlini, L. Emionite, L. Sturla, G. Bianchi, T. Vigliarolo, A. Nahimana, A. Nencioni, N. Raffaelli, Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model, Oncotarget, 7(3), 2968 (2016).

C. den Hartog, P. Zamudio-Bulcock, S. Nimitvilai, M. Gilstrap, B. Eaton, H. Fedarovich, A. Motts, J.J. Woodward, Inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice, Neuropharmacology, 107, 451-459 (2016).

E. Wicker, P.A, Forcelli, Chemogenetic silencing of the midline and intralaminar thalamus blocks amygdala-kindled seizures, Experimental Neurology, 283, 404-412 (2016).

L. Jiang, X. Wu, S. Wang, S.H. Chen, H. Zhou, B. Wilson, C.Y. Jin, R.B. Lu, K. Xie, Q. Wang, J.S. Hong, Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase, Journal of Neuroinflammation, 13(1), 110 (2016).

D.B. Pereira, Y. Schmitz, J. Mészáros, P. Merchant, G. Hu, S. Li, A. Henke, J.E. Lizardi-Ortiz, R.J. Karpowicz Jr, T.J. Morgenstern, M.S. Sonders, Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum, Nature Neuroscience, 19(4), 578 (2016).

A.M. Van Dyke, Serotonin receptor signaling following selective serotonin reuptake inhibitor treatment or: How I learned to stop worrying and love the agonist, University of Maryland, ProQuest Dissertations Publishing, 10118711 (2016).

M. Malik, C. Rangel-Barajas, R.H. Mach, R.R. Luedtke, The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice, Pharmacol. Biochem. & Behav., 148, 136-144 (2016).

J.B. Dwyer, F.M. Leslie, Adolescent maturation of dopamine D1 and D2 receptor function and interactions in rodents, PloS one, 11(1) (2016).

Y. Cheng, M. Pardo, S. Armini, A. Martinez, H. Mouhsine, J.-F. Zagury, R.S. Jope, E. Beurel, Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior, Brain, Behavior, and Immunity (2016).

M. Zhang, M. Li, Behavioral and pharmacological validation of an integrated fear-potentiated startle and prepulse inhibition paradigm, Behavioural Brain Res., 307, 176-185 (2016).

D. Wirtshafter, T.R. Stratford, Chemogenetic inhibition of cells in the paramedian midbrain tegmentum increases locomotor activity in rats, Brain Res., 1632, 98-106 (2016).

B.A. Davis, A. Nagarajan, L.R. Forrest, S.K. Singh, Mechanism of paroxetine (Paxil) inhibition of the serotonin transporter, Scientific Reports, 6 (2016).

A. Manduca, M. Servadio, R. Damsteegt, P. Campolongo, L.J.M.J. Vanderschuren, V. Trezza, Dopaminergic neurotransmission in the nucleus accumbens modulates social play behavior in rats, Neuropsychopharmacology, 41:2215-2223 (2016).

G.K. Ford, O. Moriarty, B.N. Okine, E. Tully, A. Mulcahy, B. Harhen, D.P. Finn, Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats, European J. of Pain, 19(8), 1177-1185 (2015).

P. Zanos, S.C. Piantadosi, H.-Q. Wu, H.J. Pribut, M.J. Dell, A. Can, H.R. Snodgrass, C.A. Zarate, R. Schwarcz, T.D. Gould, The prodrug 4-chlorokynurenine causes ketamine-like antidepressant effects, but not side effects, by NMDA/glycineB-site inhibition, J. Pharmacol. & Exp. Therap., 355(1), 76-85 (2015).

M. Morales, M.M. McGinnis, B.A. McCool, Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long–Evans rats, Pharmacol. Biochem. & Behav., 139, 67-76 (2015).

M.B. Pomrenze, E.Z. Millan, F.W. Hopf, R. Keiflin, R. Maiya, A. Blasio, J. Dadgar, V. Kharazia, G. De Guglielmo, E. Crawford, P.H. Janak, O. George, K.C. Rice, R.O. Messing, A transgenic rat for investigating the anatomy and function of corticotrophin releasing factor circuits, Frontiers in Neurosci., 9 (2015).

M.L. Berger, P. Rebernik, Differential influence of 7 cations on 16 non-competitive NMDA receptor blockers, Bioorg. & Med. Chem. Letts., 25(19), 4131-4135 (2015).

T. Scardochio, I. Trujillo-Pisanty, K. Conover, P. Shizgal, P.B.S. Clarke, The effects of electrical and optical stimulation of midbrain dopaminergic neurons on rat 50-kHz ultrasonic vocalizations, Frontiers in Behavioral Neurosci., 9 (2015).

L.E. Mueller, M.A. Kausch, T. Markovic, D.A.A. MacLaren, D.M. Dietz, J. Park, S.D. Clark, Intra-ventral tegmental area microinjections of urotensin II modulate the effects of cocaine, Behavioural Brain Res., 278, 271-279 (2015).

P. Yang, L. Zhang, Q-J. Shi, Y-B. Lu, M. Wu, E-Q Wei, W-P. Zhang, Nicotinamide phosphoribosyltransferase inhibitor APO866 induces C6 glioblastoma cell death via autophagy, Die Pharmazie-An Internat. J. of Pharmac. Sci., 70(10), 650-655 (2015).

B.T. Burrows, L.R. Watterson, M.A. Johnson, M.F. Olive, Effects of modafinil and R-modafinil on brain stimulation reward thresholds: implications for their use in the treatment of psychostimulant dependence, Journal of Drug and Alcohol Research, 4 (2015), doi:10.4303/jdar/235958.

A. Manduca, M. Morena, P. Campolongo, M. Servadio, M. Palmery, L. Trabace, M.N. Hill, L.J.M.J. Vanderschuren, V. Cuomo, V. Trezza, Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats, Eur. Neuropsychopharmacol., doi:10.1016/j.euroneuro.2015. 04.005.

E. Pearlstein, F.J. Michel, R. Cloarec, C. Hammond, Glutamatergic synaptic currents of nigral dopaminergic neurons follow a postnatal developmental sequence, Frontiers in Cellular Neuroscience, 9, 210 (2015).

Gero D, Szabo C. Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post?hypoxic cardiomyocytes, British J. Pharmacol. 172(20):4817-32 (2015).

J.A. Brown, T.S. Ramikie, M.J. Schmidt, R. Báldi, K. Garbett, M.G. Everheart, L.E. Warren, L. Gellért, S. Horváth, S. Patel, K. Mirnics, Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes, Molecular Psychiatry, doi:10.1038/mp.2014.192 (2015).

Y. Qiu, Y. Zhang, J-X. Li, Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats, Eur. J. Pharmacol., 749, 133–141 (2015).

H.G.S. Martin, O. Lassalle, J.T. Brown, O.J. Manzoni, Age-dependent long-term potentiation deficits in the prefrontal cortex of the Fmr1 knockout mouse model of Fragile X Syndrome, Cereb. Cortex, doi: 10.1093/cercor/bhv031 (2015).

M.A. Gannon, C.J. Brown, R.M. Stevens, M.S. Griffith, C.A. Marczinski, M.E. Bardgett, Early-life risperidone administration alters maternal–offspring interactions and juvenile play fighting, Pharmacol. Biochem. Behavior, 130, 90–96 (2015).

Y. Kawasaki, T. Fujita, K. Yang, E. Kumamoto, Anandamide Depresses Glycinergic and GABAergic Inhibitory Transmissions in Adult Rat Substantia Gelatinosa Neurons. Pharmacol. & Pharm. 6(3), 103-117 (2015).

L.G. Chastain, H. Qu, C.H. Bourke, P.M. Luvone, P.R. Dobner, C.B. Nemeroff, B. Kinkead, Striatal dopamine receptor plasticity in neurotensin deficient mice, Behav. Brain Res., 280, 160-171 (2015).

J.W. Lovelace, A. Corches, P.A. Vieira, K. Mackie, E. Korzus, An animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity, Neuropharmacology, 99, 242-255 (2015).

M. Feng, J. Gao, N. Sui, M. Li, Effects of central activation of serotonin 5-HT2A/2C or dopamine D2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test, Psychopharmacol., 232, 1219-1230 (2015).

J. Gao, R. Qin, M. Li, Repeated administration of aripiprazole produces a sensitization effect in the suppression of avoidance responding and phencyclidine-induced hyperlocomotion and increases D2 receptor-mediated behavioral function, J. Psychopharmacol., 29(4), 390-400 (2015).

J.O-Y. Yau, G.P. McNally, Pharmacogenetic excitation of dorsomedial prefrontal cortex restores fear prediction error, J. Neurosci., 35(1), 74-83 (2015).

S. Ding, L. Li, F.M. Zhou, Robust presynaptic serotonin 5-HT1B receptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatment, J. Neurophysiology, 113(9), 3397-3409 (2015).

A. Maffei, A.M. Segal, J.C. Alvarez-Perez, A. Garcia-Ocaña, P.E. Harris, Anti-incretin, anti-proliferative action of dopamine on beta-cells, Molecular Endocrinology, 29(4), 542–557 (2015).

A. Cagnetta, D. Soncini, I. Caffa, C. Acharya, P. Acharya, S. Adamia, I. Pierri, M. Bergamaschi, A. Garuti, G. Fraternali-Orcioni, A. Provenzani, L. Mastracci, C. Zucal, G. Damonte, APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells. Clin. Cancer Res. 21(17), 3934-3945 (2015).

Y.E. Ogbonmwan, J.P. Schroeder, P.V. Holmes, D. Weinshenker, The effects of post-extinction exercise on cocaine-primed and stress-induced reinstatement of cocaine seeking in rats. Psychopharmacol. 232, 1395-1403 (2015).

