NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: (2S)-2-Amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid trifluoroacetate New!
NIMH Code: C-930
Alternative Name: L-4-Chlorokynurenine trifluoroacetate
Abbreviation: 4-Cl-KYN TFA
Indications: Prodrug of the glycine binding site NMDA receptor antagonist 7-chlorokynurenine.
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References: Zanos P, Piantadosi SC, Wu HQ, Pribut HJ, Dell MJ, Can A, Snodgrass HR, Zarate CA Jr, Schwarcz R, Gould TD. The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition. J Pharmacol Exp Ther. 2015 Oct;355(1):76-85. Salituro, F. G.; Tomlinson, R. C.; Baron, B. M.; Palfreyman, M. G.; McDonald, I. A.; Schmidt, W.; Wu, H. Q.; Guidetti, P.; Schwarcz, R. J. Med. Chem. 1994, 37, 334-336. Salituro, F. G.; McDonald, I. A. J. Org. Chem. 1988, 53, 6138-6139.
CAS: 75802-84-5
Molecular Formula: C12H12ClF3N2O5
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Last Updated 2016-07-18 03:13 PM
Structure of C-930
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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