NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: T-907
Compound Name: Tolcapone
Alternative Name: (3,4-Dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone; 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
Abbreviation: Ro-40-7592
PubChemID: 4659569
CAS: 134308-13-7
Molecular Formula: C14H11NO5
Biological Activity: Nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT) used to treat Parkinson's disease
References: Truong, D.D., Clin. Interv. Aging, 2009, 4, 109-113. Antonini, A.; Abbruzzese, G.; Barone, P.; Bonuccelli, U.; Lopiano, L.; Onofrj, M.; Zappia, M., Neuropsychiatr. Dis. Treat., 2008, 4, 1-9.
Last Updated 2021-04-12 12:04 PM
Structure of T-907
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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