NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: H-907
Compound Name: (Z)-4-Hydroxytamoxifen
Alternative Name: {(Z)-1-[4-(2-N,N-Dimethylaminoethoxy)phenyl]- 1-(4-hydroxyphenyl)-2-phenylbut-1-ene}
Abbreviation: 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
PubChemID: 449459
CAS: 68392-35-8
Molecular Formula: C26H29NO2
Biological Activity: Estrogen receptor antagonist
References: S. Gauthier, J. Mailhot and F. Labrie, J. Org. Chem. 1996, 61, 3890-3893. Guan, J.; Zhou, W.; Hafner, M.; Blake, R.A.; Chalouni, C.; Chen, I.P.; De Bruyn, T.; Giltnane, J.M.; Hartman, S.J.; Heidersbach, A.; Houtman, R.; Ingalla, E.; Kategaya, L.; Kleinheinz, T.; Li, J.; Martin, S.E.; Modrusan, Z.; Nannini, M.; Oeh, J.; Ubhayakar, S.; Wang, X.; Wertz, I.E.; Young, A.; Yu, M.; Sampath, D.; Hager, J.H.; Friedman, L.S.; Daemen, A.; Metcalfe, C., Cell, 2019, 178, 949-963.e18.
Last Updated 2021-02-24 08:20 AM
Structure of H-907
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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