NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: 2-Hydroxy-N-desmethylimipramine
NIMH Code: I-504
Alternative Name: 2-Hydroxydesipramine
Indications: tricyclic antidepressive agent
Package Sizes:
References: R. T. Coutts, P. Su, G. B. Baker and M. Daneshtalab, Metabolism of imipramine in vitro by isoenzyme CYP2D6 expressed in a human cell line, and observations on metabolic stability, J. Chromatography, Biomed. Applications, 615, 265-272 (1993); T. B. Zeugin, K. Brosen and U. A. Meyer, Determination of imipramine and seven of its metabolites in human liver microsomes by a high-performance liquid chromatographic method, Anal. Biochem., 189, 99-102 (1990); J. I. Javaid, J. M. Perel and J. M. Davis, Inhibition of biogenic amines uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain, Life Sci., 24, 21-28 (1979).
CAS: 1977-15-7
Molecular Formula: C18H22N2O
HBA: 3
HBD: 2
RotB: 4
PubChemID: 121249
AlogP: 2.9330869
TPSA: 35.5
Activity: Tricyclic Antidepressive Agent
Last Updated 2008-11-11 02:48 PM
Structure of I-504
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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