J.B. Thomas, A.M. Giddings, S. Olepu, R.W. Wiethe, K.R. Warner, P. Sarret, J-M. Longpre, S.P. Runyon, B.P. Gilmour, The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2. Bioorg. Med. Chem. Lett. 25(10), 2060–2064 (2015).

J.B. Thomas, A.M. Giddings, S. Olepu, R.W. Wiethe, D.L. Harris, S. Narayanan, K.R. Warner, P. Sarret, J-M. Longpre, S.P. Runyon, B.P. Gilmour, Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Bioorg. Med. Chem. Lett. 25(2), 292–296 (2015).

M. Malik, C. Rangel-Barajas, N. Sumien, C. Su, M. Singh, Z. Chen, R-Q. Huang, J. Meunier, T. Maurice, R.H. Mach, R.R. Luedtke, The effects of sigma-1 receptor selective ligands on muscarinic receptor antagonist induced cognitive deficits in mice, Brit. J. Pharmacol., 172(10), 2519–2531 (2015).

C. Anaclet, N.P. Pedersen, L.L. Ferrari, A. Venner, C.E. Bass, E. Arrigoni, P.M. Fuller, Basal forebrain control of wakefulness and cortical rhythms, Nat. Commun. Nov 3;6:8744 (2015). doi: 10.1038/ncomms9744.

J. Zhang, Z. Teng, Y. Song, M. Hu, C. Chen, Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury, J. Cereb. Blood Flow Metab. 35(3):443-53 (2015).

S.E. Chang, T.P. Todd, D.J. Bucci, K.S. Smith, Chemogenetic manipulation of ventral pallidal neurons impairs acquisition of sign-tracking in rats, Eur. J. Neurosci. 42(12):3105-16 (2015).

Y. Song, J. Zhang, C. Chen, Fine-tuning of synaptic upscaling at excitatory synapses by endocannabinoid signaling is mediated via the CB1 receptor, Scientific Reports, 5(1), pp.1-9 (2015).

S. Robinson, T.P. Todd, A.R. Pasternak, B.W. Luikart, P.D. Skelton, D.J. Urban, D.J. Bucci, Chemogenetic silencing of neurons in retrosplenial cortex disrupts sensory preconditioning, J Neurosci. 2014,34(33):10982-8. doi: 10.1523/JNEUROSCI.1349-14.2014.

K. A. Jacobson,F. Ciruela, Synthesis of the adenosine A2A receptor fluorescent agonist MRS5424, Bio-protocol, 4(6), e1069-e1069 (2014).

J. Zhang, M. Hu, Z. Teng, Y.P. Tang, C. Chen, Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease, J. Neurosci. 34(45):14919-14933 (2014).

A. Thomazeau, O. Lassalle, J. Iafrati, B. Souchet, F. Guedj, N. Janel, P. Chavis, J. Delabar, O.J. Manzoni, Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a, J. Neurosci. 2014 Jan 22;34(4):1138-47. doi: 10.1523/JNEUROSCI.2852-13.2014.

C. Anaclet, L. Ferrari, E. Arrigoni, C.E. Bass, C.B. Saper, J. Lu, P.M. Fuller, The GABAergic parafacial zone is a medullary slow wave sleep-promoting center, Nat. Neurosci. Sep;17(9):1217-24. doi: 10.1038/nn.3789. Epub 2014 Aug 17. PMID: 25129078.

E.K. Stephens, D. Avesar, A.T. Gulledge, Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex, Frontiers in Neural Circuits, 8:97 (2014), doi: 10.3389/fncir.2014.00097.

Bello, N.T., Yeh, C.Y., Verpeut, J.L. and Walters, A.L., Binge-like eating attenuates nisoxetine feeding suppression, stress activation, and brain norepinephrine activity, PLoS One, 9(4), p.e93610 (2014).

Q. Shu, R. Qin, Y. Chen, G. Hu, M. Li, Asenapine sensitization from adolescence to adulthood and its potential molecular basis, Behav. Brain Res., 273, 166-176 (2014).

B.C. Shonesy, R.J. Bluett, T.S. Ramikie, R. Báldi, D.J. Hermanson, P.J. Kingsley, L.J. Marnett, D.G. Winder, R.J. Colbran, Sachin Patel, Genetic Disruption of 2-Arachidonoylglycerol Synthesis Reveals a Key Role for Endocannabinoid Signaling in Anxiety Modulation. Cell Reports, 9(5), 1644–1653 (2014).

J.S. Dileep Kumar, V. Arango, S. Kassir, J. Prabhakaran, V. Majo, N. Simpson, V. Johnson, M. Underwood, J. Mann, In vitro binding of [3H]CUMI-101, a HT1AR radioligand in Alzheimer’s disease. J. Nucl. Med. 55(1), 1819 (2014).

H.R. Modi, M. Basselin, S.I. Rapoport, Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4. Bipolar Disorders, 16(8), 875–880 (2014).

B. Riffault, I. Medina, C. Dumon, C. Thalman, N. Ferrand, P. Friedel, J-L. Gaiarsa, C. Porcher, Pro-Brain-Derived Neurotrophic Factor Inhibits GABAergic Neurotransmission by Activating Endocytosis and Repression of GABAA Receptors. J. Neurosci. 34(40):13516–13534 (2014).

D. Guimond, D. Diabira, C. Porcher, F. Bader, N. Ferrand, M. Zhu, S.M. Appleyard, G.A. Wayman, J-L. Gaiarsa, Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus, Frontiers Cell. Neurosci. 8(235):1-17 (2014).

H.G.S. Martin, O. Manzoni, Late onset deficits in synaptic plasticity in the valproic acid rat model of autism, Front. Cell. Neurosci., 8 (23), 1-8 (2014).

C.L. Pickens, F.R. Theberge; Blockade of CB1 receptors prevents retention of extinction but does not increase low preincubated conditioned fear in the fear incubation procedure, Behavioural Pharmacology, 2014, 25 (1), 23-31.

A.J. Prus, C.J. Schuck, K.R. Rusch, and L.M. Carey, The discriminative stimulus effects of the neurotensin NTS1 receptor agonist PD149163 in rats: stimulus generalization testing with dopamine D1 and D2 receptor ligands, Drug Dev. Res., 75 (2) 47-58 (2014).

J. Koci, L. Šimo, and Y. Park, Autocrine/paracrine dopamine in the salivary glands of the blackegged tick lxodes scapularis, J. Insect Physiology, 62, 39-45 (2014).

C. Rangel-Barajas, M. Malik, S. Vangveravong, R.H. Mach, and R.R. Luedtke, Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in make DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds, Neuropharmacology, 83, 18-27 (2014).

K. Rea, G.K. Ford, W.M. Olango, B. Harhen, M. Roche, and D.P. Finn, Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state, Eur, J. Neurosci., 39 (3) 435-443 (2014).

M.J. Duncan, K.M. Franklin, X. Peng, C. Yun, and S.J. Legan, Circadian rhythm disruption by a novel running wheel: Roles of exercise and arousal in blockade of the luteinizing hormone surge, Physiology & Behavior, 131, 7-16 (2014).

M.J. Duncan, K.M. Franklin, X. Peng, C. Yun, S.J. Legan, Circadian rhythm disruption by a novel running wheel: Roles of exercise and arousal in blockade of the luteinizing hormone surge, Physiol. & Behav., 131, 7-16 (2014).

D Soncini, I Caffa, G Zoppoli, M Cea, A Cagnetta, M Passalacqua, L Mastracci, S Boero, F Montecucco, G Sociali, D Lasigliè, P Damonte, A Grozio, E Mannino, A Poggi, V D'Agostino, F Monacelli, A Provenzani, P Odetti, A Ballestrero, S Bruzzone, A. Nencioni, Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity, J. Biological Chem., 289(49), 34189-34204 (2014).

A.E. Chávez, V.M. Hernández, A. Rodenas-Ruano, C.S. Chan, P.E. Castillo, Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus, J. Neurosci., 34(50), 16621-16629 (2014).

A. Manduca, M. Servadio, P. Campolongo, M. Palmery, L. Trabace, L.J.M.J. Vanderschuren, V. Cuomo, V. Trezza, Strain-and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats, Eur. Neuropsychopharmacol., 24(8), 1337–1348 (2014).

A.A. Keiser, K.S. Matazel, M.K. Esser, D. Feifel, A.J. Prus, Systemic administration of the neurotensin NTS?-receptor agonist PD149163 improves performance on a memory task in naturally deficient male Brown Norway rats, Exp. & Clin. Psychopharmacol., 22(6), 541 (2014).

R.J. Bluett, J.C. Gamble-George, D.J. Hermanson, N.D. Hartley, L.J. Marnett, S. Patel, Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. Transl. Psychiatry, 4, e408, doi:10.1038/tp.2014.53 (2014).

Y. Qiu, X.H. He, Y. Zhang, J.X. Li, Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats, Sci. Reports, 4, doi:10.1038/srep06605 (2014).

T.J. Donahue, T.M. Hillhouse, K.A. Webster, R. Young, E.O. De Oliveira, J.H. Porter, (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics, Eur. J. Pharm., 734, 15-22 (2014).

C. Rangel-Barajas, M. Malik, S. Vangveravong, R.H. Mach, R.R. Luedtke, Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds, Neuropharmacol., 83, 18-27 (2014).

A.J. Prus, T.M. Hillhouse, A.L. LaCrosse, Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats, Prog. Neuropsychopharmacol. Biol. Psychiatry, 49, 78-84 (2014).

