NIMH Chemical Synthesis and Drug Supply Program

Publications

The NIMH is eager to be apprised of publications resulting from use of the Chemical Synthesis and Drug Supply Program (CSDSP)compounds it has supplied. In light of budgetary restrictions, The CSDSP frequently needs to justify its existence. If you find its service useful, please keep the CSDSP informed of your published results (see contacts).

In addition, please indicate in the Materials & Methods section of your publication that the compounds were obtained from the NIMH Chemical Synthesis and Drug Supply Program. If you are aware of key references about CSDSP compounds, please contact the CSDSP and the references will be added to the compound information page.

NIMH CSDSP referencing publications:


Koster, K.P., Flores-Barrera, E., de la Villarmois, E.A., Caballero, A., Tseng, K.Y. and Yoshii, A., Loss of Depalmitoylation Disrupts Homeostatic Plasticity of AMPARs in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis, Journal of Neuroscience, 6 December 2023, 43 (49) 8317-8335.

Lawson, K. A., Ruiz, C. M., & Mahler, S. V., A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition, Psychopharmacology, 240(10), 2101-2110 (2023).

Cope, E.C., Wang, S.H., Waters, R.C., Gore, I.R., Vasquez, B., Laham, B.J. and Gould, E., Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice, Nature communications, 14(1), p.1750 (2023).

Ogbeide-Latario, O.E., Ferrari, L.L., Gompf, H.S., Anaclet, C., Two novel mouse models of slow-wave-sleep enhancement in aging and Alzheimer’s disease, Sleep Advances, 3(1), p.zpac022 (2022).

L. L. Ferrari, O. E. Ogbeide-Latario, H. S. Gompf, C. Anaclet, Validation of DREADD agonists and administration route in a murine model of sleep enhancement, Journal of Neuroscience Methods, 380, 109679 (2022).

W.T. Doucette, E.B. Smedley, M. Ruiz-Jaquez, J.Y. Khokhar, K.S. Smith, Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet, Brain Research, 1784, p.147886 (2022).

K.A. Amaya, K.S. Smith, Spatially restricted inhibition of cholinergic interneurons in the dorsolateral striatum encourages behavioral exploration, European Journal of Neuroscience, 53(8), pp.2567-2579 (2021).

W.S. Kim, J. Liu, Q. Li, S. Hong, K. Qi, R. Cherukuri, B.-J. Yoon, J. Moscarello, Y. Choe, S. Maren, S. Il Park, AI-driven high-throughput automation of behavioral analysis and dual-channel wireless optogenetics for multiplexing brain dynamics, bioRxiv, 09.23.461279 (2021); doi.org/10.1101/2021.09.23.461279.

R.L. Ressler, T.D. Goode, S. Kim, K.R. Ramanathan, S. Maren, Covert capture and attenuation of a hippocampus-dependent fear memory, Nat Neurosci. 24(5):677-684 (2021).

Saucisse N, Mazier W, Simon V, Binder E, Catania C, Bellocchio L, Romanov RA, Léon S, Matias I, Zizzari P, Quarta C., Functional heterogeneity of POMC neurons relies on mTORC1 signaling, Cell Reports, 2021 Oct 12;37(2):109800.

Manning EE, Geramita MA, Piantadosi SC, Pierson JL, Ahmari SE., Distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine, Biological Psychiatry, 2021 Nov 27.

Wu T, Zhu J, Strickland A, Ko KW, Sasaki Y, Dingwall CB, Yamada Y, Figley MD, Mao X, Neiner A, Bloom AJ., Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss, Cell reports, 2021 Oct 19;37(3):109872.

Manning EE, Geramita MA, Piantadosi SC, Ahmari SE., Independent and distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine, bioRxiv, 2021 Jan 1.

Yates JR, Horchar MJ, Ellis AL, Kappesser JL, Mbambu P, Sutphin TG, Dehner DS, Igwe HO, Wright MR., Differential effects of glutamate N-methyl-d-aspartate receptor antagonists on risky choice as assessed in the risky decision task, Psychopharmacology, 2021 Jan;238(1):133-48.

Wang Y, Guo R, Chen B, Rahman T, Cai L, Li Y, Dong Y, Tseng GC, Fang J, Seney ML, Huang YH., Cocaine-induced neural adaptations in the lateral hypothalamic melanin-concentrating hormone neurons and the role in regulating rapid eye movement sleep after withdrawal, Molecular psychiatry, 2021 Jul;26(7):3152-68.

Hupalo S, Spencer RC, Berridge CW., Prefrontal corticotropin-releasing factor neurons impair sustained attention via distal transmitter release, European Journal of Neuroscience, 2021 Jul 1;54(1):4182-96.

