Compound Name: | (+)-McN-5652 |
NIMH Code: | M-707 |
Alternative Name: | (6S,10bR)-(+)-cis-1,2,3,5,6,10b-Hexahydro-6-[(4-methylthio)phenyl]pyrrolo[2,1-a]isoquinoline |
Abbreviation: | |
Indications: | serotonin transporter inhibitor (active enantiomer) |
Package Sizes: | |
References: | B. E. Maryanoff, D. F. McComsey, J. F. Gardocki, R. P. Shank, M. J. Costanzo, S. O. Nortey, C. R. Schneider and P. E. Setler, Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships, J. Med. Chem., 30, 1433-1454 (1987); D. F. Smith, P. N. Jensen, S. H. Poulsen, E. O. Mikkelsen, E. Elbaz and R. Glaser, Effects of pyrroloisoquinoline enantiomers ((+)-and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats, Eur. J. Pharmacol., 196, 85-92 (1991); Z. Szabo, P. F. Kao, U. Scheffel, M. Suehiro, W. B. Matthews, H. T. Ravert, J. L. Musachio, S. Marenco, S. E. Kim, G. A. Ricaurte, D. F. Wong, H. N. Wagner, Jr. and R. F. Dannals, Positron emission tomography imaging of serotonin transporters in the human brain using [11C](+)-McN5652, Synapse, 20, 37-43 (1995). |
CAS: | 103729-16-4 |
Molecular Formula: | C19H22ClNO4S |
HBA: | 2 |
HBD: | 0 |
RotB: | 2 |
PubChemID: | 146919 |
AlogP: | 4.5867 |
TPSA: | 28.54 |
Activity: | |
Comments: | |
Last Updated 2008-11-11 02:51 PM |
Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.