NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: B-918
Compound Name: 1,3-Bis(8-acetyleno-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine-3-carboxy)propyl diester
Alternative Name: XLi-093
Abbreviation: Bis[8-ethynyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid] 1,3-propanediyl ester
PubChemID: 131701296
CAS: 646066-59-3
Molecular Formula: C33H26N6O6
Biological Activity: Selective alpha5 GABA-A receptor antagonist/negative allosteric modulator
References: Li, X.; Cao, H.; Zhang, C.; Furtmüeller, R.; Fuchs, K.; Huck, S.; Sieghart, W.; Deschamps, J.; Cook, J. M., J. Med. Chem. 2003, 46, 5567-5570. Savic, M.; Milinkovic, M.; Rallapalli, S.; Clayton, T. Sr.; Joksimovic, S.; Van Linn, M.; Cook, J., Neuropsychopharmacology 2009, 12, 1179-1193. Xu, N.Z.; Ernst, M.; Treven, M.; Cerne, R.; Wakulchik, M.; Li, X.; Jones, T.M.; Gleason, S.D.; Morrow, D.; Schkeryantz, J.M.; Rahman, M.T.; Li, G.; Poe, M.M.; Cook, J.M.; Witkin, J.M., Psychopharmacology, 2018, 235, 1151-1161.
Comments: Note the structure in PubChem may not be correct
Last Updated 2021-02-17 11:37 AM
Structure of B-918
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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