Satanove DJ, Rahman S, Chan TM, Ren S, Clarke P., Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects, Psychopharmacology, 2021 Feb;238(2):475-86.

Laham BJ, Diethorn EJ, Gould E., Newborn mice form lasting CA2-dependent memories of their mothers, Cell reports, 2021 Jan 26;34(4):108668.

Delevich K, Hall CD, Wilbrecht L., Prepubertal ovariectomy alters dorsomedial striatum indirect pathway neuron excitability and explore/exploit balance in female mice, bioRxiv. 2021 Jan 1.

Duin AA, Aman L, Schmidt B, Redish AD., Certainty and uncertainty of the future changes planning and sunk costs, Behavioral Neuroscience, 2021 Jun 24.

Koczor CA, Saville KM, Andrews JF, Clark J, Fang Q, Li J, Al-Rahahleh RQ, Ibrahim M, McClellan S, Makarov MV, Migaud ME., Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis, Cell reports, 2021 Nov 2;37(5):109917.

J.P. Bauer, S.L. Rader, M.E. Joffe, W. Kwon, J. Quay, L. Seanez, C. Zhou, P.J. Conn, A.S. Lewis, Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus, bioRxiv, pp.2020-12 (2021).

L.A. Bradfield, B.K. Leung, S. Boldt, S. Liang, B.W. Balleine, Goal-directed actions transiently depend on dorsal hippocampus, Nature Neuroscience, 23(10), pp.1194-1197 (2020).

S. Gasparini, J.M. Resch, A.M. Gore, L. Peltekian, J.C. Geerling, Pre-locus coeruleus neurons in rat and mouse, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Dec 9. doi: 10.1152/ajpregu.00261.2020.

S. Liu, M. Ye, G.M. Pao, S.M. Song, J. Jhang, S. Han, Identification of a novel breathing circuit that controls pain and anxiety, BioRxiv. 2020 Jan 1.

W. Francesconi, F. Berton, V. Olivera-Pasilio, J. Dabrowska, Oxytocin selectively excites interneurons and inhibits output neurons of the bed nucleus of the stria terminalis (BNST), bioRxiv. (2020).

K.R. Coffey, R.G. Marx, E.K. Vo, S.G. Nair, J. F. Neumaier, Chemogenetic inhibition of lateral habenula projections to the dorsal raphe nucleus reduces passive coping and perseverative reward seeking in rats, Neuropsychopharmacology, 45(7), 1115–1124 (2020), doi.org/10.1038/s41386-020-0616-0.

J.M. Moscarello, Prefrontal cortex projections to the nucleus reuniens suppress freezing following two-way signaled avoidance training, Learning & Memory, 27(3), pp.119-123 (2020).

L.Y. Brown, G.M. Alexander, J. Cushman, S.M. Dudek, Hippocampal CA2 organizes CA1 slow and fast ? oscillations during novel social and object interaction, Eneuro, 2020, 7(2).

C. Abe, Y. Yamaoka, Y. Maejima, T. Mikami, S. Yokota, A. Yamanaka, H. Morita, VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice, Communications Biology, 3, 227 (2020).

N. Nawreen, R. Morano, P. Mahbod, E.M. Cotella, K. Dalal, M. Fitzgerald, S. Martelle, B.A. Packard, R.D. Moloney, J.P. Herman, Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABA-ergic Parvalbumin-positive Interneurons Attenuates Chronic Stress Adaptions in Male Mice, eNeuro, 7(5), ENEURO.0423-19.2020. https://doi.org/10.1523/ENEURO.0423-19.2020

T.F. Giustino, K.R. Ramanathan, M.S. Totty, O.W. Miles, S. Maren, Locus coeruleus norepinephrine drives stress-induced increases in basolateral amygdala firing and impairs extinction learning, Journal of Neuroscience, 40(4), 907-916 (2020).

K.A. Amaya, J.J. Stott, K.S. Smith, Sign-tracking behavior is sensitive to outcome devaluation in a devaluation context-dependent manner: implications for analyzing habitual behavior, Learning & Memory, 27(4), 136-149 (2020).

E.B. Smedley, A. DiLeo, K.S. Smith, Circuit directionality for motivation: lateral accumbens-pallidum, but not pallidum-accumbens, connections regulate motivational attraction to reward cues, Neurobiology of Learning and Memory, 162, pp.23-35(2019).

T.F. Giustino, P.J. Fitzgerald, R.L. Ressler, S. Maren, Locus coeruleus toggles reciprocal prefrontal firing to reinstate fear, Proceedings of the National Academy of Sciences, 116(17), 8570-8575 (2019).

