NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (RS)-2-Chloro-5 hydroxyphenylglycine
NIMH Code: C-802
Alternative Name:
Abbreviation: CHPG
Indications: selective mGlu5 agonist
Package Sizes:
References: P. Gubellini, A. Pisani, D. Cettonze, G. Bernardi and P. Calabresi, Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases, Prog. Neurobiol., 74, 271-300 (2004); V. Neugebauer, Metabotropic glutamate receptors - important modulators of nociception and pain behavior, Pain, 98, 1-8 (2002); A. J. Doherty, M. J. Palmer, J. M. Henley, G. L. Collingridge and D. E. Jane, (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus, Neuropharmacology, 36, 265-267 (1997).
CAS:
Molecular Formula: C8H8ClNO3
HBA: 5
HBD: 3
RotB: 2
PubChemID: 3645780
AlogP: -1.1620617
TPSA: 83.55
Activity:
Comments: Available as free acid or sodium salt
Last Updated 2011-06-28 03:13 PM
Structure of C-802
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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