NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: SR 142948
NIMH Code: S-902
Alternative Name: 2-[[5-(2,6-Dimethoxyphenyl)-1-(4-(3-N’,N’-dimethylaminopropyl)-N-methylcarbamoyl)-2-isopropylphenyl)-1H-pyrazole-3-carbonyl]amino]adamantane-2-carboxylic Acid Hydrochloride
Abbreviation: SR 142948
Indications: Potent neurotensin receptor antagonist
Package Sizes:
References: D. Gully, B. Labeeuw, R. Boigegrain, F. Oury-Donat, A. Bachy, M. Poncelet, R. Steinberg, M. F. Suaud-Chagny, V. Santucci, N. Vita, F. Pecceu, C. Labbe-Jullie, P. Kitabgi, P. Soubrie, G. Le Fur and J. P. Maffraud, Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist, J. Pharmacol. Exp. Ther., 280, 802-812 (1997); R. Boigegrain, J. C. Molimard, D. Gully, B. Labeeuw, F. Jeanjean, S. A. Sanofi, 1-Phenylpyrazole-3-carboxamides acting on neurotensin receptors, International Patent No. WO 9632382 (October 17, 1996).
CAS: 184162-64-9 (base)
Molecular Formula: C39H52ClN5O6
HBA: 8
HBD: 2
RotB: 12
PubChemID: 5311451
AlogP: -2.3102815
TPSA: 126.23
Activity:
Comments:
Last Updated 2014-03-07 05:26 PM
Structure of S-902
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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