NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: P-710
Compound Name: PD149163
Alternative Name: ethyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2,6-diaminohexyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3,3-dimethylbutanoyl]amino]-4-methylpentanoate
Abbreviation: Lys-(psiCH2NH)-Lys-Pro-Trp-Terleu-Leu-OEt
PubChemID: 11693501
CAS: 169528-11-4
Molecular Formula: C42H71N9O6
Biological Activity: Selective, brain penetrating neurotensin NTR1 receptor agonist with pro-cognitive, antipsychotic and anxiolytic effects. Neurotensin (8-13) analog.
References: Wustrow, D. J.; Davis, M. D.; Akunne, H. C.; Corbin, A. E.; Wiley, J. N.; Wise, L. D.; Heffner, T. G., Bioorg. Med. Chem. Lett., 1995, 5, 997-1022. Feifel, D.; Reza, T. L.; Wustrow, D. J.; Davis, M. D., J. Pharmacol. Exp. Ther., 1999, 288, 710-713.
Comments: Compound is available as the trifluoroacetate salt. The molecular weight (anhydrous) of the peptide itself is 798.07. Trifluoroacetic acid and water content may vary from lot to lot.
Last Updated 2021-04-09 12:22 PM
Structure of P-710
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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