NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: SKF-83959 Hydrobromide
NIMH Code: S-706
Alternative Name: (±)-6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-(1H)-3-benazepine Hydrobromide
Abbreviation:
Indications: dopamine D1 receptor agonist
Package Sizes:
References: D. Wirtshafter and C. V. Osborn, The atypical dopamine D1 receptor agonist SKF 83959 induces striatal Fos expression in rats, Eur. J. Pharmacol., 528, 88-94 (2005); A. R. Cools, L. Lubbers, R. V. van Oosten and G. Andringa, SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals?, Neuropharmacol., 42, 237-245 (2002); G. Andringa, B. Drukarch, J. E. Leysen, A. R. Cools and J. C. Stoof, The alleged dopamine D1 receptor agonist SKF 83959 is a dopamine D1 receptor antagonist in primate cells and interacts with other receptors, Eur. J. Pharmacol., 364, 33-41 (1999).
CAS: 80751-85-5
Molecular Formula: C18H21BrClNO2
HBA: 4
HBD: 2
RotB: 1
PubChemID: 133538
AlogP: 3.2027159
TPSA: 43.7
Activity: Dopamine D1 receptors agonist; dopamine-sensitive adenylyl cyclase inhibitor
Comments:
Last Updated 2008-11-11 03:01 PM
Structure of S-706
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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