NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: S-901
Compound Name: Spiperone
Alternative Name: (±)-8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Abbreviation: 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
PubChemID: 5265
CAS: 749-02-0
Molecular Formula: C23H26FN3O2
Biological Activity: Serotonin 5-HT1A, 5-HT2A, 5-HT7, and dopamine D2 antagonist, a typical antipsychotic used to treat schizophrenia
References: Zheng, L.T.; Hwang, J.; Ock, J.; Lee, M.G.; Lee, W.H.; Suk, K., J. Neurochem., 2008, 107, 1225–1235. Liang, L.; Macdonald, K.D.; Schwiebert, E.M.; Zeitlin, P.L.; Guggino, W.B., Am J Physiol Cell Physiol., 2008, 296, C131–141.
Last Updated 2021-04-12 09:21 AM
Structure of S-901
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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