NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: SR 48692
NIMH Code: S-802
Alternative Name: 2-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino]admantane-2-carboxylic Acid
Indications: non-peptide neurotensin receptor antagonist
Package Sizes:
References: T. W. Moody, J. Chiles, M. Casibang, E. Moody, D. Chan and T. P. Davis, SR48692 is a neurotension receptor antagonists which inhibits the growth of small cell lung cancer cells, Peptides, 22, 109-115 (2001); W. Rostene, M. Azzi, C. Betancur, D. Pelaprat, D. Gully, R. Spanagel and A. Berod, Neurotensin antagonists and dopaminergic function, Biol. Psychiatry, 42, Supplement 1, 287S-288S (1997); D. Gully, M. Canton, R. Boigegrain, F. Jeanjean, J.-C. Molimard, M. Poncelet, C. Gueudet, M. Heaulme, R. Leyris, A. Brouard, D. Pelaprat, C. Labbe-Jullie, J. Mazella, P. Soubrie, J.-P. Maffrand, W. Rostene, P. Kitabgi and G. Le Fur, Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor, Proc. Natl. Acad. Sci. USA, 90, 65-69 (1993); J. P. Maffrand, D. Gully, R. Boigegrain, P. Soubrie, P. Kitabgi, W. Rostene and G. Le Fur, Neurotensin receptor agonists and antagonists, Drugs Fut., 18, 1137-1141 (1993).
CAS: 146362-70-1
Molecular Formula: C32H31ClN4O5
HBA: 8
HBD: 2
RotB: 6
PubChemID: 119192
AlogP: 1.3149302
TPSA: 115.57
Activity: Neurotensin receptor antagonist
Last Updated 2008-11-11 03:01 PM
Structure of S-802
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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