T.M. Hillhouse, Z. Shankland, K.S. Matazel, A.A. Keiser, A. J. Prus, The quetiapine active metabolite N-desalkylquetiapine and the neurotensin NTS? receptor agonist PD149163 exhibit antidepressant-like effects on operant responding in male rats, Exp. & Clin. Psychopharm., 22(6), 548 (2014).

T.J. Younts, V. Chevaleyre, P.E. Castillo, CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses. J. Neurosci. 33(34):13743-57 (2013).

L. Šimo, J. Koci, D. Kim, Y. Park; Invertebrate Specific D1-like Dopamine Receptor in Control of Salivary Glands in the Black-Legged Tick Ixodes scapularis, J. Comparative Neurol. Accepted: Dec 02, 2013, doi: 10.1002/cne.23515.

R. Qin, Y. Chen, M. Li; Repeated asenapine treatment produces a sensitization effect in two preclinical tests of antipsychotic activity, Neuropharmacology 2013, 75, 356–364.

S. Di, I.R. Popescu, J.G. Tasker; Glial control of endocannabinoid heterosynaptic modulation in hypothalamic magnocellular neuroendocrine cells, J. Neurosci, 2013, 33(46), 18331-18342.

M. Häring, M. Grieb, K. Monory, B. Lutz, F.A. Moreira, Cannabinoid CB1 receptor in the modulation of stress coping behavior in mice: the role of serotonin and different forebrain neuronal subpopulatins, Neuropharmacology, 65, 83-89 (2013)

M. Feng, N. Sui, M. Li, Environmental and behavioral controls of the expression of clozapine tolerance: evidence from a novel across-model transfer paradigm, Behav. Brain Res., 238, 178-187 (2013)

E.C. Berglund, N.J. Kuklinski, E. Karagündüz, K. Ucar, J. Hanrieder, A.G. Ewing, Freeze-drying as sample preparation for micellar electrokinetic capillary chromatography-electrochemical separations of neurochemicals in Drosophila brains, Anal. Chem., 85(5), 2841-2846 (2013)

H.R. Modi, A.Y. Taha, H.W. Kim, L. Chang, S.I. Rapoport, Y. Cheon, Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability, J. Neurochem., 124(3), 376-387 (2013)

J.S. Kumar, R.V. Parsey, S.A. Kassir, V.J. Majo, M.S. Milak, J. Prabhakaran, N.R. Simpson, M.D. Underwood, J.J. Mann, V. Arango, Autoradiographic evaluation of [3H]CUMI-101, a novel, selective 5-HT1AR ligand in human and baboon brain, Brain Res., 1507, 11-18 (2013)

H. Shen, H. Igarashi, N. Imamura, N. Matsuki, H. Nomura, N-methyl-D-aspartate receptors and protein synthesis are necessary for reinstatement of conditioned fear, Neuroreport., Jun 28 (2013)

A.R. Abela, S.D. Dougherty, E.D. Fagen, C.J. Hill, Y. Chudasama, Inhibitory control deficits in rats with ventral hippocampal lesions, Cereb. Cortex, 23(6), 1396-1409 (2013)

Z. Li, S.F. Schmidt, J.M. Friedman, Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth, Diabetes, 62(7), 2359-2367 (2013)

D.A. Stidd, K. Vogelsang, S.E. Krahl, J.P. Langevin, and J.M. Fellous, Amygdala deep brain stimulation is superior to paroxetine treatment in a rat model of posttraumatic stress disorder, Brain Stimul., Jun 25 (2013)

A. Salykin, P. Kuzmic, O. Kyrylenko, J. Musilova, Z. Glatz, P. Dvorak, and S. Kyrylenko, Nonlinear regression models for determination of nicotinamide adenine dinucleotide content in human embryonic stem cells, Stem Cell Rev., July 6 (2013)

A. Cagnetta, M. Cea, T. Calimeri, C. Acharya, M. Fulciniti, Y.T. Tai, T. Hideshima, D. Chauhan, M.Y. Zhong, F. Patrone, A. Nencioni, M. Gobbi, P. Richardson, N. Munshi, K.C. Anderson, Intracellular NAD+-depletion enhances bortezomib-induced anti-myeloma activity, Blood., 3(7) PMID:23823317 (2013)

I. Miederer, S. Maus, I. Zwiener, G. Podopryorina, D. Meschcheryakov, B. Lutz, M. Schreckenberger, Evaluation of cannabinoid type 1 receptor expression in the rat brain using [18F]MK-9470 micro PET, Eur. J. Nucl. Med. Mol. Imaging, July 9 (2013)

A. Grozio, G. Sociali, L. Sturla, I. Caffa, D. Soncini, A. Salis, N. Raffaelli, A. DeFlora, A. Nencioni, S. Bruzzone, CD73 as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells, J. Biol. Chem., doi:10.1074/jbc.M113.470435 (2013)

J. Hannestad, N. Dellagioia, J.D. Gallezot, K. Lim, N. Nabulsi, I. Esterlis, B. Pittman, J.Y. Lee, K.C. O’Connor, D. Pelletier, R.E. Carson, The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study, Brain Behav. Immun., doi:1016/j.bbi. (2013)

Q. Shu, G. Hu, M. Li, Is brain-derived neurotrophic factor a possible mechanism underlying risperidone sensitization in adolescent rats, Biochem. & Pharmacol., S1, doi:10.4172/2167-0501.S1-004 (2013)

D. Höfelmann, B. di Benedetto, S.C. Azad, V. Micale, C.T. Wotjak, G. Rammes, Lack of interaction of endocannabinoids and 5-HT3 neurotransmission in associative fear circuits of the amygdala: Evidence from electrophysiological and behavioural experiments, Brain Res., 1527, 47-56 (2013)

P. Singh, T.W. Fletcher, Y. Li, N.J. Rusch, F. Kilic, Serotonin uptake rates in platelets from angiotensin II-induced hypertensive mice, Health, 5(4A), 31-39 (2013)

R. Hovius, Characterization and Validation of Fluorescent Receptor Ligands: A Case Study of the Ionotropic Serotonin Receptor, Chemical Neurobiology, Humana Press, 2013, Chapter 12, 161-178.

M. Haddad, Do CB1 Cannabinoid Receptors Regulate Insulin Signalling in Rat Primary Skeletal Muscle Cells? J. Phys. Pharm. Adv. 2013, 3(12), 277-291.

A. Grozio, G. Sociali, L. Sturla, I. Caffa, D. Soncini, A. Salis, N. Raffaelli, A. De Flora, A. Nencioni, S. Bruzzone; CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells, J. Biolog. Chem. 2013, 288, 25938-25949.

B. Bosier, L. Bellocchio, M. Metna-Laurent, E. Soria-Gomez, I. Matias, E. Hebert-Chatelain, A. Cannich, M. Maitre, T. Leste-Lasserre, P. Cardinal, J. Mendizabal; Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes, Molecular Metabolism 2013, 2 (4), 393–404.

Bello, N.T., Walters, A.L., Verpeut, J.L. and Cunha, P.P., High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor, Journal of Obesity, 2013, 457047.

T.M. Hillhouse & A.J. Prus, Effects of the neurotensin NTS(1) receptor agonist PD149163 on visual signal detection in rats, Eur. J. Pharmacol., 721(1-3), 201-207 (2013).

C. Agulhon, K.M. Boyt, A.X. Xie, F. Friocourt B.L. Roth, K.D. McCarthy, Modulation of the autonomic nervous system and behaviour by acute glial cell Gq protein-coupled receptor activation in vivo. J. Physiol. 591(22):5599–5609 (2013), doi:10.1113/jphysiol.2013.261289.

R. Chen, J. Zhang, N. Fan, Z. Teng, Y. Wu, H. Yang, Y. Tang, H. Sun, Y. Song, C. Chen, delta-9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell, 155: 1154-1165 (2013).

R. Chen, J. Zhang, Y. Wu, D. Wang, G. Feng, Y.P. Tang, Z. Teng, C. Chen, Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease, Cell Rep. Nov 29;2(5):1329-39 (2012).

P. Campolongo, V. Trezza, The endocannabinoid system: a key modulator of emotions and cognition, Frontiers in Behavioral Neuroscience, 6:73 (2012).

D. Avesar, A.T. Gulledge, Selective serotonergic excitation of callosal projection neurons, Frontiers in Neural Circuits, 6:12 (2012), doi:10.3389/fncir.2012.00012.

D. Avesar, A.T. Gulledge, Selective serotonergic excitation of callosal projection neurons, Frontiers in Neural Circuits, 6:12 (2012), doi:10.3389/fncir.2012.00012.

M. Magnone, I. Bauer, A. Poggi, E. Mannino, L. Sturla, M. Brini, E. Zocchi, A. De Flora, A. Nencioni*, S. Bruzzone*; NAD+ Levels Control Ca2+ Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes, J. Biol. Chem. 2012, 287, 21067-21081.

C. Cottingham, X. Li, Q. Wang, Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrentin3 and spinophilin, Neuropharmacology, 62(7), 2354-2362 (2012)

F.J. Meye, V. Trezza, L.J. Vanderschuren, G.M. Ramakers, R.A. Adan, Neutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity, Mol. Psychiatry, Oct. 16, diol: 10.1038/mp.2012.145 (2012)

M. Cea, A. Cagnetta, M. Fulciniti, Y.T. Tai, T. Hideshima, D. Chauhan, A. Roccaro, A. Sacco, T. Calimeri, F. Cottini, J. Jakubikova, S.Y. Kong, F. Patrone, A. Nencioni, M. Gobbi, P. Richardson, N. Munshi, K.C. Anderson, Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition, Blood, 120(17), 3519-3529 (2012)

C. He, X. Qu, J. Wan, R. Rong, L. Huang, C. Cai, K. Zhou, Y. Gu, S.Y. Qian, J.X. Kang, Inhibiting delta-6 desaturase activity suppresses tumor growth in mice, PLoS One, 7(10), e47567 (2012)

E. Beurel, M.A. Mines, L. Song, R.S. Jope, Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development, Bipolar Disord., 14(8), 822-830 (2012)

E.A. Stone, Y. Lin and Y. Sarfraz, Toward the Rapid Treatment of Depression by Selective Inhibition of Central Stress Circuits, The Open Neuropsychopharmacology Journal, 5, 9-17 (2012).

