NIMH Chemical Synthesis and Drug Supply Program


The NIMH is eager to be apprised of publications resulting from use of the Chemical Synthesis and Drug Supply Program (CSDSP)compounds it has supplied. In light of budgetary restrictions, The CSDSP frequently needs to justify its existence. If you find its service useful, please keep the CSDSP informed of your published results (see contacts).

In addition, please indicate in the Materials & Methods section of your publication that the compounds were obtained from the NIMH Chemical Synthesis and Drug Supply Program. If you are aware of key references about CSDSP compounds, please contact the CSDSP and the references will be added to the compound information page.

NIMH CSDSP referencing publications:

J.B. Dwyer, F.M. Leslie, Adolescent maturation of dopamine D1 and D2 receptor function and interactions in rodents, PloS one, 11(1) (2016).

Y. Cheng, M. Pardo, S. Armini, A. Martinez, H. Mouhsine, J.-F. Zagury, R.S. Jope, E. Beurel, Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior, Brain, Behavior, and Immunity (2016).

M. Zhang, M. Li, Behavioral and pharmacological validation of an integrated fear-potentiated startle and prepulse inhibition paradigm, Behavioural Brain Res., 307, 176-185 (2016).

D. Wirtshafter, T.R. Stratford, Chemogenetic inhibition of cells in the paramedian midbrain tegmentum increases locomotor activity in rats, Brain Res., 1632, 98-106 (2016).

B.A. Davis, A. Nagarajan, L.R. Forrest, S.K. Singh, Mechanism of paroxetine (Paxil) inhibition of the serotonin transporter, Scientific Reports, 6 (2016).

A. Manduca, M. Servadio, R. Damsteegt, P. Campolongo, L.J.M.J. Vanderschuren, V. Trezza, Dopaminergic neurotransmission in the nucleus accumbens modulates social play behavior in rats, Neuropsychopharmacology, (2016).

M. Malik, C. Rangel-Barajas, R.H. Mach, R.R. Luedtke, The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice, Pharmacol. Biochem. & Behav., 148, 136-144 (2016).

A. Manduca, M. Morena, P. Campolongo, M. Servadio, M. Palmery, L. Trabace, M.N. Hill, L.J.M.J. Vanderschuren, V. Cuomo, V. Trezza, Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats, Eur. Neuropsychopharmacol., doi:10.1016/j.euroneuro.2015. 04.005.

E. Pearlstein, F.J. Michel, R. Cloarec, C. Hammond, Glutamatergic synaptic currents of nigral dopaminergic neurons follow a postnatal developmental sequence, Frontiers in Cellular Neuroscience, 9, 210 (2015).

Gero D, Szabo C. Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post?hypoxic cardiomyocytes, British J. Pharmacol. 172(20):4817-32 (2015).

G.K. Ford, O. Moriarty, B.N. Okine, E. Tully, A. Mulcahy, B. Harhen, D.P. Finn, Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats, European J. of Pain, 19(8), 1177-1185 (2015).

P. Zanos, S.C. Piantadosi, H.-Q. Wu, H.J. Pribut, M.J. Dell, A. Can, H.R. Snodgrass, C.A. Zarate, R. Schwarcz, T.D. Gould, The prodrug 4-chlorokynurenine causes ketamine-like antidepressant effects, but not side effects, by NMDA/glycineB-site inhibition, J. Pharmacol. & Exp. Therap., 355(1), 76-85 (2015).

M. Morales, M.M. McGinnis, B.A. McCool, Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long–Evans rats, Pharmacol. Biochem. & Behav., 139, 67-76 (2015).

M.B. Pomrenze, E.Z. Millan, F.W. Hopf, R. Keiflin, R. Maiya, A. Blasio, J. Dadgar, V. Kharazia, G. De Guglielmo, E. Crawford, P.H. Janak, O. George, K.C. Rice, R.O. Messing, A transgenic rat for investigating the anatomy and function of corticotrophin releasing factor circuits, Frontiers in Neurosci., 9 (2015).

M.L. Berger, P. Rebernik, Differential influence of 7 cations on 16 non-competitive NMDA receptor blockers, Bioorg. & Med. Chem. Letts., 25(19), 4131-4135 (2015).

T. Scardochio, I. Trujillo-Pisanty, K. Conover, P. Shizgal, P.B.S. Clarke, The effects of electrical and optical stimulation of midbrain dopaminergic neurons on rat 50-kHz ultrasonic vocalizations, Frontiers in Behavioral Neurosci., 9 (2015).

L.E. Mueller, M.A. Kausch, T. Markovic, D.A.A. MacLaren, D.M. Dietz, J. Park, S.D. Clark, Intra-ventral tegmental area microinjections of urotensin II modulate the effects of cocaine, Behavioural Brain Res., 278, 271-279 (2015).

P. Yang, L. Zhang, Q-J. Shi, Y-B. Lu, M. Wu, E-Q Wei, W-P. Zhang, Nicotinamide phosphoribosyltransferase inhibitor APO866 induces C6 glioblastoma cell death via autophagy, Die Pharmazie-An Internat. J. of Pharmac. Sci., 70(10), 650-655 (2015).

