NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (±)-1-Methyl-1,2,3,4-tetrahydroisoquinoline Hydrochloride
NIMH Code: I-703
Alternative Name:
Indications: Potential dopaminergic neurotoxin
Package Sizes:
References: A. Ayala, J. Parrado, J. Cano and A. Machado, Reduction of 1-methyl-1,2,3,4-tetrahydroisoquinoline level in substantia nigra of the aged rat, Brain Res., 638, 334-336 (1994); G. L. Grunewald, D. J. Sall and J. A. Monn, Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines, J. Med. Chem., 31, 433-444 (1988).
CAS: 4965-09-7
Molecular Formula: C10H14ClN
HBA: 1
HBD: 1
RotB: 0
PubChemID: 92214
AlogP: 1.9669
TPSA: 12.03
Activity: Dopamine Antagonist
Last Updated 2006-08-11 11:15 AM
Structure of I-703
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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