NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (-)-(2S,4R)-1-{(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl}-4-hydroxy-N,N-dimethyl-2-pyrrolidine-carboxamide
NIMH Code: N-905
Alternative Name: (2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide
Abbreviation: Nelivaptan
Indications: Orally-active non-peptide vasopressin V1b receptor antagonist
Package Sizes:
References: Serradeil-Le Gal, C.; Wagnon, J.; Simiand, J.; Griebel, G.; Lacour, C.; Guillon, G.; Barberis, C.; Brossard, G.; SoubriƩ, P.; Nisato, D.; Pascal, M.; Pruss, R.; Scatton, B.; Maffrand, J. P.; Le Fur, G. J. Pharmacol. Exp. Ther. 2002, 300, 1122-1130. Serradeil-Le Gal, C.; Wagnon, J.; Tonnerre, B.; Roux, R.; Garcia, G.; Griebel, G.; Aulombard, A. CNS Drug Rev. 2005, 11, 53-68.
CAS: 439687-69-1
Molecular Formula: C30H32ClN3O8S
HBA: 9
HBD: 1
RotB: 8
PubChemID: 9895468
AlogP:
TPSA: 134
Activity: Orally-active non-peptide vasopressin V1b receptor antagonist
Comments:
Last Updated 2021-03-15 07:46 AM
Structure of N-905
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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