B.T. Burrows, L.R. Watterson, M.A. Johnson, M.F. Olive, Effects of modafinil and R-modafinil on brain stimulation reward thresholds: implications for their use in the treatment of psychostimulant dependence, Journal of Drug and Alcohol Research, 4 (2015), doi:10.4303/jdar/235958.

J.A. Brown, T.S. Ramikie, M.J. Schmidt, R. Báldi, K. Garbett, M.G. Everheart, L.E. Warren, L. Gellért, S. Horváth, S. Patel, K. Mirnics, Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes, Molecular Psychiatry, doi:10.1038/mp.2014.192 (2015).

Y. Qiu, Y. Zhang, J-X. Li, Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats, Eur. J. Pharmacol., 749, 133–141 (2015).

H.G.S. Martin, O. Lassalle, J.T. Brown, O.J. Manzoni, Age-dependent long-term potentiation deficits in the prefrontal cortex of the Fmr1 knockout mouse model of Fragile X Syndrome, Cereb. Cortex, doi: 10.1093/cercor/bhv031 (2015).

M.A. Gannon, C.J. Brown, R.M. Stevens, M.S. Griffith, C.A. Marczinski, M.E. Bardgett, Early-life risperidone administration alters maternal–offspring interactions and juvenile play fighting, Pharmacol. Biochem. Behavior, 130, 90–96 (2015).

Y. Kawasaki, T. Fujita, K. Yang, E. Kumamoto, Anandamide Depresses Glycinergic and GABAergic Inhibitory Transmissions in Adult Rat Substantia Gelatinosa Neurons. Pharmacol. & Pharm. 6(3), 103-117 (2015).

L.G. Chastain, H. Qu, C.H. Bourke, P.M. Luvone, P.R. Dobner, C.B. Nemeroff, B. Kinkead, Striatal dopamine receptor plasticity in neurotensin deficient mice, Behav. Brain Res., 280, 160-171 (2015).

J.W. Lovelace, A. Corches, P.A. Vieira, K. Mackie, E. Korzus, An animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity, Neuropharmacology, 99, 242-255 (2015).

M. Feng, J. Gao, N. Sui, M. Li, Effects of central activation of serotonin 5-HT2A/2C or dopamine D2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test, Psychopharmacol., 232, 1219-1230 (2015).

J. Gao, R. Qin, M. Li, Repeated administration of aripiprazole produces a sensitization effect in the suppression of avoidance responding and phencyclidine-induced hyperlocomotion and increases D2 receptor-mediated behavioral function, J. Psychopharmacol., 29(4), 390-400 (2015).

J.O-Y. Yau, G.P. McNally, Pharmacogenetic excitation of dorsomedial prefrontal cortex restores fear prediction error, J. Neurosci., 35(1), 74-83 (2015).

S. Ding, L. Li, F.M. Zhou, Robust presynaptic serotonin 5-HT1B receptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatment, J. Neurophysiology, 113(9), 3397-3409 (2015).

A. Maffei, A.M. Segal, J.C. Alvarez-Perez, A. Garcia-Ocaña, P.E. Harris, Anti-incretin, anti-proliferative action of dopamine on beta-cells, Molecular Endocrinology, 29(4), 542–557 (2015).

A. Cagnetta, D. Soncini, I. Caffa, C. Acharya, P. Acharya, S. Adamia, I. Pierri, M. Bergamaschi, A. Garuti, G. Fraternali-Orcioni, A. Provenzani, L. Mastracci, C. Zucal, G. Damonte, APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells. Clin. Cancer Res. 21(17), 3934-3945 (2015).

Y.E. Ogbonmwan, J.P. Schroeder, P.V. Holmes, D. Weinshenker, The effects of post-extinction exercise on cocaine-primed and stress-induced reinstatement of cocaine seeking in rats. Psychopharmacol. 232, 1395-1403 (2015).

J.B. Thomas, A.M. Giddings, S. Olepu, R.W. Wiethe, K.R. Warner, P. Sarret, J-M. Longpre, S.P. Runyon, B.P. Gilmour, The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2. Bioorg. Med. Chem. Lett. 25(10), 2060–2064 (2015).

J.B. Thomas, A.M. Giddings, S. Olepu, R.W. Wiethe, D.L. Harris, S. Narayanan, K.R. Warner, P. Sarret, J-M. Longpre, S.P. Runyon, B.P. Gilmour, Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Bioorg. Med. Chem. Lett. 25(2), 292–296 (2015).

M. Malik, C. Rangel-Barajas, N. Sumien, C. Su, M. Singh, Z. Chen, R-Q. Huang, J. Meunier, T. Maurice, R.H. Mach, R.R. Luedtke, The effects of sigma-1 receptor selective ligands on muscarinic receptor antagonist induced cognitive deficits in mice, Brit. J. Pharmacol., 172(10), 2519–2531 (2015).

