NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: SIB-1553A
NIMH Code: S-903
Alternative Name: (±)-4-[2-(1-Methylpyrrolidin-2-yl)ethylsulfanyl]phenol Hydrochloride, 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
Indications: nicotinic acetylcholine receptor agonist; possible cognitive enhancer
Package Sizes:
References: J. M. Vernier, H. El-Abdellaoui, H. Holsenback, N. D. P. Cosford, L. Bleicher, G. Barker, B. Bontempi, L. Chavez-Noriega, F. Menzaghi, T. S. Rao, R. Reid, A. I. Sacaan, C. Suto, M. Washburn, G. K. Lloyd and I. A. McDonald, 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): A novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors, J. Med. Chem., 42, 1684-1686 (1999).
CAS: 191611-89-9
Molecular Formula: C13H20ClNOS
HBA: 3
HBD: 1
RotB: 4
PubChemID: 9881989
AlogP: 2.294513
TPSA: 48.77
Last Updated 2015-01-21 09:34 AM
Structure of S-903
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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