NIMH Chemical Synthesis and Drug Supply Program

Compound Information Page

NIMH Code: S-914
Compound Name: SAFit2 Hydrochloride New!
Alternative Name: (1R)-3-(3,4-Dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate Hydrochloride
Abbreviation: SAFit2 • HCl
CAS: 1643125-33-0 (base)
Molecular Formula: C46H63ClN2O10
Biological Activity: SAFit2 is a selective antagonist for the FK506-binding protein 51 (FKBP51), which has been shown to enhance stress hormone regulation and have anxiolytic and antidepressant-like effects.
References: Gaali, S., et al., Rapid, structure-based exploration of pipecolic acid amides as novel selective antagonists of the FK506-binding protein 51. J. Med. Chem. 2016, 59, 2410-2422.
Last Updated 2024-05-10 06:29 PM
Structure of S-914
About The Program

Since 1959, the NIMH Chemical Synthesis and Drug Supply Program has synthesized and distributed novel research chemicals, psychoactive drugs, and compounds that are unavailable from commercial sources to the scientific community working on research relevant to mental health.

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