Q. Shu, R. Qin, Y. Chen, G. Hu, M. Li, Asenapine sensitization from adolescence to adulthood and its potential molecular basis, Behav. Brain Res., 273, 166-176 (2014).

B.C. Shonesy, R.J. Bluett, T.S. Ramikie, R. Báldi, D.J. Hermanson, P.J. Kingsley, L.J. Marnett, D.G. Winder, R.J. Colbran, Sachin Patel, Genetic Disruption of 2-Arachidonoylglycerol Synthesis Reveals a Key Role for Endocannabinoid Signaling in Anxiety Modulation. Cell Reports, 9(5), 1644–1653 (2014).

J.S. Dileep Kumar, V. Arango, S. Kassir, J. Prabhakaran, V. Majo, N. Simpson, V. Johnson, M. Underwood, J. Mann, In vitro binding of [3H]CUMI-101, a HT1AR radioligand in Alzheimer’s disease. J. Nucl. Med. 55(1), 1819 (2014).

H.R. Modi, M. Basselin, S.I. Rapoport, Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4. Bipolar Disorders, 16(8), 875–880 (2014).

B. Riffault, I. Medina, C. Dumon, C. Thalman, N. Ferrand, P. Friedel, J-L. Gaiarsa, C. Porcher, Pro-Brain-Derived Neurotrophic Factor Inhibits GABAergic Neurotransmission by Activating Endocytosis and Repression of GABAA Receptors. J. Neurosci. 34(40):13516–13534 (2014).

D. Guimond, D. Diabira, C. Porcher, F. Bader, N. Ferrand, M. Zhu, S.M. Appleyard, G.A. Wayman, J-L. Gaiarsa, Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus, Frontiers Cell. Neurosci. 8(235):1-17 (2014).

H.G.S. Martin, O. Manzoni, Late onset deficits in synaptic plasticity in the valproic acid rat model of autism, Front. Cell. Neurosci., 8 (23), 1-8 (2014).

C.L. Pickens, F.R. Theberge; Blockade of CB1 receptors prevents retention of extinction but does not increase low preincubated conditioned fear in the fear incubation procedure, Behavioural Pharmacology, 2014, 25 (1), 23-31.

A.J. Prus, C.J. Schuck, K.R. Rusch, and L.M. Carey, The discriminative stimulus effects of the neurotensin NTS1 receptor agonist PD149163 in rats: stimulus generalization testing with dopamine D1 and D2 receptor ligands, Drug Dev. Res., 75 (2) 47-58 (2014).

J. Koci, L. Šimo, and Y. Park, Autocrine/paracrine dopamine in the salivary glands of the blackegged tick lxodes scapularis, J. Insect Physiology, 62, 39-45 (2014).

C. Rangel-Barajas, M. Malik, S. Vangveravong, R.H. Mach, and R.R. Luedtke, Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in make DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds, Neuropharmacology, 83, 18-27 (2014).

K. Rea, G.K. Ford, W.M. Olango, B. Harhen, M. Roche, and D.P. Finn, Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state, Eur, J. Neurosci., 39 (3) 435-443 (2014).

M.J. Duncan, K.M. Franklin, X. Peng, C. Yun, and S.J. Legan, Circadian rhythm disruption by a novel running wheel: Roles of exercise and arousal in blockade of the luteinizing hormone surge, Physiology & Behavior, 131, 7-16 (2014).

M.J. Duncan, K.M. Franklin, X. Peng, C. Yun, S.J. Legan, Circadian rhythm disruption by a novel running wheel: Roles of exercise and arousal in blockade of the luteinizing hormone surge, Physiol. & Behav., 131, 7-16 (2014).

D Soncini, I Caffa, G Zoppoli, M Cea, A Cagnetta, M Passalacqua, L Mastracci, S Boero, F Montecucco, G Sociali, D Lasigliè, P Damonte, A Grozio, E Mannino, A Poggi, V D'Agostino, F Monacelli, A Provenzani, P Odetti, A Ballestrero, S Bruzzone, A. Nencioni, Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity, J. Biological Chem., 289(49), 34189-34204 (2014).

A.E. Chávez, V.M. Hernández, A. Rodenas-Ruano, C.S. Chan, P.E. Castillo, Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus, J. Neurosci., 34(50), 16621-16629 (2014).

A. Manduca, M. Servadio, P. Campolongo, M. Palmery, L. Trabace, L.J.M.J. Vanderschuren, V. Cuomo, V. Trezza, Strain-and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats, Eur. Neuropsychopharmacol., 24(8), 1337–1348 (2014).

A.A. Keiser, K.S. Matazel, M.K. Esser, D. Feifel, A.J. Prus, Systemic administration of the neurotensin NTS?-receptor agonist PD149163 improves performance on a memory task in naturally deficient male Brown Norway rats, Exp. & Clin. Psychopharmacol., 22(6), 541 (2014).

R.J. Bluett, J.C. Gamble-George, D.J. Hermanson, N.D. Hartley, L.J. Marnett, S. Patel, Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. Transl. Psychiatry, 4, e408, doi:10.1038/tp.2014.53 (2014).

