NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: P-903
Compound Name: 3-{2-[4-(6-Fluorobenzo[d]isoxazol-3-yl)-1-piperidyl]ethyl}-7-hydoxy-4-methyl-1,5-diazabicyclo[4.4.0]deca-3,5-dien-2-one
Alternative Name: 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
Abbreviation: Paliperidone; 9-hydroxy risperidone
PubChemID: 115237
CAS: 144598-75-4
Molecular Formula: C23H27FN4O3
Biological Activity: Resperidone metabolite; atypical antipsychotic used to treat schizophrenia and schizoaffective disorder
References: Janssen, C. G. M.; Knaeps, A. G.; Kennis, L. E. J.; Vandenberk, J. U.S. Patent 5 158 952, 1992. Leucht, S.; Cipriani, A.; Spineli, L.; Mavridis, D.; Orey, D.; Richter, F.; Samara, M.; Barbui, C.; Engel, R.R.; Geddes, J.R.; Kissling, W.; Stapf, M.P.; Lässig, B.; Salanti, G.; Davis, J.M., Lancet, 2013, 382, 951-962.
Last Updated 2021-04-09 01:13 PM
Structure of P-903
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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