NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: C-930
Compound Name: (2S)-2-Amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid (4-Cl-KYN) trifluoroacetate
Alternative Name: L-4-Chlorokynurenine trifluoroacetate; 2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid trifluoroacetate
Abbreviation: 4-Cl-KYN TFA
PubChemID: 173480
CAS: 75802-84-5
Molecular Formula: C12H12ClF3N2O5
Biological Activity: Prodrug of the glycine binding site NMDA receptor antagonist 7-chlorokynurenine
References: Zanos, P.; Piantadosi, S.C.; Wu, H.Q.; Pribut, H.J.; Dell, M.J.; Can, A. Snodgrass, H.R.; Zarate, C.A.; Schwarcz, R.; Gould, T.D., J Pharmacol Exp Ther., 2015, 355, 76-85. Salituro, F. G.; Tomlinson, R. C.; Baron, B. M.; Palfreyman, M. G.; McDonald, I. A.; Schmidt, W.; Wu, H. Q.; Guidetti, P.; Schwarcz, R. J. Med. Chem. 1994, 37, 334-336.
Comments: CAS Number and PubChem ID are for the base
Last Updated 2021-06-02 04:40 PM
Structure of C-930
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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