Y. Qiu, X.H. He, Y. Zhang, J.X. Li, Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats, Sci. Reports, 4, doi:10.1038/srep06605 (2014).

T.J. Donahue, T.M. Hillhouse, K.A. Webster, R. Young, E.O. De Oliveira, J.H. Porter, (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics, Eur. J. Pharm., 734, 15-22 (2014).

C. Rangel-Barajas, M. Malik, S. Vangveravong, R.H. Mach, R.R. Luedtke, Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds, Neuropharmacol., 83, 18-27 (2014).

T.J. Younts, V. Chevaleyre, P.E. Castillo, CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses. J. Neurosci. 33(34):13743-57 (2013).

L. Šimo, J. Koci, D. Kim, Y. Park; Invertebrate Specific D1-like Dopamine Receptor in Control of Salivary Glands in the Black-Legged Tick Ixodes scapularis, J. Comparative Neurol. Accepted: Dec 02, 2013, doi: 10.1002/cne.23515.

R. Qin, Y. Chen, M. Li; Repeated asenapine treatment produces a sensitization effect in two preclinical tests of antipsychotic activity, Neuropharmacology 2013, 75, 356–364.

S. Di, I.R. Popescu, J.G. Tasker; Glial control of endocannabinoid heterosynaptic modulation in hypothalamic magnocellular neuroendocrine cells, J. Neurosci, 2013, 33(46), 18331-18342.

M. Häring, M. Grieb, K. Monory, B. Lutz, F.A. Moreira, Cannabinoid CB1 receptor in the modulation of stress coping behavior in mice: the role of serotonin and different forebrain neuronal subpopulatins, Neuropharmacology, 65, 83-89 (2013)

M. Feng, N. Sui, M. Li, Environmental and behavioral controls of the expression of clozapine tolerance: evidence from a novel across-model transfer paradigm, Behav. Brain Res., 238, 178-187 (2013)

E.C. Berglund, N.J. Kuklinski, E. Karagündüz, K. Ucar, J. Hanrieder, A.G. Ewing, Freeze-drying as sample preparation for micellar electrokinetic capillary chromatography-electrochemical separations of neurochemicals in Drosophila brains, Anal. Chem., 85(5), 2841-2846 (2013)

H.R. Modi, A.Y. Taha, H.W. Kim, L. Chang, S.I. Rapoport, Y. Cheon, Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability, J. Neurochem., 124(3), 376-387 (2013)

J.S. Kumar, R.V. Parsey, S.A. Kassir, V.J. Majo, M.S. Milak, J. Prabhakaran, N.R. Simpson, M.D. Underwood, J.J. Mann, V. Arango, Autoradiographic evaluation of [3H]CUMI-101, a novel, selective 5-HT1AR ligand in human and baboon brain, Brain Res., 1507, 11-18 (2013)

H. Shen, H. Igarashi, N. Imamura, N. Matsuki, H. Nomura, N-methyl-D-aspartate receptors and protein synthesis are necessary for reinstatement of conditioned fear, Neuroreport., Jun 28 (2013)

A.R. Abela, S.D. Dougherty, E.D. Fagen, C.J. Hill, Y. Chudasama, Inhibitory control deficits in rats with ventral hippocampal lesions, Cereb. Cortex, 23(6), 1396-1409 (2013)

Z. Li, S.F. Schmidt, J.M. Friedman, Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth, Diabetes, 62(7), 2359-2367 (2013)

D.A. Stidd, K. Vogelsang, S.E. Krahl, J.P. Langevin, and J.M. Fellous, Amygdala deep brain stimulation is superior to paroxetine treatment in a rat model of posttraumatic stress disorder, Brain Stimul., Jun 25 (2013)

A. Salykin, P. Kuzmic, O. Kyrylenko, J. Musilova, Z. Glatz, P. Dvorak, and S. Kyrylenko, Nonlinear regression models for determination of nicotinamide adenine dinucleotide content in human embryonic stem cells, Stem Cell Rev., July 6 (2013)

A. Cagnetta, M. Cea, T. Calimeri, C. Acharya, M. Fulciniti, Y.T. Tai, T. Hideshima, D. Chauhan, M.Y. Zhong, F. Patrone, A. Nencioni, M. Gobbi, P. Richardson, N. Munshi, K.C. Anderson, Intracellular NAD+-depletion enhances bortezomib-induced anti-myeloma activity, Blood., 3(7) PMID:23823317 (2013)

I. Miederer, S. Maus, I. Zwiener, G. Podopryorina, D. Meschcheryakov, B. Lutz, M. Schreckenberger, Evaluation of cannabinoid type 1 receptor expression in the rat brain using [18F]MK-9470 micro PET, Eur. J. Nucl. Med. Mol. Imaging, July 9 (2013)

A. Grozio, G. Sociali, L. Sturla, I. Caffa, D. Soncini, A. Salis, N. Raffaelli, A. DeFlora, A. Nencioni, S. Bruzzone, CD73 as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells, J. Biol. Chem., doi:10.1074/jbc.M113.470435 (2013)

