NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (-)-McN-5652
NIMH Code: M-708
Alternative Name: (6R,10bS)-(-)-cis-1,2,3,5,6,10b-Hexahydro-6-[(4-methylthio)phenyl]pyrrolo[2,1-a]isoquinoline Perchorate
Abbreviation: (-)-McN-5652
Indications: serotonin transporter inhibitor (inactive enantiomer)
Package Sizes:
References: B. E. Maryanoff, D. F. McComsey, J. F. Gardocki, R. P. Shank, M. J. Costanzo, S. O. Nortey, C. R. Schneider and P. E. Setler, Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships, J. Med. Chem., 30, 1433-1454 (1987); D. F. Smith, P. N. Jensen, S. H. Poulsen, E. O. Mikkelsen, E. Elbaz and R. Glaser, Effects of pyrroloisoquinoline enantiomers ((+)-and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats, Eur. J. Pharmacol., 196, 85-92 (1991); Z. Szabo, P. F. Kao, U. Scheffel, M. Suehiro, W. B. Matthews, H. T. Ravert, J. L. Musachio, S. Marenco, S. E. Kim, G. A. Ricaurte, D. F. Wong, H. N. Wagner, Jr. and R. F. Dannals, Positron emission tomography imaging of serotonin transporters in the human brain using [11C](+)-McN5652, Synapse, 20, 37-43 (1995).
CAS:
Molecular Formula: C19H22ClNO4S
HBA: 2
HBD: 0
RotB: 2
PubChemID: 6336338
AlogP: 4.5867
TPSA: 28.54
Activity:
Comments:
Last Updated 2008-11-11 02:52 PM
Structure of M-708
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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