C. Zhang, M. Li; Contextual and behavioral control of antipsychotic sensitization induced by haloperidol and olanzapine, Behav Pharmacol. 2012, 23 (1), 66–79.

M. Li, W. He, R. Munro; Differential effects of acute amphetamine and phencyclidine treatment and withdrawal from repeated amphetamine or phencyclidine treatment on social interaction and social memory in rats, PsyCh Journal, 2012, 1 (1), 56–68.

J.Y. Xu, J. Zhang, C. Chen; Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids, J. Physiology, 2012, 590, 2305–2315.

K.A. Jacobson, Y. Kim, A. Klutz, B. Hechler, C. Gachet; Dendrimer conjugates of agonists and antagonists of the GPCR superfamily, US Patent 8,153,781 B2 (2012).

K.A. Jacobson, J. Jiang, Y. Kim, Y. Karton; Dihydropyrine-, Pyridine-, Benzopyran- One- and Triazoloquinazoline Derivative, Their Preparation and Their Use as Adenosine Receptor Antagonists, European Patent EP0885192 (2012).

A.L. Frederick, T.P. Saborido, G.D. Stanwood, Neurobehavioral phenotyping of G?q knockout mice reveals impairments in motor functions and spatial working memory without changes in anxiety or behavioral despair, Front. Behav. Neurosci., 6, 29-37 (2012)

N.M. Midde, A.M. Gomez, J. Zhu, HIV-1 Tat protein decreases dopamine transporter cell surface expression and vesicular monoamine transporter-2 function in rat striatal synaptosomes, J. Neuroimmune Pharmacol., 7(3), 629-639 (2012)

E. Ziu, C.P. Mercado, Y. Li, P. Singh, B.A. Ahmed, S. Freyaldenhoven, S. Lensing, J. Ware, F. Kilic, Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serontonin, J. Mol. Cell. Cardiol., 52, 1112-1121 (2012)

J. Hannestad, J-D. Gallezot, T. Schafbauer, K. Lim, T. Kloczynski, E.D. Morris, R.E. Carson, Y-S. Ding, K.P. Cosgrove, Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates, NeuroImage, 63, 232-239 (2012)

A.A. Williams, W.M. Ingram, S. Levine, J. Resnik, C.M. Kmel, J.R. Lish, D.I. Elizalde, S.A. Janowski, J. Shoker, A. Kozlenkov, J. Gonzalez-Maeso, A.L. Gallitano; Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine, Neuropsychopharmacol. 37, 2285-2298 (2012).

E. Ramadan, M. Basselin, J.S. Rao, L. Chang, M. Chen, K. Ma, S. Rapoport, Lamotrigine blocks NMDA receptor-initiated arachidonic acid signalling in rat brain: implications for its efficacy in bipolar disorder, Int. J. Neuropsychopharmacol., 15(7), 931-943 (2012)

R.T. Olszewski, K.J. Janczura, S.R. Ball, J.C. Madore, K.M. Lavin, JC-M. Lee, M.J. Lee, E.K. Der, T.J. Hark, P.R. Farago, C.P. Profaci, T. Bzdega, and J.H. Neale, NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia, TranslPsychiatry, 2, e145; doi:10.1038/tp.2012.68; published online 31 July (2012)

M. Magnone, I. Bauer, A. Poggi, E. Mannino, L. Sturla, M. Brini, E. Zocchi, A. De Flora, A. Nencioni, S. Bruzzone, NAD+ levels control Ca2+ by cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes, J. Biol. Chem., 287(25), 21067-21081 (2012)

A. Guillemette, M.A. Dansereau, N. Beaudet, E. Richelson, P. Sarret, Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain, Eur. J. Pain, 16(4), 473-484 (2012)

M.D. Carter, M.W. Calcutt, B.A. Malow, K.L. Rose, D.L. Hachey, Quantitation of melatonin and n-acetylserotonin in human plasma by nanoflow LC-MS/MS and electrospray, J. Mass Spectrom., 47, 277-285 (2012)

E.A. Stone, Y. Lin, Y. Sarfraz, Toward the treatment of depression by selective inhibition of central stress circuits, The Open Neuropsychopharmacology, 5, 9-17 (2012)

H-S. Huang, J.A. Allen, A.M. Mabb, I.F. King, J. Miriyala, B. Taylor-Blake, N. Sciaky, J.W. Dutton, H-M. Lee, X. Chen, J. Jin, A.S. Bridges M.J. Zylka, B.L. Roth, B.D. Philpot, Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons, Nature, 481, 185-189 (2012)

L-Y. Zhang, L-Y. Lui, L-L. Qie, K-N. Ling, L-H. Xu, F. Wang, S-H. Fang, Y-B. Lu, H. Hu, E-Q. Wei, W-P. Zhang, Anti-proliferation effect of APO866 on C6 glioblastoma cells by inhibiting nicotinamide phosphoribosyltransferase, Euro. J. Pharmacol., 674, 163-170 (2012)

A.M. Polter, S. Yang, R.S. Jope, X. Li, Functional significance of glycogen synthase kinase-3 regulation by serotonin, Cellular Signalling, 24, 265-271 (2012)

M. Bajzer, M. Olivieri, M.K. Haas, P.T. Pfluger, I.J. Magrisso, M.T. Foster, M.H. Tschop, K.A. Krawczewski-Carhuatanta, D. Cota, S. Obici, Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice, Diabetologia, 54(12), 3121-3131 (2011)

E.J. Downer, E. Clifford, B. Gran, H.J. Ne, P.G. Fallon, P.N. Moynagh, Identification of the synthetic cannabinoid R(+)WIN55m212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression, J. Biol. Chem., 286(12), 10316-10328 (2011)

C. Zhang, Y. Fany, M. Li, Olanzapine and resperidone disrupt conditioned avoidance responding by selectively weakening motivational salience of conditioned stimulus: Further evidence, Pharmacol. Biochem. Behav., 987, 155-160 (2011)

D.M. Lindquist, R.S. Dunn, K.M. Cecil, Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study, Schizophr. Res., 128, 83-90 (2011)

A. Nikiforov, C. Dolle, M. Niere, M. Ziegler, Pathways and subcellular compartmentation of NAD biosynthesis in human cells, J. Biol. Chem., 286(24), 21767-21778 (2011)

M.Cea, D.Soncini, F.Fruscione, L.Raffaghello, A.Garuti, L.Emionite, E.Moran, M.Magnone, G.Zoppoli, D.Reverberi, Caffa, Salis, Cagnetta, Bergamaschi, Casciaro, Pierri, G.Daonte, Ansaldi, Gobbi, Pistoia, Ballestrero, Patrone, Bruzzone, Nencioni, Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells, PloS one, 6(7), e22739 (2011)

M. Palner, M.D. Underwood, D.J.S. Kumar, V. Arango, G.M. Knudsen, J.J. Mann, R.V. Parsey, Ex vivo evaluation of the Serotonin 1A receptor partial agonist [3H]CUMI-101 in awake rats, Synapse, 65, 715-723 (2011)

M-E.F. Mohamed, R.F. Frye, Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities, Drug Metab. Dispos., 39, 1522-1528 (2011)

K. Tomiyama, H.A. Kim, A. Kinsella, M.E. Ehrlich, G. Schutz, N. Koshikawa, A.J. Lawrence, J.L. Waddington, J. Drago, Phenotypic disruption to orofacial movement topography in conditional mutants with generalized CamKIIa/Cre D1Tox versus striatal-specific DARPP-32/Cre D1 Tox ablation of D1 dopamine receptor-expressing cells, Synapse, 65, 835-842 (2011)

W. Wang, F. Wang, Y-J. Yang, Z-L. Hu, L-H. Long, H. Fu, N. Xie, J-G. Chen; The flavonoid baicalein promotes NMDA receptor-dependent long-term potentiation and enhances memory, Brit. J. Pharmacol. 2011, 162, 1364–1379.

M.V. Madsen, L.P. Peacock, T. Werge, M. B. Andersen, J.T. Andreasen; Effects of cannabinoid CB1 receptor agonism and antagonism on SKF81297-induced dyskinesia and haloperidol-induced dystonia in Cebus apella monkeys, Neuropharmacology, 2011, 60 (2–3), 418–422.

M. Li, E. He, N. Volf; Time course of the attenuation effect of repeated antipsychotic treatment on prepulse inhibition disruption induced by repeated phencyclidine treatment, Pharmacol. Biochem. & Behav. 2011, 98 (4), 559–569.

J.M. Wiebelhaus, K.A. Webster, H.Y. Meltzer, J.H. Porter; The metabolites N-desmethylclozapine and N-desmethylolanzapine produce cross-tolerance to the discriminative stimulus of the atypical antipsychotic clozapine in C57BL/6 mice, Behavioural Pharmacology, 2011, 22, 5-6, 458–467.

E.M. Goellner, B. Grimme, A.R. Brown, Y.C. Lin, X.H. Wang, K.F. Sugrue, L. Mitchell, R.N. Trivedi, J. Tang, R.W. Sobol; Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD+ Biosynthesis and Base Excision Repair, Cancer Research, 2011, 71, 2308.