J. Hannestad, N. Dellagioia, J.D. Gallezot, K. Lim, N. Nabulsi, I. Esterlis, B. Pittman, J.Y. Lee, K.C. O’Connor, D. Pelletier, R.E. Carson, The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study, Brain Behav. Immun., doi:1016/j.bbi. (2013)

Q. Shu, G. Hu, M. Li, Is brain-derived neurotrophic factor a possible mechanism underlying risperidone sensitization in adolescent rats, Biochem. & Pharmacol., S1, doi:10.4172/2167-0501.S1-004 (2013)

D. Höfelmann, B. di Benedetto, S.C. Azad, V. Micale, C.T. Wotjak, G. Rammes, Lack of interaction of endocannabinoids and 5-HT3 neurotransmission in associative fear circuits of the amygdala: Evidence from electrophysiological and behavioural experiments, Brain Res., 1527, 47-56 (2013)

P. Singh, T.W. Fletcher, Y. Li, N.J. Rusch, F. Kilic, Serotonin uptake rates in platelets from angiotensin II-induced hypertensive mice, Health, 5(4A), 31-39 (2013)

R. Hovius, Characterization and Validation of Fluorescent Receptor Ligands: A Case Study of the Ionotropic Serotonin Receptor, Chemical Neurobiology, Humana Press, 2013, Chapter 12, 161-178.

M. Haddad, Do CB1 Cannabinoid Receptors Regulate Insulin Signalling in Rat Primary Skeletal Muscle Cells? J. Phys. Pharm. Adv. 2013, 3(12), 277-291.

A. Grozio, G. Sociali, L. Sturla, I. Caffa, D. Soncini, A. Salis, N. Raffaelli, A. De Flora, A. Nencioni, S. Bruzzone; CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells, J. Biolog. Chem. 2013, 288, 25938-25949.

B. Bosier, L. Bellocchio, M. Metna-Laurent, E. Soria-Gomez, I. Matias, E. Hebert-Chatelain, A. Cannich, M. Maitre, T. Leste-Lasserre, P. Cardinal, J. Mendizabal; Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes, Molecular Metabolism 2013, 2 (4), 393–404.

M. Magnone, I. Bauer, A. Poggi, E. Mannino, L. Sturla, M. Brini, E. Zocchi, A. De Flora, A. Nencioni*, S. Bruzzone*; NAD+ Levels Control Ca2+ Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes, J. Biol. Chem. 2012, 287, 21067-21081.

C. Cottingham, X. Li, Q. Wang, Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrentin3 and spinophilin, Neuropharmacology, 62(7), 2354-2362 (2012)

F.J. Meye, V. Trezza, L.J. Vanderschuren, G.M. Ramakers, R.A. Adan, Neutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity, Mol. Psychiatry, Oct. 16, diol: 10.1038/mp.2012.145 (2012)

M. Cea, A. Cagnetta, M. Fulciniti, Y.T. Tai, T. Hideshima, D. Chauhan, A. Roccaro, A. Sacco, T. Calimeri, F. Cottini, J. Jakubikova, S.Y. Kong, F. Patrone, A. Nencioni, M. Gobbi, P. Richardson, N. Munshi, K.C. Anderson, Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition, Blood, 120(17), 3519-3529 (2012)

C. He, X. Qu, J. Wan, R. Rong, L. Huang, C. Cai, K. Zhou, Y. Gu, S.Y. Qian, J.X. Kang, Inhibiting delta-6 desaturase activity suppresses tumor growth in mice, PLoS One, 7(10), e47567 (2012)

E. Beurel, M.A. Mines, L. Song, R.S. Jope, Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development, Bipolar Disord., 14(8), 822-830 (2012)

E.A. Stone, Y. Lin and Y. Sarfraz, Toward the Rapid Treatment of Depression by Selective Inhibition of Central Stress Circuits, The Open Neuropsychopharmacology Journal, 5, 9-17 (2012).

C. Zhang, M. Li; Contextual and behavioral control of antipsychotic sensitization induced by haloperidol and olanzapine, Behav Pharmacol. 2012, 23 (1), 66–79.

M. Li, W. He, R. Munro; Differential effects of acute amphetamine and phencyclidine treatment and withdrawal from repeated amphetamine or phencyclidine treatment on social interaction and social memory in rats, PsyCh Journal, 2012, 1 (1), 56–68.

J.Y. Xu, J. Zhang, C. Chen; Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids, J. Physiology, 2012, 590, 2305–2315.

K.A. Jacobson, Y. Kim, A. Klutz, B. Hechler, C. Gachet; Dendrimer conjugates of agonists and antagonists of the GPCR superfamily, US Patent 8,153,781 B2 (2012).

K.A. Jacobson, J. Jiang, Y. Kim, Y. Karton; Dihydropyrine-, Pyridine-, Benzopyran- One- and Triazoloquinazoline Derivative, Their Preparation and Their Use as Adenosine Receptor Antagonists, European Patent EP0885192 (2012).

