NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: W-7 [N-(6-Aminocyclohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride]
NIMH Code: W-502
Alternative Name:
Abbreviation: W-7
Indications: calmodulin antagonist
Package Sizes:
References: H. Hidaka, M. Asano and T. Tanaka, Structure-activity relationship of calmodulin antagonists: naphthalenesulfonamide derivatives, Mol. Pharmacol., 20, 571-578 (1981); H. Hidaka, Y. Sasaki, T. Tanaka, T. Endo, S. Ohno, Y. Fujii and T. Nagata, N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonists, inhibits cell proliferation, Proc. Natl. Acad. Sci. USA, 78, 4354-4357 (1981); H. Hidaka, M. Asano, S. Iwadare, I. Matsumoto, T. Totsuka and N. Aoki, A novel vascular relaxing agent, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide which affects vascular smooth muscle actomyosin, J. Pharmacol. Exp. Ther., 207, 8-15 (1978).
CAS: 65595-90-6
Molecular Formula: C16H22Cl2N2O2S
HBA: 5
HBD: 2
RotB: 7
PubChemID: 5681
AlogP: 2.0569296
TPSA: 80.57
Activity: Vasodilator Agent
Comments:
Last Updated 2008-11-11 03:06 PM
Structure of W-502
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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