NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (±)-trans-7-Hydroxy-PIPAT Hydrochloride
NIMH Code: H-705
Alternative Name: (±)-trans-7-Hydroxy-2-[N-(n-propyl)-N-(3’-iodo-2’-propenyl)amino]tetralin Hydrochloride
Abbreviation:
Indications: selective D3 dopamine receptor agonist
Package Sizes:
References: G. D. Stanwood, R. P. Artymyshyn, M.-P. Kung, H. F. Kung, I. Lucki and P. McGonigle, Quantitative autoradiographic mapping of rat brain dopamine D3 binding with [125I]7-OH-PIPAT: evidence for the presence of D3 receptors on dopaminergic and nondopaminergic cell bodies and terminals, J. Pharmacol. Exp. Ther., 295, 1223–1231 (2000); J. N. Joyce, D2 but not D3 receptors are elevated after 9 or 11 months chronic haloperidol treatment: influence of withdrawal period, Synapse, 40, 137-144 (2001).
CAS: 148258-46-2
Molecular Formula: C16H23ClINO
HBA: 2
HBD: 1
RotB: 5
PubChemID: 6305587
AlogP: 4.7406
TPSA: 23.47
Activity: D3 dopamine receptor ligand
Comments:
Last Updated 2008-11-11 02:48 PM
Structure of H-705
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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