A.L. Frederick, T.P. Saborido, G.D. Stanwood, Neurobehavioral phenotyping of G?q knockout mice reveals impairments in motor functions and spatial working memory without changes in anxiety or behavioral despair, Front. Behav. Neurosci., 6, 29-37 (2012)

N.M. Midde, A.M. Gomez, J. Zhu, HIV-1 Tat protein decreases dopamine transporter cell surface expression and vesicular monoamine transporter-2 function in rat striatal synaptosomes, J. Neuroimmune Pharmacol., 7(3), 629-639 (2012)

E. Ziu, C.P. Mercado, Y. Li, P. Singh, B.A. Ahmed, S. Freyaldenhoven, S. Lensing, J. Ware, F. Kilic, Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serontonin, J. Mol. Cell. Cardiol., 52, 1112-1121 (2012)

J. Hannestad, J-D. Gallezot, T. Schafbauer, K. Lim, T. Kloczynski, E.D. Morris, R.E. Carson, Y-S. Ding, K.P. Cosgrove, Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates, NeuroImage, 63, 232-239 (2012)

A.A. Williams, W.M. Ingram, S. Levine, J. Resnik, C.M. Kmel, J.R. Lish, D.I. Elizalde, S.A. Janowski, J. Shoker, A. Kozlenkov, J. Gonzalez-Maeso, A.L. Gallitano; Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine, Neuropsychopharmacol. 37, 2285-2298 (2012).

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Tracy L. Paxon, Paula R. Powell, Hyun-Gwan Lee, Kyung-An Han and Andrew G. Ewing, Microcolumn Separation of Amine Metabolites in the Fruit Fly, Anal Chem., 77 (16), 5349-5355 (2005).

Sandra Panchalingam and Ashiwel S. Undie, Physicochemical modulation of agonist-induced [35S]GTPyS Binding: Implications for Coexistence of Multiple Functional Conformatios of Dopamine D1-like Receptors, Journal of Receptors and Signal Transduction, 25 (2), 125-146 (2005).

Klaus Becker, Matthias Eder, Walter Zieglgansberger, Hans-Ulrich Dodt, WIN 55,212-2 Decreases the spatial spread of neocortical excitation in vitro, NeuroReport, 16 (9), 993-996 (2005).

T. J. Price, A. M. Patwardhan, C. M. Flores and K. M. Hargreaves, A Role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons, Neuropharmacology, 49 (1), 25-39 (2005).

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Gerard J. O'Sullivan, Anthony Kinsella, David R. Sibley, Orna Tighe, David T. Croke and John L. Waddington, Ethological resolution of behavioural topography and D1-like versus D2-like agonist responses in congenic D5 dopamine receptor mutants: Identification of D5:D2-like interactions, Synapse, 55 (4), 202-211 (2005).

M. Panjehpour, M. Castro and K. -N. Klotz, Human breast cancer cell line MDA-MB-231 expresses endogenous A 2B adenosine receptors mediating a Ca 2+ signal, British Journal of Pharmacology, 145 (2), 211-218 (2005).

D. Wirtshafter, C.V. Osborn, The atypical dopamine D1 receptor agonist SKF 83959 induces striatal Fos expression in rats, Eur. J. Pharmacol., 528, 88–94 (2005).

W. Ni, C.S. Wilhelm, M. Bader, D.L. Murphy, K. Lookingland, S.W. Watts, (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter. J. Pharmacol. Exp. Ther. Sep;314(3):953-60 (2005).

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T. J. Price, A. Patwardhan, A. N. Akopian and K. M. Hargreaves, Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists, British Journal of Pharmacology, 141, 1118-1130 (2004).

Peter S. Talbot, W. Godon Frankie, Dah-Ren Hwang, Yiyun Huang, Raymond F. Suckow, Mark Slifstein, Anissa Abi-Dargham and Marc Laruelle, Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans, Synapse, 55 (3), 164-175 (2004).

D. P. Finn, S. R. G. Beckett, D. Richardson, D. A. Kendall, C. A. Marsden and V. Chapman, Evidence for differential modulation of coniditioned aversion and fear-conditioned analgesia by CB1 receptors, European Journal of Neuroscience, 20 (3), 848-852 (2004).

Kimberly A. Petrie, Michael Bubser, Cheryl D. Casey, M. Duff Davis, Bryan L. Roth and Ariel Y. Deutch, The Neurotensin Agonist PD14913 Increases Fos Expression in the Prefrontal Cortex of the Rat, Neuropsychopharmacology, 29, 1878-1888 (2004).

P. D. Shilling, G. Melendez, K. Priebe, E. Richelson and D. Feifel, Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT 2A and an a1 agonist, Psychopharmacology, 175 (3), 353-359 (2004).

P. Alexander Arguello and J. David Jentsch, Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat, Psychopharmacology, 177 (1-2), 141-150 (2004).

Yasuyuki Makihara, Hiroshi Yamamoto, Mai Inoue, Katsunori Tomiyama, Noriaki Koshikawa and John L. Waddington, Topographical effects of D1-like dopamine receptor agonistson orofacial movements in mice and their differential regulation via oppositional versus synergistic D1-like: D2-like interactions: cautionary observations on SK&F 82958 as an anomalous agent, Journal of Psychopharmacology, 18 (4), 484-495 (2004).

