NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: J-902
Compound Name: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine (JHU37160) Dihydrochloride New!
Alternative Name: JHU37160 Dihydrochloride
Abbreviation: J60 2HCl
Molecular Formula: C19H22Cl3FN4
Biological Activity: DREADD agonist with high affinity and potency for CNS applications.
References: 1. DREADD Actuators. PCT application 1,916,892. 2. Bonaventura J, Eldridge MAG, Hu F, et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019;10(1):4627. 3. Goutaudier R, Coizet V, Carcenac C, Carnicella S. DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands. eNeuro. 2019;6(5):ENEURO.0171-19.2019.
Comments: Water soluble
Last Updated 2021-05-28 11:38 AM
Structure of J-902
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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