NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (+)-MK-801 Hydrogen Maleate
NIMH Code: M-107
Alternative Name: (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5,10-imine Hydrogen Maleate; Dizocilpine
Indications: selective, non-competitive NMDA glutamate receptor antagonist
Package Sizes:
References: G. S. Griesbach and A. Amsel, Immediate and long-term effects of neonatal MK-801 treatment on nonspatial learning, Proc. Natl. Acad. Sci. USA, 95, 11435-11439 (1998); E. H. F. Wong, J. A. Kemp, T. Priestley, A. R. Knight, G. N. Woodruff and L. L. Iversen, The antoconvulsant MK-801 is a potent N-methyl-D-aspartate antagonist, Proc. Natl. Acad. Sci., 83, 7104-7108 (1986).
CAS: 77086-22-7
Molecular Formula: C20H19NO4
HBA: 1
HBD: 1
RotB: 0
PubChemID: 9819165
AlogP: 3.2987
TPSA: 12.03
Last Updated 2008-11-11 02:50 PM
Structure of M-107
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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