NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (S)-(+)-N-Propylnorapomorphine Hydrochloride
NIMH Code: D-041
Alternative Name: (S)-(+)-10,11-Dihydroxy-N-(n-propyl)noraporphine Hydrochloride
Abbreviation: (S)-(+)-NPA Hydrochloride
Indications: limbic-selective dopamine antagonist
Package Sizes:
References: J. L. Neumeyer, D. Reischig, G. W. Arana, A. Campbell, R. J. Baldessarini, N. S. Kula and K. J. Watling, Aporphines. 48. Enantioselectivity of (R)-(-)- and (S)-(+)-N-n-propylnorapomorphine on dopamine receptors, J. Med. Chem., 26, 516-521 (1983); R. F. Cox, J. L. Neumeyer and B. L. Waszczak, Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons, J. Pharmacol. Exp. Ther., 247, 355-362 (1988).
CAS: 79703-31-4
Molecular Formula: C19H22ClNO2
HBA: 3
HBD: 2
RotB: 2
PubChemID: 5311191
AlogP: 3.2338736
TPSA: 43.7
Activity:
Comments:
Last Updated 2008-11-11 02:37 PM
Structure of D-041
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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