Compound Information Page
| NIMH Code: | P-710 |
| Compound Name: | PD149163 |
| Alternative Name: | ethyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2,6-diaminohexyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3,3-dimethylbutanoyl]amino]-4-methylpentanoate |
| Abbreviation: | Lys-(psiCH2NH)-Lys-Pro-Trp-Terleu-Leu-OEt |
| PubChemID: | 11693501 |
| CAS: | 169528-11-4 |
| Molecular Formula: | C42H71N9O6 |
| Biological Activity: | Selective, brain penetrating neurotensin NTR1 receptor agonist with pro-cognitive, antipsychotic and anxiolytic effects. Neurotensin (8-13) analog. |
| References: | Wustrow, D. J.; Davis, M. D.; Akunne, H. C.; Corbin, A. E.; Wiley, J. N.; Wise, L. D.; Heffner, T. G., Bioorg. Med. Chem. Lett., 1995, 5, 997-1022. Feifel, D.; Reza, T. L.; Wustrow, D. J.; Davis, M. D., J. Pharmacol. Exp. Ther., 1999, 288, 710-713. |
| Comments: | Compound is available as the trifluoroacetate salt. The molecular weight (anhydrous) of the peptide itself is 798.07. Trifluoroacetic acid and water content may vary from lot to lot. |
| Last Updated 2021-04-09 12:22 PM | |
