| NIMH Code: |
S-914 |
| Compound Name: |
SAFit2 Hydrochloride
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| Alternative Name: |
(1R)-3-(3,4-Dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate Hydrochloride |
| Abbreviation: |
SAFit2 • HCl |
| PubChemID: |
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| CAS: |
1643125-33-0 (base) |
| Molecular Formula: |
C46H63ClN2O10 |
| Biological Activity: |
SAFit2 is a selective antagonist for the FK506-binding protein 51 (FKBP51), which has been shown to enhance stress hormone regulation and have anxiolytic and antidepressant-like effects. |
| References: |
Gaali, S., et al., Rapid, structure-based exploration of pipecolic acid amides as novel selective antagonists of the FK506-binding protein 51. J. Med. Chem. 2016, 59, 2410-2422. |
| Comments: |
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| Last Updated 2024-05-10 06:29 PM |
