NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine
NIMH Code: C-801
Alternative Name:
Abbreviation: L-CCG-I
Indications: group II metabotropic glutamate receptor agonist
Package Sizes:
References: M. Kawai, Y. Horikawa, T. Ishihara, K. Shimamoto and Y. Ohfune, 2-(Carboxycyclopropyl)glycines: binding, neurotoxicity and induction of intracellular free Ca2+ increase, Eur. J. Pharmacol., 211, 195-202 (1992); D. Dietrich, H. Beck, T. Kral, H. Clusmann, C. E. Elger and J. Schramm, Metabolic glutamate receptors modulate synaptic transmission in the perforant path: pharmacology and localization of two distinct receptors, Brain Res., 767, 220-227 (1997); P. Gubellini, A. Pisani, D. Cettonze, G. Bernardi and P. Calabresi, Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases, Prog. Neurobiol., 74, 271-300 (2004).
CAS: 22255-17-0
Molecular Formula: C6H9NO4
HBA: 5
HBD: 3
RotB: 3
PubChemID: 5310956
AlogP: -3.1878223
TPSA: 100.62
Activity: Excitatory Amino Acid Agonist.
Last Updated 2008-11-11 02:33 PM
Structure of C-801
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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