NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: WAY 405
NIMH Code: W-901
Alternative Name: (R)-N-[2-Methyl-(4-indolyl-1-piperazinyl)ethyl]-N-(2-pyridyl)cyclohexanecarboxamide Dihydrochloride
Indications: Selective 5-HT1A receptor antagonist
Package Sizes:
References: C. I. Brightwell and G. M. Kelly, Piperazine derivatives as 5HT1A antagonists, PCT International Patent WO 95/33743 (December 14, 1995); Y. Minabe, L. Schechter, K. Hashimoto, Y. Shirayama and C. R. Ashby, Jr., Acute and chromic administration of the selective 5-HT1A receptor antagonist WAY-405 significantly alters the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study, Synapse, 50, 181-190 (2003); R. Villalobos-Molina, M. Orozco-Mendez, J. J. Lopez-Guerrero and I. A. Gallardo-Ortiz, WAY 405, a new silent 5-HT1A receptor antagonistr with low affinity for vascular alpha1-adrenoceptors, Autonomic Autacoid Pharmacol., 25, 185-189 (2005).
Molecular Formula: C27H37Cl2N5O
HBA: 4
HBD: 1
RotB: 6
AlogP: 4.8532
TPSA: 55.47
Last Updated 2006-04-18 12:34 PM
Structure of W-901
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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