M. Li, W. He, J. Chen; Time course of prepulse inhibition disruption induced by dopamine agonists and NMDA antagonists: effects of drug administration regimen, Pharmacol. Biochem. & Behav. 2011, 99 (3), 509–518.

E.N. Holly, B. Ebrecht, A.J. Prus, The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in rats, Eur. Neuropsychopharmacol., 21(7), 526-531 (2011).

D. Hauer, P. Ratano, M. Morena, S. Scaccianoce, I. Briegel, M. Palmery, V. Cuomo, B. Roozendaal, G. Schelling, P. Campolongo, Propofol enhances memory formation via an interaction with the endocannabinoid system, The Journal of the American Society of Anesthesiologists, 114(6), 1380-1388 (2011), doi:10.1097/ALN.0b013e31821c120e.

H. Du, X. Chen, J. Zhang, C. Chen, Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated by PPAR-gamma, British Journal of Pharmacology, 163:1533-1549 (2011).

X. Chen, J. Zhang, C. Chen, Endocannabinoid 2-arachidonoylglycerol protects neurons against beta-amyloid insults, Neuroscience, 178:159-168 (2011).

J. Xu, R. Chen, J. Zhang, C. Chen, Endocannabinoids differentially modulate long-term depression in rat hippocampal CA1 pyramidal neurons. PLoS ONE, 5:e10306 (2010).

M. Hill, S. Patel, P. Campolongo, J. Tasker, C. Wotjak, J. Bains, Functional interactions between stress and the endocannabinoid system: From synaptic signalling to behavioral ouput, The Journal of Neuroscience, 30(45):14980-6 (2010).

Desai, R.I., Bergman J., Drug discrimination in methamphetamine-trained rats: effects of cholinergic nicotinic compounds, J Pharmacol Exp Ther., Dec;335(3):807-16 (2010), doi: 10.1124/jpet.1.

M.R. Kilbourn, Rat pancreas uptake of [11C]dihydrotetrabenazine stereoisomers, Nuclear Medicine and Biology 37, 869-871 (2010)

K. Tomiyama, L.Song, M. Kobayashi, A. Kinsella, T. Kanematsu, M, Hirara, N. Koshikawa, J.L. Waddington, Orofacial movements in phospholipase C-related catalytically inactive protein-1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D1 dopamine receptor agonist SKF 83959, Synapse, 64, 714-720 (2010)

N.J. Kuklinski, E.C. Berglund, J. Engelbrektsson, A.G. Ewing, Biogenic amines in microdissected brain regions of Drosophila melanogaster measured with micellar electrokinetic capillary chromatography-electrochemical detection, Analytical Chemistry, 82(18), 7729-7735 (2010)

S. Walsh, A.M.Gorman, D.P. Finn, E. Dowd, The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats, Brain Research, 1363, 40-48 (2010)

J.A. Hern, A.H. Baig, G.I. Mashanov, B. Birdsall, J.E.T. Corrie, S. Lazareno, J.E. Molloy, N.J.M. Birdsall, Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules, Proc. Natl. Acad. Sci. 107/6, 2693–2698 (2010).

M. Weber, W.L. Chang, M.R. Breier, A. Yang, M.J. Millan, and N.R. Swerdlow, The Effects of the Dopamine D2 agonist sumanirole on prepulse inhibition in rats, European Neuropsychopharacology, 20, 421-425 (2010)

N. Fan, H. Yang J. Zhang, and C. Chen, Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivo delta9-THC exposure-impaired hippocampal synaptic plasticity, J. of Neurochemistry, 112 (3), 691-702 (2010)

N. Sang, J. Zhang, and C. Chen, Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway, Neurochemistry International, 56, 590-596 (2010)

T. Sun, C. Zhao, G. Hu, and M. Li, Iptakalim: A potential antipsychotic drug with novel mechanisms?, Eur. J. Pharmacology, 634, 68-76 (2010)

A. Das, G.J. Sanjayan, M. Kecskes, L. Yoo, Z.G. Gao, and K.A. Jacobson, Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists, J. Nanobiotechnology, 8, 11-29 (2010)

J.B. Tang, E.M. Goeliner, X.H. Wang, R.N. Trivedi, C.M. St. Croix, E. Jelezcova, D. Svilar, A.R. Brown, and R.W. Sobol, Bioenergetic Metabolites Regulate Base Excision Repair-Dependent Cell Death in Response to DNA Damage, Molecular Cancer Research, 8 (1), 67-79 (2010)

E.L. Dimitrox, E. Petrus, and T.B. Usdin, Tuberoinfundibula peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception, Experimental Neurology, 226, 68-83 (2010)

M. Lafrance, G. Roussy, K. Belleville, H. Maeno, N. Beaudet, K. Wada, and P. Sarret, Involvement of NTS2 receptors in stress-induced analgesia, Neuroscience, 166, 639-652 (2010)

G. Zoppoli, M. Cea, D. Soncini, F. Fruscione, J. Rudner, E. Moran, I. Caffa, D. Bedognetti, G. Motta, R. Ghio, F. Ferrando, A. Ballestrero, S. Parodi, C. Belka, F. Patrone, S. Bruzzone, and A. Nencioni, Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells, Experimental Hematology 38, 979-988 (2010)

L. Zhu, Y. Liu, K. Plossl, B. Lieberman, J. Liu, and H.F. Kung, An Improved radiosynthesis of [18F]AV-133: a PET imaging agent for vesicular monoamine transporter 2, Nuclear Medicine and Biology, 37, 133-141 (2010)

D.R. Sagar, M.D. Jhaven, D. Richardson, R.A. Gray, E. De Lago, J. Fernandez-Ruiz, D.A. Barrett, D.A. Kendall, and V. Chapman, Endocannabinoid regulation of spinal nociceptive processing in a model of neuropathic pain, European Journal of Neuroscience, 31 (8), 1414-1422 (2010)

M.E. Bardgett, M. Points, J. Kleier, M. Blankensip, and M.S. Griffith, The H3 antagonist, ciproxifan, alleviages the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats, Neuropharmacology, 59, 492-502, (2010)

S. Trazzi, M. Steger, V.M. Mitrugno, R. Bartesaghi, and E. Ciani, CB1 Cannabinoid receptors increase neuronal precursor proliferation through AKT/Glycogen synthase kinase-3beta/beta-catenin signaling, J. Biol. Chem., 285, 10098-10109 (2010)

K. Mmich, D.P. Finn, E. Dowd, and A.M. Gorman, Inhibition by Anandamide of 6-hydroxydopamine-induced cell death in PC12 cells, International Journal of Cell Biology, Article ID 818497, 10 pages (2010)

D. Feifel, J. Goldenberg, G. Melendez and P.D. Shilling, The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperature, Neuropharmacology, 58, 195-198 (2010)

C. Norman, S. Grimond-Billa, G. Bennett and H. Cassaday, A neurotensin agonist and antagonist decrease and increase activity, respectively, but do not preclude discrete cue conditioning, J. Psychopharmacology, 24 (3), 373-381 (2010)

A.N. Madsen, J. Jelsing, E.H.E.M van de Wall, N. Vrang, P.J. Larsen and G.J. Schwartz, Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents, Neuroscience Letters, 449, 20-23 (2009)

M.B. Gopinathan and K.S. Rehder, An Improved synthesis of (4-{4-hydroxy-3-isopropyl-5-[(4-nitrophenyl)ethynyl]benzyl}-3,5-dimethylphenoxy)acetic acid (NH-3), Synthesis, No. 9, 1428-1430 (2009)

L. S. Brady, L. Winsky, W. Goodman, M. E. Oliveri, and E. Stover, NIMH Initiatives to Facilitate Collaborations Among Industry, Academia, and Government for the Discovery and Clinical Testing of Novel Models and Drugs for Psychiatric Disorders, Neuropsychopharmacology Reviews, 34, 229-243 (2009).

Y. Sasaki, B.P.S. Vohra, F. E. Lund, and J. Milbrandt, Nicotinamide Mononucleotide adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide, The Journal of Neuroscience, 29(17), 5525-5535 (2009)

M. B. Gopinathan, C. Jin, and K. S. Rehder, A Short and Efficient Synthesis of 3-{2-[2-(Bromomethyl)thiazol-4-yl]ethynyl}-5-fluorobenzonitrile: A Precursor for PET Radioligand [18F]SP203, Synthesis, 12, 1979-1982 (2009)

S.C. Azad, J. Kurz, G. Marsicano, B. Lutz, W. Zieglgansberger, and G. Rammes, Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala, Learning & Memory, 15, 143-152 (2009)

D. Feifel, S. Mexal, G. Melendez, P.Y.T. Liu, J.R. Goldenberg, and P.D. Shilling, The Brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and A neurotensin analog, Neuropsychopharmacology, 34, 2011-2018 (2009)

T. Sun, G. Hu and L. Ming, Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibiton on amphetamine-induced hyperlocomotion: Relevance to animal models of antipsychotic drugs, Eur. J. Pharmacology, 602, 334-342 (2009)

P. Lafenetre, F. Chaouloff and G. Marsicano, Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system, Neuropharmacology, 57, 715-721 (2009)

Y. Arakane, J. Lomakin, R. W. Beeman, S. Muthukrishnan, S. H. Gehrke, M. R. Kanost and K. J. Kramer Molecular and functional analyses of amino acid decarboxylases involved in cuticle tannng in Tribolium castaneum J. Biol. Chem. 284 (24), 16584-16594 (2009)

