NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: M-708
Compound Name: (-)-McN-5652
Alternative Name: (6R,10bS)-(-)-cis-1,2,3,5,6,10b-Hexahydro-6-[(4-methylthio)phenyl]pyrrolo[2,1-a]isoquinoline Perchorate
Abbreviation: (-)-McN-5652
PubChemID: 6336338
CAS: 96795-89-0
Molecular Formula: C19H22ClNO4S
Biological Activity: Serotonin transporter inhibitor (inactive enantiomer)
References: B. E. Maryanoff, D. F. McComsey, J. F. Gardocki, R. P. Shank, M. J. Costanzo, S. O. Nortey, C. R. Schneider and P. E. Setler, Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships, J. Med. Chem., 30, 1433-1454 (1987); D. F. Smith, P. N. Maryanoff, B. E.; McComsey, D. F.; Gardocki, J. F.; Shank, R. P., Costanzo, M. J.; Nortey, S. O.; Schneider, C. R.; Setler, P. E., J. Med. Chem., 1987, 30, 1433-1454. Smith, D. F.; Jensen, P. N.; Poulsen, S. H.; Mikkelsen, E. O.; Elbaz, E.; Glaser, R., Eur. J. Pharmacol., 1991, 196, 85-92.
Last Updated 2021-03-01 03:26 PM
Structure of M-708
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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