A.F. Scheyer, M. Borsoi, J. Wager-Miller, A-L. Pelissier-Alicot, M.N. Murphy, K. Mackie, O.J.J. Manzoni, Cannabinoid exposure via lactation in rats disrupts perinatal programming of the GABA trajectory and select early-life behaviors, Biological Psychiatry, 2019-09, DOI: 10.1016/j.biopsych.2019.08.023.

B. Chamberlain, Investigating the role of striatal spiny projection neurons in compulsive behaviors, Undergraduate Thesis, University of Pittsburgh (2019).

S. Crowel, An Examination of Affective Blunting in Rodents, All NMU Master's Theses, 598 (2019).

B. Schmidt, A.A. Duin, A.D. Redish, Disrupting the medial prefrontal cortex alters hippocampal sequences during deliberative decision making, Journal of Neurophysiology, 121(6), 1981-2000 (2019).

N.R. Sciolino, C.M. Mazzone, N.W. Plummer, I. Evsyukova, J. Amin, K.G. Smith, C.A. McGee, S.A. Fry, C.X. Yang, J.M. Powell, M.R. Bruchas, A role for the locus coeruleus in the modulation of feeding, bioRxiv, 12.18.881599 (2019).

E.T.N.M.A. Erickson, L.L. Ferrari, H.S. Gompf, C. Anaclet, Differential role of pontomedullary glutamatergic neuronal populations in sleep-wake control, Frontiers in Neuroscience,. 13, 755 (2019).

E.E. Manning, A.Y. Wang, L.M. Saikali, A. Winner, S.E. Ahmari, Disruption of prepulse inhibition is associated with severity of compulsive behavior and nucleus accumbens dopamine system changes in Sapap3 knockout mice, bioRxiv, 694935 (2019).

P.D. Skelton, J. Poquerusse, J.R. Salinaro, M. Li, B.W. Luikart, Activity-dependent dendritic elaboration requires Pten, Neurobiology of Disease, 104703 (2019).

A.T. Slominski, T.K. Kim, K. Kleszczynski, I. Semak, Z. Janjetovic, T. Sweatman, C. Skobowiat, J.D. Steketee, Z. Lin, A. Postlethwaite, W. Li, Characterization of Serotonin and N-acetylserotonin Systems in the Human Epidermis and Skin Cells, Journal of Pineal Research, 2019.

K. Delevich, B. Hoshal, A.G. Collins, L. Wilbrecht, Choice suppression through opponent but not independent function of the striatal indirect pathway, bioRxiv, 675850 (2019).

M.B. Pomrenze, S.M. Giovanetti, R. Maiya, A.G. Gordon, L.J. Kreeger, R.O. Messing, Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning, Cell Reports, 29(1), 13-21 (2019).

A.L. Halberstadt, J.V. van der Zee, M. Chatha, M.A. Geyer, S.B. Powell, Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen, Psychopharmacology, 236(2): 821-830 (2019).

A.M. Van Dyke, T.C. Francis, H. Chen, A.M. Bailey, S.M. Thompson, Chronic fluoxetine treatment in vivo enhances excitatory synaptic transmission in the hippocampus, Neuropharmacology, 150, 38-45 (2019).

J.M. Kott, S.M. Mooney-Leber, S. Brummelte, Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression, Behavioural Brain Research, 366, 1-12 (2019).

S. Schiavi, A. Manduca, M. Segatto, P. Campolongo, V. Pallottini, L.J.M.J. Vanderschuren, V. Trezza, Unidirectional opioid-cannabinoid cross-tolerance in the modulation of social play behavior in rats, Psychopharmacology, doi: 10.1007/s00213-019-05226-y (2019).

E.A. Choi, P. Jean-Richard-dit-Bressel, C.W.G. Clifford, G.P. McNally, Paraventricular thalamus controls behavior during motivational conflict, Journal of Neuroscience, doi: 10.1523/JNEUROSCI.2480-18.2019 (2019).

M.B. Pomrenze, J. Tovar-Diaz, A. Blasio, R. Maiya, S.M. Giovanetti, K. Lei, H. Morikawa, F.W. Hopf, and R.O. Messing, A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety, J. Neuroscience, 6 February 2019, 39 (6) 1030-1043; DOI: 10.1523/JNEUROSCI.2143-18.2018 (2019).

G. de Guglielmo, M. Kallupi, M.B. Pomrenze, E. Crawford, S. Simpson, P. Schweitzer, G.F. Koob, R.O. Messing, O. George, Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 18 Mar 2019, 10(1):1238. DOI: 10.1038/s41467-019-09183-0 (2019).

