Compound Name: | Deschloroclozapine (DCZ) Dihydrochloride |
NIMH Code: | D-925 |
Alternative Name: | DREADD DCZ Dihydrochloride |
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Indications: | DREADD ligand |
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References: | 1) Nagai Y, Miyakawa N, Takuwa H, Hori Y, Oyama K, Ji B, Takahashi M, Huang XP, Slocum ST, DiBerto JF, Xiong Y. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nature Publishing Group; 2020 Jul 6. 2) Phillips ST, de Paulis T, Baron BM, et al. Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. J Med Chem. 1994;37(17):2686-2696. 3) Upright and Baxter (2019) bioRxiv : https://doi.org/10.1101/864140. |
CAS: | 1977-07-7 (base) |
Molecular Formula: | C18H22Cl2N4 |
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Comments: | Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator. Water soluble. |
Last Updated 2020-09-02 02:28 PM |
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