NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: 9-Isopropyl-N-[3-(trifluoromethyl)benzyl]-9H-purin-6-amine
NIMH Code: L-905
Alternative Name: 9-propan-2-yl-N-[[3-(trifluoromethyl)phenyl]methyl]purin-6-amine
Abbreviation: Longdaysin
Indications: CK1, ERK2 and CDK7 kinases inhibitor that results in a lengthening of circadian periods
Package Sizes:
References: Kolarski, D.; Sugiyama, A.; Breton, G.; Rakers, C.; Ono, D.; Schulte, A.; Tama, F.; Itami, K.; Szymanski, W.; Hirota, T.; Feringa, B.L., J. Am. Chem. Soc., 2019, 141, 15784-15791. Lee, J.W.; Hirota, T.; Ono, D.; Honma, S.; Honma, K.; Park, K.; Kay, S.A., J. Med. Chem., 2019, 62, 1989-1998.
CAS: 1353867-91-0
Molecular Formula: C16H16F3N5
HBA: 7
HBD: 1
RotB: 4
PubChemID: 49830252
AlogP:
TPSA: 55.6
Activity: CK1, ERK2 and CDK7 kinases inhibitor
Comments:
Last Updated 2021-03-01 08:59 AM
Structure of L-905
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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