B. Halbout, A.T. Marshall, A. Azimi, M. Liljeholm, S.V. Mahler, K.M. Wassum, S.B., Ostlund, Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats, Elife, 8, p.e43551 (2019).

G.M. Alexander, N.V. Riddick, K.E. McCann, D. Lustberg, S.S. Moy, S.M. Dudek, Modulation of CA2 neuronal activity increases behavioral responses to fear conditioning in female mice, Neurobiology of Learning and Memory, 163, p.107044 (2019).

D. Martinon, P. Lis, A.N. Roman, P. Tornesi, S.V. Applebey, G. Buechner, V. Olivera, J. Dabrowska, Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear, Translational Psychiatry, 9(1), pp.1-13 (2019).

D.I. Fournier, T.P. Todd, D.J. Bucci, Permanent damage or temporary silencing of retrosplenial cortex impairs the expression of a negative patterning discrimination, Neurobiology of Learning and Memory, 163, p.107033 (2019).

C.A. Bouchet, M.A. Miner, E.C. Loetz, A.J. Rosberg, H.S. Hake, C.E. Farmer, M. Ostrovskyy, N. Gray, B.N. Greenwood, Activation of nigrostriatal dopamine neurons during fear extinction prevents the renewal of fear, Neuropsychopharmacology, 43(3), pp.665-672 (2018).

J. Taura, E.G. Nolen, G. Cabré, J. Hernando, L. Squarcialupi, M. López-Cano, K.A. Jacobson, V. Fernández-Dueñas, F. Ciruela, Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist, Journal of Controlled Release, 283, 135-142 (2018).

C. Anacker, V.M. Luna, G.S. Stevens, A. Millette, R. Shores, J.C. Jimenez, B. Chen, R. Hen, Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus, Nature, 559(7712), pp.98-102 (2018).

G. Hart, L.A. Bradfield, S.Y. Fok, B. Chieng, B.W. Balleine, The bilateral prefronto-striatal pathway is necessary for learning new goal-directed actions, Current Biology, 28(14), pp.2218-2229 (2018).

G.M. Alexander, L.Y. Brown, S. Farris, D. Lustberg, C. Pantazis, B. Gloss, N.W. Plummer, P. Jensen, S.M. Dudek, CA2 neuronal activity controls hippocampal low gamma and ripple oscillations, Elife, 7, p.e38052 (2018).

D. Neuhofer, O. Lassalle, O.J. Manzoni, Muscarinic M1 receptor modulation of synaptic plasticity in nucleus accumbens of wild-type and fragile X mice, ACS chemical neuroscience, 9(9), pp.2233-2240 (2018).

E.M. McGlinchey & G. Aston-Jones, Dorsal hippocampus drives context-induced cocaine seeking via inputs to lateral septum, Neuropsychopharmacology, 43, 987–1000 (2018).

L. Boekhoudt, E.C. Wijbrans, J.H.K. Man, M.C.M. Luijendijk, J.W. de Jong, G. van der Plasse, L.J.M.J. Vanderschuren, R.A.H. Adan, Enhancing excitability of dopamine neurons promotes motivational behaviour through increased action initiation, Eur. Neuropsychopharm. 28, 1, 171-184 (2018).

J.P.H. Verharen, J.W. de Jong, T.J.M. Roelofs, C.F.M. Huffels, R. van Zessen, M.C.M. Luijendijk, R. Hamelink, I. Willuhn, H.E.M. den Ouden, G. van der Plasse, R.A.H. Adan, L.J.M.J. Vanderschuren, A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states, Nature Communications, 9, 731 (2018).

R. Marek, J. Jin, T.D. Goode, T.F. Giustino, Q. Wang, G.M. Acca, R. Holehonnur, J.E. Ploski, P.J. Fitzgerald, T. Lynagh, J.W. Lynch, S. Maren, P. Sah, Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear, Nature Neuroscience, 21, 384–392 (2018).

E.F. Gallo, J. Meszaros, J.D. Sherman, M.O. Chohan, E. Teboul, C.S. Choi, H. Moore, J.A. Javitch, C. Kellendonk, Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum, Nature Communications, Mar 14;9(1):1086 (2018), doi: 10.1038/s41467-018-03272-2.

Y. Cheng, The role of dopamine D1 and D2 receptor-expressing striatal neurons in the corticostriatal circuitry of alcohol use disorder, Doctoral dissertation, Texas A & M University (2018).

K.R. Ramanathan, J. Jin, T.F. Giustino, M.R. Payne, S. Maren, Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction, Nature communications, 9, 4527 (2018).

T.A. LeGates, M.D. Kvarta, J.R. Tooley, T.C. Francis, M.K. Lobo, M.C. Creed, S.M. Thompson, Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses, Nature, 564, 258 (2018).

