NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: PD149163
NIMH Code: P-710
Alternative Name:
Abbreviation: Lys-(psiCH2NH)-Lys-Pro-Trp-Terleu-Leu-OEt
Indications: Neurotensin agonist; some CNS activity similar to atypical antipsychotics
Package Sizes:
References: 1) D. J. Wustrow, M. D. Davis, H. C. Akunne, A. E. Corbin, J. N. Wiley, L. D. Wise and T. G. Heffner, Reduced amide bond neurotensin 8-13 mimetics with potent in vivo activity, Bioorg. Med. Chem. Lett., 5 (9), 997-1022 (1995). 2) D. Feifel, T. L. Reza, D. J. Wustrow and M. D. Davis, Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonist, J. Pharmacol. Exp. Ther., 288 (2), 710-713 (1999).
CAS:
Molecular Formula: C42H71N9O6
HBA: 9
HBD: 8
RotB: 26
PubChemID:
AlogP: 1.5197
TPSA: 256.86
Activity:
Comments: Compound is available as the trifluoroacetate salt. The molecular weight (anhydrous) of the peptide itself is 798.07. Trifluoroacetic acid and water content may vary from lot to lot.
Last Updated 2009-04-16 01:46 PM
Structure of P-710
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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