M. Soaje and R. P. Deis, Involvement of Opioid Receptor Subtypes in Both Stimulatory and Inhibitory Effects of the Opioid Peptides on Prolactin Secretion During Pregnancy, Biomedical and Life Sciences, 24 (2), 193-204 (2004).

David Feifel, Gilia Melendez and Paul D. Shilling, Reversal of Sensorimotor Gating Deficits in Brattleboro Rats by Acute Administration of Clozapine and a Neurotensin Agonist, but not Haloperidol: a Potential predictive model for novel antipsychotic effects, Neuropsychopharmacology, 29, 731-738 (2004).

Theodore J. Price, Amol Patwardhan, Armen N. Akopian, Kenneth M. Hargreaves and Christopher M. Flores Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons, British Journal of Pharmacology, 142, 257-266 (2004).

Jennifer Ronesi, Gregory L. Gerdeman and David M. Lovinger, Disruption of Endocannabinoid Release and Striatal Long-Term Depression by Postsynaptic Blockage of Endocannabinoid Membrane Transport, J. Neurosci., 24 (7), 1673-1679 (2004).

Z. Cao, S. Hallur, H. Z. Qiu, X. Peng and Y. Li, Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicity, Biochem. Biophys. Res. Comm., 316, 1043-1049 (2004).

G. J. O'Sullivan, B. L. Roth, A. Kinsella and J. L. Waddington, SF&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography, Eur. J. Pharmacol., 486, 273-280 (2004).

Margaret I. Davis, Jennifer Ronesi and David M. Lovinger, A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells, J. Biol. Chem., 278 (49), 48973-48980 (2003).

Barbara J. Ebersole, Irache Visiers, Harel Weinstein and Stuart C. Sealfon Molecular Basis of Partial Agonism: Orientation of Indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy, Molecular Pharmacology, 63, (1), 36-43 (2003).

Katsunori Tomiyama, Fergal N. McNamara, Jeremiah H. Clifford, Anthony Kinsella, John Drago, Sara Fuchs, David K. Grandy, Malcolm J. Low, Marcelo Rubinstein, Orna Tighe, David T. Croke, Noriaki Koshikawa and John L. Waddington, Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout", Synapse, 51 (1), 71-81 (2003).

Shahnaz Christina Azad, Matthias Eder, Giovanni Marsicano, Beat Lutz, Walter Zieglgansberger and Gerhard Rammes, Activation of the Cannabinoid Receptor Type 1 Decreases Glutamatergic and GABAergic Synaptic Transmission in the Lateral Amygdala of the Mouse, Learning & Memory, 10l, 116-128 (2003).

R. J. Rodgers, J. Haller, J. Halasz and E. Mikics, 'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevatec plus-maze, European Journal of Neuroscience, 17 (6), 1279-1286 (2003).

Daniela Cota, Giovanni Marsicano, Matthias Tschop, Yvonne Grubler, Cornelia Flachskamm, Mirjam Schubert, Dorothee Auer, Alexander Yassouridis, Christa Thone-Reineke, et. al..., The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis, J. Clinical Investigation, 112, 423-431 (2003).

Christopher D. Verrico, J. David Jentsch, Laura Dazzi and Robert H. Roth, Systemic, but not local, administration of cannabinoid CB1 receptor agonists modulate prefrontal cortical acetylcholine efflux in the rat, Synapse, 48 (4), 178-183 (2003).

K. Tomiyama, F. N. McNamara, J. J. Clifford, A. Kinsella, J. Drago, O. Tighe, D. T. Croke, N. Koshikawa and J. L. Waddington, Phenotypic resolution of spontaneous and D (1)-like agonist-induced orofacial movement topographies in congenic dopamine D receptor ..., Neuropharmacology, 42, 644-652 (2002).

M. Soaje, EG de Di Nasso and R. P. Deis, Regulation by endogenous opioids of suckling-induced prolactin secretion in pregnant and lactating rats: role of ovarian steroids, Journal of Endocrinology, 172 (2), 255-261 (2002).

Giovanni Marsicano, Carsten T. Wotjak, Shahnaz C. Azad, Tiziana Bisogno, Gerhard Rammes, Maria Grazia Cascio, Heike Hermann, Jianrong Tang, Clementine Hofmann, et. al., The endogenous cannabinoid system controls extinction of aversive memories, Nature, 418, 530-534 (2002).

Gregory L. Gerdeman, Jennifer Ronesi and David M. Lovinger, Postsynaptic endocannabinoid release is critical to long-term depression in the striatum, Nature Neuroscience, 5, 446-451 (2002).

Fergal N. McNamara, Jeremiah J. Clifford, Orna Tighe, Anthony Kinsella, John Drago, Sara Fuchs, David T. Croke and John L. Waddington, Phenotypic, ethologically based resolution of spontaneous and D2-like vs. D1-like agonist-induced behavioural topography in mice with congenic D3 dopamine receptor "knockout", Synapse, 46 (1), 19-31 (2002).