J. Zhang, C. Chen, Alleviation of neuropathology by inhibition of monoacylglycerol lipase in APP transgenic mice lacking CB2 receptors, Molecular Neurobiology, 55:4802-4810 (2018).

*P.M. Grace, X. Wang, K.A. Strand, M.V. Baratta, Y. Zhang, E.L. Galer, H. Yin, S.F. Maier, L.R. Watkins, DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats. Experimental Neurology, 304, 125–131, doi:10.1016/j.expneurol.2018.03.005 (2018).

*S.D. Dolzani, M.V. Baratta, J.M. Moss, N.L. Leslie, S.G. Tilden, A.T. Sørensen, L.R. Watkins, Y. Lin, S.F. Maier, Inhibition of a descending prefrontal circuit prevents ketamine-induced stress resilience in females, eNeuro, 5(1), ENEURO.0025-18.2018, doi:10.1523/ENEURO.0025-18.2018

D. Avesar, E.K. Stephens, A.T. Gulledge, Serotonergic regulation of corticoamygdalar neurons in the mouse prelimbic cortex, Frontiers in Neural Circuits, 12:63 (2018), doi: 10.3389/fncir.2018.00063.

E.K. Stephens, A.L. Baker, A.T. Gulledge, Mechanisms underlying serotonergic excitation of callosal projection neurons in the mouse medial prefrontal cortex, Frontiers in Neural Circuits, 12:2, doi:10.3389/fncir.2018.00002 (2018).

A. Bara, A. Manduca, A. Bernabeu, M. Borsoi, M. Serviado, O. Lassalle, M. Murphy, J. Wager-Miller, K. Mackie, A-L. Pelissier-Alicot, V. Trezza, O.J. Manzoni Sex-dependent effects of in utero cannabinoid exposure on cortical function, eLife, 2018-09-11, DOI: 10.7554/eLife.36234.

S.E. Chang, T.P. Todd, K.S. Smith, Paradoxical accentuation of motivation following accumbens-pallidum disconnection, Neurobiology of learning and memory, 149, pp.39-45 (2018).

C. Anaclet, K. Griffith, P.M. Fuller, Activation of the GABAergic Parafacial Zone Maintains Sleep and Counteracts the Wake-Promoting Action of the Psychostimulants Armodafinil and Caffeine, Neuropsychopharmacology, Jan;43(2):415-425 (2018).

C. Anaclet, R. De Luca, A. Venner, O. Malyshevskaya, M. Lazarus, E. Arrigoni, P.M. Fuller, Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control, J. Neurosci. May 30;38(22):5168-5181 (2018).

D.F. Manvich, K.A. Webster, S.L. Foster, M.S. Farrell, J.C Ritchie, J.H. Porter, D. Weinshenker, The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice, Scientific Reports, 8(1), 1-10 (2018).

M. Borsoi, A. Manduca, A. Bara, O. Lassalle, A.L. Pelissier-Alicot, O.J. Manzoni, Sex differences in the behavioral and synaptic consequences of a single exposure to cannabinoid at puberty and adulthood, bioRxiv, p.415067 (2018).

J.L. Carlin, S. Jain, R. Duroux, R.R. Suresh, C. Xiao, J.A. Auchampach, K.A. Jacobson, O. Gavrilova, M.L. Reitman, Activation of adenosine A2A or A2B receptors causes hypothermia in mice, Neuropharmacology, https://doi.org/10.1016/j.neuropharm.2018.02.035 (2018).

J.M. Kott, S.M. Mooney-Leber, J. Li, S. Brummelte, Elevated stress hormone levels and antidepressant treatment starting before pregnancy affect maternal care and litter characteristics in an animal model of depression, Behavioural. Brain Res., 348, 101-114 (2018).

C. Dumon, D. Diabira, I. Chudotvorova, F. Bader, G.S. Sahin, J. Zhang, C. Porcher, G. Wayman, I. Medina, J-L. Gaiarsa, The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice, eLife , 7, e36726 (2018).

P. Ratano, C. Petrella, F. Forti, P.P. Passeri, M. Morena, M. Palmery, V. Trezza, C. Severini, P. Campolongo, Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation, Neuropharmacology, 138, 210-218 (2018).

M. Wickert, K.L. Hildick, G.L. Baillie, R. Jelinek, A. Aparisi Rey, K. Monory, M. Schneider, R. Ross, J. Henley, B. Lutz, The F238L point mutation in the cannabinoid type-1 receptor enhances basal endocytosis via lipid rafts, Frontiers in Molecular Neuroscience, 11, 230 (2018).

