NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: SR 141716
NIMH Code: S-705
Alternative Name: N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Indications: CB1 cannabinoid receptor antagonist
Package Sizes:
References: P. M. Beardsley, M. E. Dance, R. L. Balster and P. Munzar, Evaluation of the reinforcing effects of the cannabinoid CB1 receptor antagoist, SR141716, in rhesus monkeys, Eur. J. Pharmacol., 435, 209-216 (2002); T. J. DeVries, Y. Shaham, J. R. Homberg, H. Crombag, K. Schurman, J. Dieben, L. J. M. J. Vanderschuren and A. N. M. Schoffelmeer, A cannabinoid mechanism in relapse to cocaine seeking, Nature Med., 7, 1151-1154 (2001); M. Rinaldi-Carmona, F. Barth, M. Heaulme, D. Shire, B. Calandra, C. Congy, S. Martinez, J. Maruani, G. Neliat, D. Caput, P. Ferrara, P. Soubrie, J. C. Breliere and G. L. Fur, SR141716A, a potent and selective antagonist of the brain cannabinoid receptor, FEBS Lett., 350, 240-244 (1994).
CAS: 158681-13-1
Molecular Formula: C22H21CI3N4O
HBA: 6
HBD: 1
RotB: 4
PubChemID: 104850
AlogP: 5.3583
TPSA: 50.16
Activity: CB1 cannabinoid receptor antagonist
Comments: The compound supplied by NIMH is the free base. The "A" was dropped from the name on 12/09/2003.
Last Updated 2008-11-11 03:01 PM
Structure of S-705
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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