NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: C-927
Compound Name: (+)-6-((R)-2-{2-[4-(4-Chlorophenoxy)piperidin-1-yl]ethyl}pyrrolidine-1-sulphonyl)-1H-indole hydrochloride
Alternative Name: 6-[(2R)-2-[2-[4-(4-chlorophenoxy)piperidin-1-yl]ethyl]pyrrolidin-1-yl]sulfonyl-1H-indole hydrochloride
Abbreviation: SB-656104-A
PubChemID: 10028436
CAS: 527750-76-1
Molecular Formula: C25H31Cl2N3O3S
Biological Activity: High-affinity, selective 5-HT7 antagonist
References: Forbes, I. T.; Douglas, S.; Gribble, A. D.; Ife, R. J.; Lightfoot, A. P.; Garner, A. E.; Riley, G. J.; Jeffrey, P.; Stevens, A. J.; Stean, T. O.; Thomas, D. R. Bioorg. Med. Chem. Lett. 2002, 12, 3341-3344. Thomas, D. R.; Melotto, S.; Massagrande, M.; Gribble, A. D.; Jeffrey, P.; Stevens, A. J.; Deeks, N. J.; Eddershaw, P. J.; Fenwick, S. H.; Riley, G.; Stean, T.; Scott, C. M.; Hill, M. J.; Middlemiss, D. N.; Hagan, J. J.; Price, G. W.; Forbes, I. T. Br. J. Pharmacol. 2003, 139, 705-714.
Comments: PubChem ID is for the base
Last Updated 2021-02-18 03:45 PM
Structure of C-927
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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