NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: Chrysamine G
NIMH Code: C-707
Alternative Name: 5,5'-[[1,1'-Biphenyl]-4,4'-diylbis(azo)]bis[2-hydroxybenzoic Acid]
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References: W. E. Klunk, M. L. Debnath and J. W. Pettegrew, Chrysamine-G binding to Alzheimer and control brain: autopsy study of new amyloid probe, Neurobiol. Aging, 16, 541-548 (1995); W. E. Klunk, M. L. Debnath, A. M. C. Koros and J. W. Pettegrew, Chrysamine-G, a lipophilic analogue of congo red, inhibits Abeta-induced toxicity in PC12 cells, Life Sci., 63, 1807-1814 (1998); K. Ishii, W. E. Klunk, S. Arawaka, M. L. Debnath, Y. Furiya, N. Sahara, S. Shoji, A. Tamaoka, J. W. Pettegrew and H. Mori, Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice, Neurosci. Lett., 333, 5-8 (2002).
CAS: 6472-91-9
Molecular Formula: C26H18N4O6
HBA: 10
HBD: 4
RotB: 7
PubChemID: 6506185
AlogP: 8.098
TPSA: 164.5
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Last Updated 2008-11-11 11:00 AM
Structure of C-707
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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