NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: SKF-83822 Hydrobromide
NIMH Code: S-904
Alternative Name: (±)-3-Allyl-6-chloro-7,8-dihydroxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-(1H)-3-benazepine Hydrobromide
Indications: Agonist at dopamine D1-like receptors that stimulate adenylyl cyclase
Package Sizes:
References: J. Weinstock, Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds, US Patent 4,160,765 (July 10, 1979); F. R. Pfeiffer, J. W. Wilson, J. Weinstock, G. Y. Kuo, P. A. Chambers, K. G. Holden, R. A. Hahn, J. R. Wardell, Jr., A. J. Tobia, P. E. Setler and H. M. Sarau, Dopaminergic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, J. Med. Chem., 25, 352-358 (1982); G. J. O'Sullivan, B. L. Roth, A. Kinsella and J. L. Waddington, SK&F 83822 distinquishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography, Eur. J. Pharmacol., 486, 273-280 (2004).
Molecular Formula: C20H23BrClNO2
HBA: 4
HBD: 2
RotB: 3
PubChemID: 10020353
AlogP: 4.4544706
TPSA: 43.7
Last Updated 2005-05-25 05:35 PM
Structure of S-904
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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