NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: P-906
Compound Name: (+)-(4aR,10bR)-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol hydrochloride
Alternative Name: (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol hydrochloride
Abbreviation: Naxagolide hydrochloride; (+)-PHNO hydrochloride
PubChemID: 57532
CAS: 99705-65-4
Molecular Formula: C15H22ClNO2
Biological Activity: Dopamine D2/3 receptor agonist; PET ligand reference standard.
References: Jones, J. H.; Anderson, P. S.; Baldwin, J. J.; Clineschmidt, B. V.; McClure, D. E.; Lundell, G. F.; Randall, W. C.; Martin, G. E.; Williams, M.; Hirshfield, J. M.; Smith, G.; Lumma, P. K. J. Med. Chem. 1984, 27, 1607-1613. Martin, G. E.; Williams, M.; Pettibone, D. J.; Yarbrough, G. G.; Clineschmidt, B. V.; Jones, J. H. J. Pharmacol. Exp. Ther. 1984, 230, 569-576. 3. Martin, G. E.; Williams, M.; Pettibone, D. J.; Zrada, M. M.; Lotti, V. J.; Taylor, D. A.; Jones, J. H. J. Pharmacol. Exp. Ther. 1985, 233, 395-401.
Comments:
Last Updated 2021-04-09 01:26 PM
Structure of P-906
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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