J.I. Yoo, M.A. O’Malley, Tuning vector stability and integration frequency elevates functional GPCR production and homogeneity in saccharomyces cerevisiae, ACS Synth. Biol., 7 (7), 1763–1772 (2018).

N.A. Upright, S.W. Brookshire, W. Schnebelen, C.G. Damatac, P.R. Hof, P.G.F. Browning, P.L. Croxson, P.H. Rudebeck, M.G. Baxter, Behavioral effect of chemogenetic inhibition is directly related to receptor transduction levels in rhesus monkeys, J. Neuroscience, 6 August 2018, 1422-18 (2018).

E.T. Baltz, E.A. Yalcinbas, R. Renteria, C.M. Gremel, Orbital frontal cortex updates state-induced value change for decision-making, eLife, 7, e35988 (2018).

C-Y. Yeh, B. Asrican, J. Moss, L.J. Quintanilla, T. He, X. Mao, F. Cassé, E. Gebara, H. Bao , W. Lu, N. Toni, Mossy cells control adult neural stem cell quiescence and maintenance through a dynamic balance between direct and indirect pathways, Neuron (2018).

G.A. Kane, Behavioral and neural mechanisms of patch foraging, ProQuest Dissertations Publishing, Princeton University 10814299 (2018).

K.N. Swonger, A.S. Robinson, Using fluorescence anisotropy for ligand binding kinetics of membrane proteins, Current Protocols in Protein Science, 93(1), p.e63 (2018).

K.B. Karunakaran, S. Chaparala, M.K. Ganapathiraju, Potentially repurposable drugs for schizophrenia identified from its interactome, bioRxiv, 442640 (2018).

Y. Zhang, F. Liu, H. Xiao, X. Yao, G. Li, S.R. Choi, K. Ploessl, Z. Zha, L. Zhu, H.F. Kung, [18F] Diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain, Nuclear Medicine and Biology, 66, 1-9 (2018).

J. Cummings, C. Reiber, P. Kumar, The price of progress: Funding and financing Alzheimer's disease drug development, Alzheimer's & Dementia: Translational Research & Clinical Interventions, 4, 330-343 (2018).

A.L. Halberstadt, J.V. van der Zee, M. Chatha, M.A. Geyer, S.B. Powell, Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen, Psychopharmacology, 1-10 (2018).

P.M. McNeely, A.N. Naranjo, K. Forsten-Williams, A.S. Robinson, A2AR Binding Kinetics in the Ligand Depletion Regime, SLAS DISCOVERY: Advancing Life Sciences R&D, 22(2), 166–175 (2017).

E.K. Kirschmann, D.M. McCalley, C.M. Edwards, M.M. Torregrossa, Consequences of adolescent exposure to the cannabinoid receptor agonist WIN55,212-2 on working memory in female rats, Front. Behav. Neurosci., 11, 137, doi: 10.3389/fnbeh.2017.00137 (2017).

G.A. Kane, E.M. Vazey, R.C. Wilson, A. Shenhav, N.D. Daw, G. Aston-Jones, J.D. Cohen, Increased locus coeruleus tonic activity causes disengagement from a patch-foraging task, Cognitive, Affective, & Behavioral Neuroscience, 17, 6, 1073–1083 (2017), doi.org/10.3758/s13415-017-0531-y.

E. Goubert, Y. Mircheva, F.M. Lasorsa, C. Melon, E. Profilo, J. Sutera, H. Becq, F. Palmieri, L. Palmieri, L. Aniksztejn, F. Molinari, Inhibition of the mitochondrial glutamate carrier SLC25A22 in astrocytes leads to intracellular glutamate accumulation, Front. Cell. Neurosci., 11, 149 (2017).

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A. Das, G.J. Sanjayan, M. Kecskes, L. Yoo, Z.G. Gao, and K.A. Jacobson, Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists, J. Nanobiotechnology, 8, 11-29 (2010)

J.B. Tang, E.M. Goeliner, X.H. Wang, R.N. Trivedi, C.M. St. Croix, E. Jelezcova, D. Svilar, A.R. Brown, and R.W. Sobol, Bioenergetic Metabolites Regulate Base Excision Repair-Dependent Cell Death in Response to DNA Damage, Molecular Cancer Research, 8 (1), 67-79 (2010)

E.L. Dimitrox, E. Petrus, and T.B. Usdin, Tuberoinfundibula peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception, Experimental Neurology, 226, 68-83 (2010)

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G. Zoppoli, M. Cea, D. Soncini, F. Fruscione, J. Rudner, E. Moran, I. Caffa, D. Bedognetti, G. Motta, R. Ghio, F. Ferrando, A. Ballestrero, S. Parodi, C. Belka, F. Patrone, S. Bruzzone, and A. Nencioni, Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells, Experimental Hematology 38, 979-988 (2010)

