NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: Spiperone
NIMH Code: S-901
Alternative Name: (±)-8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Abbreviation: 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Indications: Serotonin 5-HT1A, 5-HT2A, 5-HT7, and dopamine D2 antagonist, a typical antipsychotic used to treat schizophrenia
Package Sizes:
References: Zheng, L.T.; Hwang, J.; Ock, J.; Lee, M.G.; Lee, W.H.; Suk, K., J. Neurochem., 2008, 107, 1225–1235. Liang, L.; Macdonald, K.D.; Schwiebert, E.M.; Zeitlin, P.L.; Guggino, W.B., Am J Physiol Cell Physiol., 2008, 296, C131–141.
CAS: 749-02-0
Molecular Formula: C23H26FN3O2
HBA: 5
HBD: 1
RotB: 6
PubChemID: 5265
AlogP: 3.0221
TPSA: 52.65
Activity: Antipsychotic Agent; Dopamine Antagonist
Comments:
Last Updated 2021-04-12 09:21 AM
Structure of S-901
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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