J.L. Wiley and R. L. Evans, To breed or not to breed? Empirical evaluation of drug effects in adolescent rats, Int. J. Devl. Neuroscience, 27, 9-20 (2009)

S. Di, M.M. Maxson, A. Franco and J.G. Tasker, Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways, The Journal of Neuroscience, 29 (2), 393-401 (2009)

M. Li, W. He and A. Mead, Olanzapine and risperidone disrupt conditioned avoidance responding in phencyclidine-pretreated or amphetamine-pretreated rats by selectively weakening motivational salience of conditioned stimulus, Behavioural Pharmacology, 20 (1), 84-98 (2009)

C.J. Sun, S. Srivastva, J.R. Reifert and J.H. Waite, Halogenated DOPA in a marine adhesive protein, The Journal of Adhesion, 85 (2 & 3), 126-138 (2009)

R.K. McNamara, J. Able, R. Jandacek, T. Rider, P. Tso and D.M. Lindquist, Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo 1H-MRS study, Journal of Lipid Research, 50, 405-411 (2009)

Y. Kim, B. Hechler, Z.G. Gao, C. Gachet, and K.A. Jocobson, PEGylated Dendritic Unimolecular Micelles as Versatile Carriers for Ligands of G Protein-Coupled Receptors, Bioconjugate Chemistry, 20, 1888-1898 (2009)

D.C. Chiara, A.K. Hamouda, M.R. Ziebell, L.A. Mejia, G. Garcia III, and J.B. Cohen, [3H]Chlorpromazine Photolabeling of the Torpedo Nicotinic Acetylchloline Receptor Identifies Two State-Dependent Binding Sies in the Ion Channel, Biochemistry, 48 (42), 10066-10077 (2009)

M. Dvir-Ginzberg, V. Gagarina, E.-J. Lee and D.J. Hall, Regulation o cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyl transferase J. Biol. Chem., 283 (52), 36300-36310 (2008)

J. L. Wiley Antipsychotic-induced suppression of locomotion in juvenile, adolescent and adult rats, European Journal of Pharmacology, 578, 216-221 (2008)

C. Rabin, Y. Liang, R.S. Ehrlichman, A. Budhian, K.L. Metzger, C. Majewski-Tiedeken, K.I. Winey and S.J. Siegel, In vitro and in vivo demonstration of risperidone implants in mice, Schizophrenia Research, 98, 66-78 (2008)

S.C. Azad, J. Kurz and G. Marsicano, et al. Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala, Learn. Mem., 15, 143-152 (2008)

J.L. Wiley, S. H. Kendler, J. J. Burston, D. R. Howard and D. E. Selley Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats, Neuropharmacology, 55, 1183-1190 (2008)

A. Mead, M. Li and S. Kapur, Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: Contrast with haloperidol and chlordiazepoxide, Pharmacology, Biochemistry and Behavior, 90, 551-562 (2008)

B. Sunyer, S. Patil, C. Frischer, H. Hoeger and G. Lubee Strain-dependent effects of cognitive enhancers in the mouse, Amino Acids, 34, 485-495 (2008)

F. Brand, A.M. Klutz, K.A. Jacobson, B.B. Fredholm and G. Schulte, Adenosine A2a receptor dynamics studied with the novel fluorescent agonist Akexa488-APEC, European Journal of Pharmacology, 590, 36-42 (2008)

J.L. Wiley and R.L. Evans, Evaluation of age and sex differences in locomotion and catalepsy during repeated administration of haloperidol and clozapine in adolescent and adult rats, Pharmacological Research, 58, 240-246 (2008)

F.A. Moreira, N. Kaiser, K. Monory and B. Lutz, Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors, Neuropharmacology, 54, 141-150 (2008)

W.A. Fogel, A. Stasiak, A. Lewinski, M. Maksymowicz and J. Jochem, Satiety signalling histaminergic system and brain-gut peptides in regulation of food intake in rats with portocaval anastomosis, J. Physiol. Pharmacol., 59, Suppl 2, 135-144 (2008)

P.D. Shilling and D. Feifel, The neurotensin-1 receptor agonist PD149163 blocks fear-potentiated startle, Pharmacology, Biochemistry and Behavior, 90, 748-752 (2008)

L. Tedesco, A. Valerio, C. Cervino, A. Cardile, C. Pagano, R. Vettor, R. Pasquali, M.O. Carruba, G. Marsicano, B. Lutz, U. Pagotto and E. Nisoli, Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through eNOS expression in white adipocytes, Diabetes, 57, 2028-2036, (2008)

D. Feifel, G. Melendez, R.J. Murray, D.N.T. Tran, M.A. Rullan and P.D. Shilling The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit tolerance, Psychopharmacology, 200, 197-203 (2008)

J. Zhang and C. Chen, Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation, The Journal of Biological Chemistry, 283 (33), 22601-22611 (2008)

S.K. Grimond-Billa, C. Norman, G.W.B, and H.J. Cassaday, Selectively increased trace conditioning under the neurotensin agonist PD 149163 in an aversive procedure in which SR 142948A was without intrinsic effect, Psychopharmacol., 22 (3), 290-299 (2008)

K.G. Boldt, G.A. Brine and K. Rehder, Synthesis of (+)-9-O-Desmethyl-a-dihydrotetrabenazine, precursor for the high affinity VMAT2 imaging pet radioligand (11c)-(+)-a-dihydrotetrabenazine, Organic Preparations and Procedures International, 40 (4), 379-384 (2008).

C. Jin, L. D. Mayer, A. H. Lewin, K. S. Rehder and G. A. Brine, Practical Synthesis of p-aminophen-ethyl-spiperone (NAPS), a High -Affinity, Selective D2-dopamine Receptor Antagonist, Synth. Commun., 38 (5), 816-823 (2008).

G. Manikumar, C. Jin and K. S. Rehder, Convenient Synthesis of Tolcapone, a Selective Catechol-O-methyltransferase Inhibitor, Synth. Commun., 38 (5), 810-815 (2008).

G. Roussy, M.-A. Dansereau, L. Dore-Savard, K. Belleville, N. Beaudet, E. Richelson and P. Sarret, Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model, Journal of Neurochemistry, 105 (4), 1100-1114 (2008).

H. Yang, J. Zhang, R.M. Breyer, C. Chen, Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor, Journal of Neurochemistry, 108: 295-304 (2008).

H. Yang, J. Zhang, K. Andreasson, C. Chen, COX-2 oxidative metabolism of endocannabinoids augments hippocampal synaptic plasticity, Mol. Cell Neurosci. 37:682-695 (2008).

N. Sang, J. Zhang, C. Chen, COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity, J. Neurochem. 102:1966-1977 (2007).

D. Feifel, G. Melendez, K. Priebe, P.D. Shilling, The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats. Behav Brain Res. 181(2):278-86 (2007).

W. Ni, G.D. Fink, S.W. Watts, The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. May;321(2):485-91 (2007).

D. Wirtshafter, Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822, Pharmacol., Biochem. and Behav., 86, 505–510 (2007).

M. R. Kilbourn, Brian Hockley, Lihsueh Lee, Catherine Hou, Rjech Goswami, D. E. Ponde, M.-P. Kung and H. F. Kung, Pharmacokinetics of [18F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain, Nuclear Medicine and Biology, 34, 233-237 (2007).

I. J. Lever, T. M. Pheby and A. S. C Rice, Continuous infusion of the cannabinoid WIN 55,212-2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity, British Journal of Pharmacology, 151, 292-302 (2007).

W. M. Caudle, J. R. Richardson, M. Z. Wang, T. N. Taylor, T. S. Guillot, A. L. McCormack, R. E. Colebrooke, D. A. DiMone, P. C. Emson and G. W. Miller, Reduced Vesicular Storage of Dopamine Causes Progressive Nigrostriatal Neurodegeneration, The Journal of Neuroscience, 27 (30), 8138-8148 (2007).

L. Zhao, C. Jin, Z. Mao, M. B. Gopinathan, K. Rehder and R. D. Brinton, Design, Synthesis, and Estrogenic Activity of a Novel Estrogen Receptor Modulator–A Hybrid Structure of 17beta-Estradio and Vitamin E in Hippocampal Neurons, J. Med. Chem., 50, 4471-4481 (2007).

C. Jin, K. G. Boldt, K. S. Rehder, and G. A. Brine, Improved Syntheses of N-Desmethylcitalopram and N,N-Didesmethylcitalopram, Synth. Commun., 37 (6), 901-908 (2007).

Jaime M. Hatcher, Jason R. Richardson, Thomas S. Guillot, Alison L. McCormack, Donato A. DiMonte, Dean P. Jones, Kurt D. Pennell and Gary W. Miller, Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system, Experimental Neurology, 204, 619-630 (2007).

D. Feifel. Method of inhibiting neural transmission mediated by serotonin-2a and enhancing sensorimotor gating, U.S. Patent Application 20060179492, (2006).

Xiaohua Li, Kelley M. Rosborough, Ari B. Friedman, Wawa Zhu and Kevin A. Roth, Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics, The International Journal of Neuropsychopharmacology, Cambridge Univ. Press, (2006).

R. K. McNamara, B. Levant, B. Taylor, R. Ahlbrand, Y. Liu, J. R. Sullivan, K. Stanford, and N. M. Richtand, C57BL/6J Mice exhibit reduced Dopamine D3 receptor-mediated locomotor-inhibitory function relative to DBA/2J mice, Neuroscience, 143 (1), 141-153 (2006).

C. Jin, J. P. Burgess, K. S. Rehder and G. A. Brine, Synthesis of N6-[endo-2'-(endo-5'-Hydroxy)norbornyl]-8-(N-methylisopropylamino)-9-methyladenine (WRC-0571): A potent and selective adenosine A1 receptor antagonist, Synthesis, (2), 219-224 (2007).