L. Zhu, Y. Liu, K. Plossl, B. Lieberman, J. Liu, and H.F. Kung, An Improved radiosynthesis of [18F]AV-133: a PET imaging agent for vesicular monoamine transporter 2, Nuclear Medicine and Biology, 37, 133-141 (2010)

D.R. Sagar, M.D. Jhaven, D. Richardson, R.A. Gray, E. De Lago, J. Fernandez-Ruiz, D.A. Barrett, D.A. Kendall, and V. Chapman, Endocannabinoid regulation of spinal nociceptive processing in a model of neuropathic pain, European Journal of Neuroscience, 31 (8), 1414-1422 (2010)

M.E. Bardgett, M. Points, J. Kleier, M. Blankensip, and M.S. Griffith, The H3 antagonist, ciproxifan, alleviages the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats, Neuropharmacology, 59, 492-502, (2010)

S. Trazzi, M. Steger, V.M. Mitrugno, R. Bartesaghi, and E. Ciani, CB1 Cannabinoid receptors increase neuronal precursor proliferation through AKT/Glycogen synthase kinase-3beta/beta-catenin signaling, J. Biol. Chem., 285, 10098-10109 (2010)

K. Mmich, D.P. Finn, E. Dowd, and A.M. Gorman, Inhibition by Anandamide of 6-hydroxydopamine-induced cell death in PC12 cells, International Journal of Cell Biology, Article ID 818497, 10 pages (2010)

D. Feifel, J. Goldenberg, G. Melendez and P.D. Shilling, The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperature, Neuropharmacology, 58, 195-198 (2010)

C. Norman, S. Grimond-Billa, G. Bennett and H. Cassaday, A neurotensin agonist and antagonist decrease and increase activity, respectively, but do not preclude discrete cue conditioning, J. Psychopharmacology, 24 (3), 373-381 (2010)

A.N. Madsen, J. Jelsing, E.H.E.M van de Wall, N. Vrang, P.J. Larsen and G.J. Schwartz, Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents, Neuroscience Letters, 449, 20-23 (2009)

M.B. Gopinathan and K.S. Rehder, An Improved synthesis of (4-{4-hydroxy-3-isopropyl-5-[(4-nitrophenyl)ethynyl]benzyl}-3,5-dimethylphenoxy)acetic acid (NH-3), Synthesis, No. 9, 1428-1430 (2009)

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M. B. Gopinathan, C. Jin, and K. S. Rehder, A Short and Efficient Synthesis of 3-{2-[2-(Bromomethyl)thiazol-4-yl]ethynyl}-5-fluorobenzonitrile: A Precursor for PET Radioligand [18F]SP203, Synthesis, 12, 1979-1982 (2009)

S.C. Azad, J. Kurz, G. Marsicano, B. Lutz, W. Zieglgansberger, and G. Rammes, Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala, Learning & Memory, 15, 143-152 (2009)

D. Feifel, S. Mexal, G. Melendez, P.Y.T. Liu, J.R. Goldenberg, and P.D. Shilling, The Brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and A neurotensin analog, Neuropsychopharmacology, 34, 2011-2018 (2009)

T. Sun, G. Hu and L. Ming, Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibiton on amphetamine-induced hyperlocomotion: Relevance to animal models of antipsychotic drugs, Eur. J. Pharmacology, 602, 334-342 (2009)

P. Lafenetre, F. Chaouloff and G. Marsicano, Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system, Neuropharmacology, 57, 715-721 (2009)

Y. Arakane, J. Lomakin, R. W. Beeman, S. Muthukrishnan, S. H. Gehrke, M. R. Kanost and K. J. Kramer Molecular and functional analyses of amino acid decarboxylases involved in cuticle tannng in Tribolium castaneum J. Biol. Chem. 284 (24), 16584-16594 (2009)

J.L. Wiley and R. L. Evans, To breed or not to breed? Empirical evaluation of drug effects in adolescent rats, Int. J. Devl. Neuroscience, 27, 9-20 (2009)

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M. Li, W. He and A. Mead, Olanzapine and risperidone disrupt conditioned avoidance responding in phencyclidine-pretreated or amphetamine-pretreated rats by selectively weakening motivational salience of conditioned stimulus, Behavioural Pharmacology, 20 (1), 84-98 (2009)

C.J. Sun, S. Srivastva, J.R. Reifert and J.H. Waite, Halogenated DOPA in a marine adhesive protein, The Journal of Adhesion, 85 (2 & 3), 126-138 (2009)

