NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (2S,1'R,2'R,3'R)-2-(2',3'-Dicarboxylcyclopropyl)glycine
NIMH Code: D-802
Alternative Name:
Abbreviation: DCG IV
Indications: anticonvulsant; selective group II mGluR agonist
Package Sizes:
References: D. Ma, Y. Cao, W. Wu and Y. Jiang, Synthesis of (2S,1'R,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine via the stereochemically controlled cyclopropanation of (S)-glyceraldehyde acetonide-derived enones, Tetrahedron, 56, 7447-7456 (2000); M. Marinozzi and R. Pellicciari, Novel enantioselective synthesis of (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV), Tetrahedron Lett., 41, 9125-9128 (2000); P. Gubellini, A. Pisani, D. Centonze, G. Bernardi and P. Calabresi, Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases, Prog. Neurobiol., 74, 271-300 (2004).
CAS: 147782-19-2
Molecular Formula: C7H9NO6
HBA: 7
HBD: 4
RotB: 4
PubChemID: 5310979
AlogP: -3.8445687
TPSA: 137.92
Activity: Anticonvulsant; Selective Group II metabotropic glutamate receptor agonist
Last Updated 2008-11-11 02:39 PM
Structure of D-802
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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