NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: 7-Hydroxychlorpromazine Hydrochloride
NIMH Code: C-518
Alternative Name: 2-Chloro-10-(3-dimethylaminopropyl)-7-hydroxyphenothiazine Hydrochloride
Indications: antiemetic; antipsychotic agent; dopamine antagonist
Package Sizes:
References: E. A. Nodiff, S. Ina, N. Oda, T. Hayazaki, S. Nishibe, T. Kohno, M. Hausman and A. A. Manian, Synthesis of possible metabolites of chlorpromazine. I. 7-Hydroxy derivatives of chlorpromazine, nor1-chlorpromazine and nor2-chlorpromazine, J. Heterocyclic Chem., 4, 239-245 (1967); H. I. Yamamura, A. A. Manian and S. H. Snyder, Muscarinic cholinergic receptor binding: influence of pimazide and chlorpromazine metabolites; Life Sci., 7, 685-691 (1976).
CAS: 2095-62-7
Molecular Formula: C17H20Cl2N2OS
HBA: 5
HBD: 1
RotB: 4
PubChemID: 16414
AlogP: 3.958168
TPSA: 52.01
Activity: Antiemetics; Antipsychotic Agent; Dopamine Antagonist
Last Updated 2008-11-11 02:30 PM
Structure of C-518
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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