NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: 3-{2-[4-(6-Fluorobenzo[d]isoxazol-3-yl)-1-piperidyl]ethyl}-7-hydoxy-4-methyl-1,5-diazabicyclo[4.4.0]deca-3,5-dien-2-one
NIMH Code: P-903
Alternative Name: 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
Abbreviation: Paliperidone; 9-hydroxy risperidone
Indications: Resperidone metabolite; atypical antipsychotic used to treat schizophrenia and schizoaffective disorder
Package Sizes:
References: Janssen, C. G. M.; Knaeps, A. G.; Kennis, L. E. J.; Vandenberk, J. U.S. Patent 5 158 952, 1992. Leucht, S.; Cipriani, A.; Spineli, L.; Mavridis, D.; Orey, D.; Richter, F.; Samara, M.; Barbui, C.; Engel, R.R.; Geddes, J.R.; Kissling, W.; Stapf, M.P.; Lässig, B.; Salanti, G.; Davis, J.M., Lancet, 2013, 382, 951-962.
CAS: 144598-75-4
Molecular Formula: C23H27FN4O3
HBA: 7
HBD: 1
RotB: 4
PubChemID: 115237
AlogP: 2.0166
TPSA: 82.17
Activity: Atypical antipsychotic used to treat schizophrenia and schizoaffective disorder
Comments:
Last Updated 2021-04-09 01:13 PM
Structure of P-903
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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