R.K. McNamara, J. Able, R. Jandacek, T. Rider, P. Tso and D.M. Lindquist, Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo 1H-MRS study, Journal of Lipid Research, 50, 405-411 (2009)

Y. Kim, B. Hechler, Z.G. Gao, C. Gachet, and K.A. Jocobson, PEGylated Dendritic Unimolecular Micelles as Versatile Carriers for Ligands of G Protein-Coupled Receptors, Bioconjugate Chemistry, 20, 1888-1898 (2009)

D.C. Chiara, A.K. Hamouda, M.R. Ziebell, L.A. Mejia, G. Garcia III, and J.B. Cohen, [3H]Chlorpromazine Photolabeling of the Torpedo Nicotinic Acetylchloline Receptor Identifies Two State-Dependent Binding Sies in the Ion Channel, Biochemistry, 48 (42), 10066-10077 (2009)

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J.L. Wiley and R.L. Evans, Evaluation of age and sex differences in locomotion and catalepsy during repeated administration of haloperidol and clozapine in adolescent and adult rats, Pharmacological Research, 58, 240-246 (2008)

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D. Feifel, G. Melendez, R.J. Murray, D.N.T. Tran, M.A. Rullan and P.D. Shilling The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit tolerance, Psychopharmacology, 200, 197-203 (2008)

J. Zhang and C. Chen, Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation, The Journal of Biological Chemistry, 283 (33), 22601-22611 (2008)

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K.G. Boldt, G.A. Brine and K. Rehder, Synthesis of (+)-9-O-Desmethyl-a-dihydrotetrabenazine, precursor for the high affinity VMAT2 imaging pet radioligand (11c)-(+)-a-dihydrotetrabenazine, Organic Preparations and Procedures International, 40 (4), 379-384 (2008).

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G. Manikumar, C. Jin and K. S. Rehder, Convenient Synthesis of Tolcapone, a Selective Catechol-O-methyltransferase Inhibitor, Synth. Commun., 38 (5), 810-815 (2008).

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Jaime M. Hatcher, Jason R. Richardson, Thomas S. Guillot, Alison L. McCormack, Donato A. DiMonte, Dean P. Jones, Kurt D. Pennell and Gary W. Miller, Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system, Experimental Neurology, 204, 619-630 (2007).

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Klaus Becker, Matthias Eder, Walter Zieglgansberger, Hans-Ulrich Dodt, WIN 55,212-2 Decreases the spatial spread of neocortical excitation in vitro, NeuroReport, 16 (9), 993-996 (2005).

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Peter S. Talbot, W. Godon Frankie, Dah-Ren Hwang, Yiyun Huang, Raymond F. Suckow, Mark Slifstein, Anissa Abi-Dargham and Marc Laruelle, Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans, Synapse, 55 (3), 164-175 (2004).

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Kimberly A. Petrie, Michael Bubser, Cheryl D. Casey, M. Duff Davis, Bryan L. Roth and Ariel Y. Deutch, The Neurotensin Agonist PD14913 Increases Fos Expression in the Prefrontal Cortex of the Rat, Neuropsychopharmacology, 29, 1878-1888 (2004).

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P. Alexander Arguello and J. David Jentsch, Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat, Psychopharmacology, 177 (1-2), 141-150 (2004).

Yasuyuki Makihara, Hiroshi Yamamoto, Mai Inoue, Katsunori Tomiyama, Noriaki Koshikawa and John L. Waddington, Topographical effects of D1-like dopamine receptor agonistson orofacial movements in mice and their differential regulation via oppositional versus synergistic D1-like: D2-like interactions: cautionary observations on SK&F 82958 as an anomalous agent, Journal of Psychopharmacology, 18 (4), 484-495 (2004).

M. Soaje and R. P. Deis, Involvement of Opioid Receptor Subtypes in Both Stimulatory and Inhibitory Effects of the Opioid Peptides on Prolactin Secretion During Pregnancy, Biomedical and Life Sciences, 24 (2), 193-204 (2004).

David Feifel, Gilia Melendez and Paul D. Shilling, Reversal of Sensorimotor Gating Deficits in Brattleboro Rats by Acute Administration of Clozapine and a Neurotensin Agonist, but not Haloperidol: a Potential predictive model for novel antipsychotic effects, Neuropsychopharmacology, 29, 731-738 (2004).

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Margaret I. Davis, Jennifer Ronesi and David M. Lovinger, A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells, J. Biol. Chem., 278 (49), 48973-48980 (2003).

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Gregory Gerdeman and David M. Lovinger, CB1 Cannabinoid Receptor Inhibits Synaptic Release of Glutamate in Rat Dorsolateral Striatum, Journal of Neurophysiology, 85 (1), 468-471 (2001).

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About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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