NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: B-917
Compound Name: Buprenorphine hydrochloride
Alternative Name: (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol hydrochloride
PubChemID: 3033050
CAS: 53152-21-9
Molecular Formula: C29H42ClNO4
Biological Activity: High affinity partial mu-opioid receptor agonist, used to treat opioid use disorder, acute pain, and chronic pain
References: Cowan, A.; Lewis, J. W.; Macfarlane, I. R. Br. J. Pharm. 1977, 60, 537-545. White, L.D.; Hodge, A., Vlok, R.; Hurtado, G.; Eastern, K., Melhuish, T.M., Br. J. Anaesth., 2018, 120, 668-678.
Comments: DEA schedule III controlled substance
Last Updated 2021-02-17 11:23 AM
Structure of B-917
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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