Leah N. Squires, Jennifer A. Jakubowski, Jeffrey N. Stuart, Stanislav S. Rubakhin, Nathan G. Hatcher, Won-Suk Kim, Kevin Chen, Jean C. Shih, Isabelle Seif and Jonathan V. Sweedler, Serotonin Catabolism and the Formation and Fate of 5-Hydroxyindole Thiazolidine Carboxylic Acid The Journal of Biological Chemistry, 281 (19), 13463-13470 (2006).

Yolanda Zea-Ponce, Ronald M. Baldwin, Richard A. Miliust, Venkatesalu Bakthavachalam and Robert B. Innis, [123I]iodomethane, a main product in the synthesis of 5-[123I]iodo-6-nitroquipazine by iododestannylation, Journal of Labelled Compounds and Radiopharmaceuticals, 36 (4), 331-337 (2006).

Chunyang Jin, Jason P. Burgess, Madathil B. Gopinathan and George A. Brine, Chemical synthesis and structural elucidation of a new serotonin metabolite: (4R)-2-[(5'-hydroxy-1'H-indol-3'-yl)methyl]thiazolidine-4-carboxylic acid, Tetrahedron Letters, 47, 943-946 (2006).

Rajesh Goswami, Dattaq E. Ponde, Mei-Ping Kung, Catherine Hou, Mike R. Kilbourn, Hank F. Kung, Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters, Science Direct, 33, 685-694, (2006).

N. Sang, J. Zhang, C. Chen, PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons, J. Physiol. (Lond), 572: 735-745 (2006).

J.P. Chhatwal, M. Davis, K.A. Maguschak, K.J. Ressler, Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear, Neuropsychopharmacology, 30(3), 516-524 (2005), doi:10.1038/sj.npp.1300655.

Matthew L. MacDonald, Molly E. Eaton, Joshua T. Dudman and Christine Konradi, Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat, Biol. Psychiatry, 57 (9), 1041-1051 (2005).

Paula R. Powell, Tracy L. Paxon, Kyung-An Han and Andrew G. Ewing, Analysis of biogenic amine variability among individual fly heads with micellar electrokinetic capillary chromatography-electrochemical detection, Anal Chem., 77 (21), 6902-6908 (2005).

Tracy L. Paxon, Paula R. Powell, Hyun-Gwan Lee, Kyung-An Han and Andrew G. Ewing, Microcolumn Separation of Amine Metabolites in the Fruit Fly, Anal Chem., 77 (16), 5349-5355 (2005).

Sandra Panchalingam and Ashiwel S. Undie, Physicochemical modulation of agonist-induced [35S]GTPyS Binding: Implications for Coexistence of Multiple Functional Conformatios of Dopamine D1-like Receptors, Journal of Receptors and Signal Transduction, 25 (2), 125-146 (2005).

Klaus Becker, Matthias Eder, Walter Zieglgansberger, Hans-Ulrich Dodt, WIN 55,212-2 Decreases the spatial spread of neocortical excitation in vitro, NeuroReport, 16 (9), 993-996 (2005).

T. J. Price, A. M. Patwardhan, C. M. Flores and K. M. Hargreaves, A Role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons, Neuropharmacology, 49 (1), 25-39 (2005).

Katsura Nozawa; et al., Novel potassium-dependent sodium-calcium exchanger, U.S. Patent Application 20050119173, (2005).

Gerard J. O'Sullivan, Anthony Kinsella, David R. Sibley, Orna Tighe, David T. Croke and John L. Waddington, Ethological resolution of behavioural topography and D1-like versus D2-like agonist responses in congenic D5 dopamine receptor mutants: Identification of D5:D2-like interactions, Synapse, 55 (4), 202-211 (2005).

M. Panjehpour, M. Castro and K. -N. Klotz, Human breast cancer cell line MDA-MB-231 expresses endogenous A 2B adenosine receptors mediating a Ca 2+ signal, British Journal of Pharmacology, 145 (2), 211-218 (2005).

D. Wirtshafter, C.V. Osborn, The atypical dopamine D1 receptor agonist SKF 83959 induces striatal Fos expression in rats, Eur. J. Pharmacol., 528, 88–94 (2005).

W. Ni, C.S. Wilhelm, M. Bader, D.L. Murphy, K. Lookingland, S.W. Watts, (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter. J. Pharmacol. Exp. Ther. Sep;314(3):953-60 (2005).

W. Ni, M.W. Li, K. Thakali, G.D. Fink, S.W. Watts, The fenfluramine metabolite (+)-norfenfluramine is vasoactive. J. Pharmacol. Exp. Ther. May;309(2):845-52 (2004).

T. J. Price, A. Patwardhan, A. N. Akopian and K. M. Hargreaves, Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists, British Journal of Pharmacology, 141, 1118-1130 (2004).

Peter S. Talbot, W. Godon Frankie, Dah-Ren Hwang, Yiyun Huang, Raymond F. Suckow, Mark Slifstein, Anissa Abi-Dargham and Marc Laruelle, Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans, Synapse, 55 (3), 164-175 (2004).

D. P. Finn, S. R. G. Beckett, D. Richardson, D. A. Kendall, C. A. Marsden and V. Chapman, Evidence for differential modulation of coniditioned aversion and fear-conditioned analgesia by CB1 receptors, European Journal of Neuroscience, 20 (3), 848-852 (2004).

Kimberly A. Petrie, Michael Bubser, Cheryl D. Casey, M. Duff Davis, Bryan L. Roth and Ariel Y. Deutch, The Neurotensin Agonist PD14913 Increases Fos Expression in the Prefrontal Cortex of the Rat, Neuropsychopharmacology, 29, 1878-1888 (2004).

P. D. Shilling, G. Melendez, K. Priebe, E. Richelson and D. Feifel, Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT 2A and an a1 agonist, Psychopharmacology, 175 (3), 353-359 (2004).

P. Alexander Arguello and J. David Jentsch, Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat, Psychopharmacology, 177 (1-2), 141-150 (2004).

Yasuyuki Makihara, Hiroshi Yamamoto, Mai Inoue, Katsunori Tomiyama, Noriaki Koshikawa and John L. Waddington, Topographical effects of D1-like dopamine receptor agonistson orofacial movements in mice and their differential regulation via oppositional versus synergistic D1-like: D2-like interactions: cautionary observations on SK&F 82958 as an anomalous agent, Journal of Psychopharmacology, 18 (4), 484-495 (2004).

M. Soaje and R. P. Deis, Involvement of Opioid Receptor Subtypes in Both Stimulatory and Inhibitory Effects of the Opioid Peptides on Prolactin Secretion During Pregnancy, Biomedical and Life Sciences, 24 (2), 193-204 (2004).

David Feifel, Gilia Melendez and Paul D. Shilling, Reversal of Sensorimotor Gating Deficits in Brattleboro Rats by Acute Administration of Clozapine and a Neurotensin Agonist, but not Haloperidol: a Potential predictive model for novel antipsychotic effects, Neuropsychopharmacology, 29, 731-738 (2004).

Theodore J. Price, Amol Patwardhan, Armen N. Akopian, Kenneth M. Hargreaves and Christopher M. Flores Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons, British Journal of Pharmacology, 142, 257-266 (2004).

Jennifer Ronesi, Gregory L. Gerdeman and David M. Lovinger, Disruption of Endocannabinoid Release and Striatal Long-Term Depression by Postsynaptic Blockage of Endocannabinoid Membrane Transport, J. Neurosci., 24 (7), 1673-1679 (2004).

Z. Cao, S. Hallur, H. Z. Qiu, X. Peng and Y. Li, Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicity, Biochem. Biophys. Res. Comm., 316, 1043-1049 (2004).

G. J. O'Sullivan, B. L. Roth, A. Kinsella and J. L. Waddington, SF&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography, Eur. J. Pharmacol., 486, 273-280 (2004).

Margaret I. Davis, Jennifer Ronesi and David M. Lovinger, A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells, J. Biol. Chem., 278 (49), 48973-48980 (2003).

Barbara J. Ebersole, Irache Visiers, Harel Weinstein and Stuart C. Sealfon Molecular Basis of Partial Agonism: Orientation of Indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy, Molecular Pharmacology, 63, (1), 36-43 (2003).

Katsunori Tomiyama, Fergal N. McNamara, Jeremiah H. Clifford, Anthony Kinsella, John Drago, Sara Fuchs, David K. Grandy, Malcolm J. Low, Marcelo Rubinstein, Orna Tighe, David T. Croke, Noriaki Koshikawa and John L. Waddington, Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout", Synapse, 51 (1), 71-81 (2003).

Shahnaz Christina Azad, Matthias Eder, Giovanni Marsicano, Beat Lutz, Walter Zieglgansberger and Gerhard Rammes, Activation of the Cannabinoid Receptor Type 1 Decreases Glutamatergic and GABAergic Synaptic Transmission in the Lateral Amygdala of the Mouse, Learning & Memory, 10l, 116-128 (2003).

R. J. Rodgers, J. Haller, J. Halasz and E. Mikics, 'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevatec plus-maze, European Journal of Neuroscience, 17 (6), 1279-1286 (2003).

Daniela Cota, Giovanni Marsicano, Matthias Tschop, Yvonne Grubler, Cornelia Flachskamm, Mirjam Schubert, Dorothee Auer, Alexander Yassouridis, Christa Thone-Reineke, et. al..., The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis, J. Clinical Investigation, 112, 423-431 (2003).

