NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: S-502
Compound Name: L-(-)-threo-3-(3,4-Dihydroxyphenyl)serine
Alternative Name: (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
Abbreviation: Droxidopa; L-DOPS
PubChemID: 92974
CAS: 23651-95-8
Molecular Formula: C9H11NO5
Biological Activity:
References: Goldstein, D.S., Cardiovas. Drug Rev., 2006, 24, 189-203. Bartholini, G.; Constantinidis, J.; Puig, M.; Tissot, R.; Pletscher, A., J. Pharmacol. Exp. Ther., 1975, 193, 525-534.
Comments: Orally available prodrug of norepinephrine used in the treatment of symptomatic orthostatic hypotension due to neurogenic causes of autonomic failure and Parkinson's Disease
Last Updated 2021-04-09 03:29 PM
Structure of S-502
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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