NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate Ethyl Ester
NIMH Code: C-803
Alternative Name:
Abbreviation: CPCCOEt
Indications: potent, selective, non-competitive mGluR1 antagonist
Package Sizes:
References: E. Hermans, S. R. Nahorski and R. A. J. Challiss, Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor, Neuropharmacology, 37, 1645-1647 (1998); R. Anwyl, Metabolic glutamate receptors: electrophysiological properties and role in plasticity, Brain Res. Rev., 29, 83-120 (1999); V. Neugebauer, Metabotropic glutamate receptors - important modulators of nociception and pain behavior, Pain, 98, 1-8 (2002); P. Gubellini, A. Pisani, D. Cettonze, G. Bernardi and P. Calabresi, Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases, Prog. Neurobiol., 74, 271-300 (2004).
CAS: 179067-99-3
Molecular Formula: C13H13NO4
HBA: 4
HBD: 1
RotB: 3
PubChemID: 6278000
AlogP: 1.0027
TPSA: 68.12
Activity:
Comments:
Last Updated 2008-11-11 02:33 PM
Structure of C-803
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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