Christopher D. Verrico, J. David Jentsch, Laura Dazzi and Robert H. Roth, Systemic, but not local, administration of cannabinoid CB1 receptor agonists modulate prefrontal cortical acetylcholine efflux in the rat, Synapse, 48 (4), 178-183 (2003).

K. Tomiyama, F. N. McNamara, J. J. Clifford, A. Kinsella, J. Drago, O. Tighe, D. T. Croke, N. Koshikawa and J. L. Waddington, Phenotypic resolution of spontaneous and D (1)-like agonist-induced orofacial movement topographies in congenic dopamine D receptor ..., Neuropharmacology, 42, 644-652 (2002).

M. Soaje, EG de Di Nasso and R. P. Deis, Regulation by endogenous opioids of suckling-induced prolactin secretion in pregnant and lactating rats: role of ovarian steroids, Journal of Endocrinology, 172 (2), 255-261 (2002).

Giovanni Marsicano, Carsten T. Wotjak, Shahnaz C. Azad, Tiziana Bisogno, Gerhard Rammes, Maria Grazia Cascio, Heike Hermann, Jianrong Tang, Clementine Hofmann, et. al., The endogenous cannabinoid system controls extinction of aversive memories, Nature, 418, 530-534 (2002).

Gregory L. Gerdeman, Jennifer Ronesi and David M. Lovinger, Postsynaptic endocannabinoid release is critical to long-term depression in the striatum, Nature Neuroscience, 5, 446-451 (2002).

Fergal N. McNamara, Jeremiah J. Clifford, Orna Tighe, Anthony Kinsella, John Drago, Sara Fuchs, David T. Croke and John L. Waddington, Phenotypic, ethologically based resolution of spontaneous and D2-like vs. D1-like agonist-induced behavioural topography in mice with congenic D3 dopamine receptor "knockout", Synapse, 46 (1), 19-31 (2002).

Carol A. Tamminga, Charles B. Nemeroff, Randy D. Blakely, Linda Brady, Cameron S. Carter, Kenneth L. Davis, Raymond Dingledine, Jack M. Gorman, Dimitri E. Grigoriadis, et. al., Developing Novel Treatments for Mood Disorders: Accelerating Discovery, Biol. Psychiatry, 52 (6), 589-609 (2002).

Gregory L. Gerdeman, Jennifer Ronesi and David M. Lovinger, Postsynaptic endocannabinoid release is critical to long-term depression in the striatum, Nature Neuroscience, 5 (5), 446-451 (2002).

T. J. DeVries, Y. Shaham, J. R. Homberg, H. Crombag, K. Schurman, J. Dieben, L.J.M.J. Vanderschuren, and A.N.M. Schoffelmeer A cannabinoid mechanism in relapse to cocaine seeking Nature Med 7, 1151 (2001).

S. Panchalingam and A. S. Undie, SKF83959 exhibits biochemical agonism by stimulating [ S]GTP ?S binding and phosphoinositide hydrolysis in rat and monkey brain, Neuropharmacology, 40, 826-837 (2001).

A. K. Patni, S. Gupta, A. Sharma, A. K. Tiwary, and S. K. Garg Role of intracellular calcium in the spermicidal action of 2',4'-dichlorobenzamil, a novel contract spermicide, J. Pharm. Pharmacol. 53, 1387-1392 (2001).

P. R. Reddy, A. Patni, A. Sharma, S. Gupta, and A. K. Tiwary Effect of 2',4'-dichlorobenzamil hydrochloride, a Na +-Ca 2+ exchange inhibitor, on human spermatozoa Eur. J. Pharmacol. 418, 153-155 (2001).

N. Safran, V. Shneyvays, N. Balas, K. A. Jacobson, H. Nawarth, and A. Shainberg Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes Mol. Cell. Biochem 217, 143-152 (2001).

V. Shneyvays, L. Mamedova, T. Zinman, K. Jacobson, and A. Shainberg Activation of A 3adenosine receptor protects against doxorubicin-induced cardiotoxicity J. Mol. Cell Cardiol 33, 1249-1261 (2001).

D. Bridges, K. Ahman and A. S.C. Rice, The Synthetic Cannabinoid WIN55, 212-2 attenuates hyperalgesia and allodynia in a rat model of ...., British Journal of Pharmacology, 133, 586-594 (2001).

Gregory Gerdeman and David M. Lovinger, CB1 Cannabinoid Receptor Inhibits Synaptic Release of Glutamate in Rat Dorsolateral Striatum, Journal of Neurophysiology, 85 (1), 468-471 (2001).

T. Obsil, R. Ghirlando, D. Klein, S. Ganguly and F. Dyda, Crystal Structure of the 14-3-3?: Serotonin N-acetyltransferase Complex A role for scaffolding in enzyme regulation, Cell, 105 (2), 257-267 (2001).

I. A. Antonijevic, J. A. Russell, R. J. Bicknell, G. Leng and A. J. Douglas, Effect of progesterone on the activation of neurones of the supraoptic nucleis during parturition, Journal of Reproduction and Fertility, 120, 367-376 (2000).

F. Dyda, D. C. Klein, and A. B. Hickman. GCN5-related N-acetyltransferases: A structural overview. Annu. Rev. Biophys. Biomol. Struct. 29, 81-103 (2000).

S. W. Rhee and M. J. Tanga Synthesis of tritium labelled 4P-PDOT, a selective melatonin receptor antagonist J. Labelled Cpd. Radiopharm 43, 925-932 (2000)

V. Shneyvays, K. A. Jacobson, A.-H. Li, H. Nawrath, T. Zinman, A. Issac, and A. Shainberg Induction of apoptosis in rat cardiocytes by A3 adenosine receptor activation and its suppression by isoproterenol Exp. Cell Res 257, 111-126 (2000).

T. V. Dunwiddie, K. A. Jacobson, and L. Diao. An adenosine A 3receptor-selective agonist does not modulate calcium-activated potassium currents in hippocampal CA1 pyramidal neurons. Progr. Brain Res. 120, 275-285 (P. Illes and H. Zimmermann, Eds.), (1999).

A. B. Hickman, M. A. A. Namboodiri, D. C. Klein and F. Dyda, The structural basis of ordered substrate binding by serotonin N-acetyltransferase: Enzyme complex at 1.8 Angstrom resolution with a bisubstrate analog, Cell, 97, 361-369 (1999).

W. Xu, S. Leung, J. Wright and S. E. Guggino, Expression of Cyclic Nucleotide-Gated Cation Channels in Airway Epithelial Cells, Journal of Membrane Biology, 171 (2), 117-126 (1999).

K.-N. Klotz, E. Camaioni, R. Volpini, S. Kachler, S. Vittori and G. Cristalli, 2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors, Naunyn-Schmiedeberg's Archives of Pharmacology, 360 (2), 103-108 (1999).

W. J. Murdoch, Perturbation of Sheep Ovarian Surface Epithelial Cells by Ovulation: Evidence for roles of progesterone and poly(ADP-ribose) polymerase in the restoration of DNA integrity, Journal of Endocrinology, 156 (3), 503-508 (1998).

David Fulton and John Quilley Evidence against Anandamide as the Hyperpolarizing Factor Mediating the Nitric Oxide-Independent Coronary Vasodilator Effect of Bradykinin in the Rat, J. Pharmacology and Experimental Therapeutics, 286 (3), 1146-1151 (1998).

M. Soaje and R. P. Deis, Opioidergic Regulation of Prolactin Secretion During Pregnancy: role of ovarian hormones, Journal of Endocrinology, 155 (1), 99-106 (1997).

David R. Wallace, Charles F. Mactutus and Rosemarie M. Booze, Repeated Intravenous cocaine administration: Locomotor activity and dopamine D2/D3 receptors, Synapse, 23 (3), 152-163 (1996).

Steven D. Wyrick, Raymond G. Booth, Andrew M. Myers, Constance E. Owens, Ehren C. Bucholtz, Phillip C. Hooper, Nora S. Kula, Ross J. Baldessarini and Richard B. Mailman, 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes and related derivatives as ligands for the neuromodulatory s3 receptor: Further structure-activity relationships, J. Med. Chem., 38, 3857-3864 (1995).

J. Eric Ahiskog, Ryan J. Uitti, Phillip A. Low, Gertrude M. Tyce, Kim K. Nickander, Ronald C. Petersen and Emre Kokmen, No evidence for systemic oxidant stress in Parkinson's or alzheimer's disease, Movement Disorders, 10 (5), 566-573 (1995).

Brian Duff Sloley, y-Glutamyl conjugation of 5-hydroxytryptamine (serotonin) in the earthworm (Lumbricus terrestris), Neurochemical Research, 19 (2), 217-222 (1994).

Nora S. Kula, Ross J. Baldessarini, John W. Kebabian and John L. Neumeyer, S-(+)-aporphines are not selective for human D3 dopamine receptors, Cellular and Molecular Neurobiology, 14 (2), 185-191 (1994).

P. S. Puttfarcken, J. S. Handen, D. T. Montgomery, J. T. Coyle and L. L. Werling, N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices, Journal of Pharmacology and Experimental Therapeutics, 266 (2), 796-803 (1993).

Thomas A. Cawley Jr. and Timothy J. Shickley, The Potential Neurotoxin 2-OH-Dopamine is an Inhibitor of Arylsulfatase, Annals of the New York Academy of Sciences, 648 (1), 256-259 (1992).

B.-A. Battelle, S. C. Edwards, L. Kass, H. M. Maresch, S. K. Pierce and A. C. Wishart, Identification and Function of Octopamine and Tyramine Conjugates in the Limulus Visual System, Journal of Neurochemistry, 51 (4), 1240-1251 (1988).

About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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