NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: H-908
Compound Name: {4-[4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid
Alternative Name: 2-[4-[[4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-propan-2-ylphenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Abbreviation: NH-3
PubChemID: 10027822
CAS: 447415-26-1
Molecular Formula: C28H27NO6
Biological Activity: beta-subtype selective thyroid hormone receptor antagonist
References: Chiellini, G.; Nguyen, N. H.; Yoshihara, H. A.; Scanlan, T. S. Bioorg. Med. Chem. 2000, 10, 2607-2611. Joharapurkar, A.A.; Dhote, V.V.; Jain, M.R., J. Med. Chem., 2012, 55, 5649-5675.
Last Updated 2021-02-24 08:23 AM
Structure of H-908
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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