NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: J-905
Compound Name: JHU37107 dihydrochloride New!
Alternative Name: 8-Chloro-11-(4-ethylpiperazin-1-yl)-2-fluoro-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
Molecular Formula: C19H22Cl3FN4
Biological Activity: DREADD agonist with high affinity and potency for CNS applications.
References: DREADD Actuators. PCT application 1,916,892. Bonaventura, J.; Eldridge, M. A. G.; Hu, F.; et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat. Commun. 2019, 10, 4627.
Last Updated 2024-05-01 05:00 PM
Structure of J-905
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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