NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

Compound Name: Deschloroclozapine (DCZ) Dihydrochloride
NIMH Code: D-925
Alternative Name: DREADD DCZ Dihydrochloride
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Indications: DREADD ligand
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References: 1) Nagai Y, Miyakawa N, Takuwa H, Hori Y, Oyama K, Ji B, Takahashi M, Huang XP, Slocum ST, DiBerto JF, Xiong Y. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nature Publishing Group; 2020 Jul 6. 2) Phillips ST, de Paulis T, Baron BM, et al. Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. J Med Chem. 1994;37(17):2686-2696. 3) Upright and Baxter (2019) bioRxiv : https://doi.org/10.1101/864140.
CAS: 1977-07-7 (base)
Molecular Formula: C18H22Cl2N4
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Comments: Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator. Water soluble.
Last Updated 2020-09-02 02:28 PM
Structure of D-925
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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