NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (±)-McN-5652
NIMH Code: M-704
Alternative Name: (±)-cis-1,2,3,5,6,10b-Hexahydro-6-[(4-methylthio)phenyl]pyrrolo[2,1-a]isoquinoline Perchlorate
Abbreviation: (±)-McN-5652
Indications: Serotonin transporter inhibitor
Package Sizes:
References: B. E. Maryanoff, D. F. McComsey, J. F. Gardocki, R. P. Shank, M. J. Costanzo, S. O. Nortey, C. R. Schneider and P. E. Setler, Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships, J. Med. Chem., 30, 1433-1454 (1987); R. P. Shank, J. L. Vaught, K. A. Pelley, P. E. Setler, D. F. McComsey and B. A. Maryanoff, McN-5652: a highly potent inhibitor of serotonin uptake, J. Pharmacol. Exp. Ther., 247, 1032-1038 (1988).
CAS:
Molecular Formula: C19H22ClNO4S
HBA: 2
HBD: 0
RotB: 2
PubChemID: 9994677
AlogP: 4.5867
TPSA: 28.54
Activity:
Comments:
Last Updated 2006-08-03 11:47 AM
Structure of M-704
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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