Carol A. Tamminga, Charles B. Nemeroff, Randy D. Blakely, Linda Brady, Cameron S. Carter, Kenneth L. Davis, Raymond Dingledine, Jack M. Gorman, Dimitri E. Grigoriadis, et. al., Developing Novel Treatments for Mood Disorders: Accelerating Discovery, Biol. Psychiatry, 52 (6), 589-609 (2002).

Gregory L. Gerdeman, Jennifer Ronesi and David M. Lovinger, Postsynaptic endocannabinoid release is critical to long-term depression in the striatum, Nature Neuroscience, 5 (5), 446-451 (2002).

T. J. DeVries, Y. Shaham, J. R. Homberg, H. Crombag, K. Schurman, J. Dieben, L.J.M.J. Vanderschuren, and A.N.M. Schoffelmeer A cannabinoid mechanism in relapse to cocaine seeking Nature Med 7, 1151 (2001).

S. Panchalingam and A. S. Undie, SKF83959 exhibits biochemical agonism by stimulating [ S]GTP ?S binding and phosphoinositide hydrolysis in rat and monkey brain, Neuropharmacology, 40, 826-837 (2001).

A. K. Patni, S. Gupta, A. Sharma, A. K. Tiwary, and S. K. Garg Role of intracellular calcium in the spermicidal action of 2',4'-dichlorobenzamil, a novel contract spermicide, J. Pharm. Pharmacol. 53, 1387-1392 (2001).

P. R. Reddy, A. Patni, A. Sharma, S. Gupta, and A. K. Tiwary Effect of 2',4'-dichlorobenzamil hydrochloride, a Na +-Ca 2+ exchange inhibitor, on human spermatozoa Eur. J. Pharmacol. 418, 153-155 (2001).

N. Safran, V. Shneyvays, N. Balas, K. A. Jacobson, H. Nawarth, and A. Shainberg Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes Mol. Cell. Biochem 217, 143-152 (2001).

V. Shneyvays, L. Mamedova, T. Zinman, K. Jacobson, and A. Shainberg Activation of A 3adenosine receptor protects against doxorubicin-induced cardiotoxicity J. Mol. Cell Cardiol 33, 1249-1261 (2001).

D. Bridges, K. Ahman and A. S.C. Rice, The Synthetic Cannabinoid WIN55, 212-2 attenuates hyperalgesia and allodynia in a rat model of ...., British Journal of Pharmacology, 133, 586-594 (2001).

Gregory Gerdeman and David M. Lovinger, CB1 Cannabinoid Receptor Inhibits Synaptic Release of Glutamate in Rat Dorsolateral Striatum, Journal of Neurophysiology, 85 (1), 468-471 (2001).

T. Obsil, R. Ghirlando, D. Klein, S. Ganguly and F. Dyda, Crystal Structure of the 14-3-3?: Serotonin N-acetyltransferase Complex A role for scaffolding in enzyme regulation, Cell, 105 (2), 257-267 (2001).

I. A. Antonijevic, J. A. Russell, R. J. Bicknell, G. Leng and A. J. Douglas, Effect of progesterone on the activation of neurones of the supraoptic nucleis during parturition, Journal of Reproduction and Fertility, 120, 367-376 (2000).

F. Dyda, D. C. Klein, and A. B. Hickman. GCN5-related N-acetyltransferases: A structural overview. Annu. Rev. Biophys. Biomol. Struct. 29, 81-103 (2000).

S. W. Rhee and M. J. Tanga Synthesis of tritium labelled 4P-PDOT, a selective melatonin receptor antagonist J. Labelled Cpd. Radiopharm 43, 925-932 (2000)

V. Shneyvays, K. A. Jacobson, A.-H. Li, H. Nawrath, T. Zinman, A. Issac, and A. Shainberg Induction of apoptosis in rat cardiocytes by A3 adenosine receptor activation and its suppression by isoproterenol Exp. Cell Res 257, 111-126 (2000).

T. V. Dunwiddie, K. A. Jacobson, and L. Diao. An adenosine A 3receptor-selective agonist does not modulate calcium-activated potassium currents in hippocampal CA1 pyramidal neurons. Progr. Brain Res. 120, 275-285 (P. Illes and H. Zimmermann, Eds.), (1999).

A. B. Hickman, M. A. A. Namboodiri, D. C. Klein and F. Dyda, The structural basis of ordered substrate binding by serotonin N-acetyltransferase: Enzyme complex at 1.8 Angstrom resolution with a bisubstrate analog, Cell, 97, 361-369 (1999).

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David Fulton and John Quilley Evidence against Anandamide as the Hyperpolarizing Factor Mediating the Nitric Oxide-Independent Coronary Vasodilator Effect of Bradykinin in the Rat, J. Pharmacology and Experimental Therapeutics, 286 (3), 1146-1151 (1998).

M. Soaje and R. P. Deis, Opioidergic Regulation of Prolactin Secretion During Pregnancy: role of ovarian hormones, Journal of Endocrinology, 155 (1), 99-106 (1997).

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About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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